CRCGN008_HEPG2_24H:D04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phosphonium sulfate 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

114 genes differentially expressed following the CRCGN008_HEPG2_24H:D04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 5.1647
EPHB2 EPH receptor B2 5.05428
UBQLN2 ubiquilin 2 4.9654
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.94945
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.78277
E2F2 E2F transcription factor 2 4.72025
HLA-DMA major histocompatibility complex, class II, DM alpha 4.5826
BACE2 beta-site APP-cleaving enzyme 2 4.3374
MYLK myosin light chain kinase 4.14115
HLA-DRA major histocompatibility complex, class II, DR alpha 4.13908
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.0733
CBR3 carbonyl reductase 3 3.90465
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 3.3524
BAD BCL2-associated agonist of cell death 3.2346
GPATCH8 G patch domain containing 8 3.2007
MAP7 microtubule-associated protein 7 3.16722
TIAM1 T-cell lymphoma invasion and metastasis 1 3.14083
PRR15L proline rich 15-like 2.9004
LCN2 lipocalin 2 2.8623
CCL2 chemokine (C-C motif) ligand 2 2.82915
JADE2 jade family PHD finger 2 2.76992
NANOS2 nanos homolog 2 (Drosophila) 2.7267
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.69476
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.66655
USP6NL USP6 N-terminal like 2.652
COX7B cytochrome c oxidase subunit VIIb 2.56595
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.53538
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.53265
CRTAP cartilage associated protein 2.51475
TBP TATA box binding protein 2.48535
STXBP2 syntaxin binding protein 2 2.473
TBXA2R thromboxane A2 receptor 2.46584
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.45765
BGLAP bone gamma-carboxyglutamate (gla) protein 2.4413
IL13 interleukin 13 2.3935
CRYBB3 crystallin, beta B3 2.38585
CRIPTO3 cripto, EGF-CFC family member 3 2.352
PSKH1 protein serine kinase H1 2.3302
CD200R1 CD200 receptor 1 2.2975
TULP1 tubby like protein 1 2.29185
CCKAR cholecystokinin A receptor 2.2725
LRP5 low density lipoprotein receptor-related protein 5 2.27165
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) 2.27085
GTF2H5 general transcription factor IIH, polypeptide 5 2.2641
TNIP1 TNFAIP3 interacting protein 1 2.25685
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 2.2563
ALOX12 arachidonate 12-lipoxygenase 2.2492
COL2A1 collagen, type II, alpha 1 2.22948
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.2276
CDX2 caudal type homeobox 2 2.21415
FAM120C family with sequence similarity 120C 2.20215
CD40 CD40 molecule, TNF receptor superfamily member 5 2.19278
CRLF1 cytokine receptor-like factor 1 2.1864
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.1711
EPHA3 EPH receptor A3 2.16203
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.1617
NLGN3 neuroligin 3 2.1553
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 2.1528
FANCF Fanconi anemia, complementation group F 2.14005
CD70 CD70 molecule 2.13915
CYCS cytochrome c, somatic 2.13735
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.13555
ANGPT4 angiopoietin 4 2.12775
PRDX4 peroxiredoxin 4 2.1212
AAMP angio-associated, migratory cell protein 2.11445
SOD3 superoxide dismutase 3, extracellular 2.10105
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 2.1008
ZNF552 zinc finger protein 552 2.1001
ITK IL2-inducible T-cell kinase 2.0852
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.08395
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.05805
ACR acrosin 2.0573
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.04945
ZSCAN2 zinc finger and SCAN domain containing 2 2.03925
APOL5 apolipoprotein L, 5 2.0325
VWA7 von Willebrand factor A domain containing 7 2.02915
GRK3 G protein-coupled receptor kinase 3 2.02822
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.02353
CSF1 colony stimulating factor 1 (macrophage) 2.01714
HSPA1A heat shock 70kDa protein 1A 2.0157
TPSG1 tryptase gamma 1 2.0134
ITGA9 integrin, alpha 9 2.00815

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.71605
CDC20 cell division cycle 20 -5.33725
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.2457
ADI1 acireductone dioxygenase 1 -5.14305
LDHD lactate dehydrogenase D -5.0891
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0516
SLC35F2 solute carrier family 35, member F2 -5.0307
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.8989
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.59615
RGS2 regulator of G-protein signaling 2 -3.7962
CCNB1 cyclin B1 -3.70555
GDF15 growth differentiation factor 15 -3.5107
PRPF4 pre-mRNA processing factor 4 -3.496
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.4892
RNF167 ring finger protein 167 -3.4875
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.89625
GRM3 glutamate receptor, metabotropic 3 -2.68975
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.62727
CHIC2 cysteine-rich hydrophobic domain 2 -2.56415
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.36835
CDC25B cell division cycle 25B -2.35105
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.2713
FBXL6 F-box and leucine-rich repeat protein 6 -2.25405
SETD5 SET domain containing 5 -2.228
GLOD4 glyoxalase domain containing 4 -2.17215
NLRP4 NLR family, pyrin domain containing 4 -2.15715
FAM32A family with sequence similarity 32, member A -2.15505
CCNH cyclin H -2.15415
MEIS2 Meis homeobox 2 -2.13005
ANPEP alanyl (membrane) aminopeptidase -2.0875
PROM1 prominin 1 -2.07825
PRPF8 pre-mRNA processing factor 8 -2.06795