CRCGN008_HEPG2_24H:D05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phosphonium sulfate 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN008_HEPG2_24H:D05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 5.5534
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.2844
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.0
C2CD2 C2 calcium-dependent domain containing 2 4.8093
STK10 serine/threonine kinase 10 4.40957
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.1035
PEX11A peroxisomal biogenesis factor 11 alpha 4.06693
EGF epidermal growth factor 3.89
CXCL2 chemokine (C-X-C motif) ligand 2 3.71165
CBR3 carbonyl reductase 3 3.67885
CDCA4 cell division cycle associated 4 3.64665
ZNF589 zinc finger protein 589 3.4931
STXBP1 syntaxin binding protein 1 3.216
FCHO1 FCH domain only 1 3.18925
CCNF cyclin F 3.11707
CCL2 chemokine (C-C motif) ligand 2 2.73485
CHN1 chimerin 1 2.6506
PRR15L proline rich 15-like 2.6387
ADAT1 adenosine deaminase, tRNA-specific 1 2.62495
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.613
MYBPC1 myosin binding protein C, slow type 2.6005
CDPF1 cysteine-rich, DPF motif domain containing 1 2.51835
EVL Enah/Vasp-like 2.3878
MAPK12 mitogen-activated protein kinase 12 2.38745
SIRT3 sirtuin 3 2.37065
HSPA1A heat shock 70kDa protein 1A 2.35745
METRN meteorin, glial cell differentiation regulator 2.35655
LPCAT3 lysophosphatidylcholine acyltransferase 3 2.2567
GABARAPL1 GABA(A) receptor-associated protein like 1 2.25565
GLTP glycolipid transfer protein 2.2081
NCOA3 nuclear receptor coactivator 3 2.18883
SFTPB surfactant protein B 2.18795
TLR4 toll-like receptor 4 2.18735
TCAP titin-cap 2.17475
RIC8A RIC8 guanine nucleotide exchange factor A 2.17255
WASF3 WAS protein family, member 3 2.1647
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.0702
FOXK2 forkhead box K2 2.06125
GOLM1 golgi membrane protein 1 2.0435
HSDL2 hydroxysteroid dehydrogenase like 2 2.01667
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 2.01492
MYOM2 myomesin 2 2.00405

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -10.0
TRIB3 tribbles pseudokinase 3 -5.0
FAIM Fas apoptotic inhibitory molecule -4.8314
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.78235
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.66275
CCNB2 cyclin B2 -4.2732
CDC20 cell division cycle 20 -4.2605
FGFR4 fibroblast growth factor receptor 4 -4.20183
NGRN neugrin, neurite outgrowth associated -4.1371
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.63575
SCAND1 SCAN domain containing 1 -3.07025
OXA1L oxidase (cytochrome c) assembly 1-like -3.0144
CLIC4 chloride intracellular channel 4 -2.64305
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.46873
PTPRK protein tyrosine phosphatase, receptor type, K -2.4162
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.3327
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.29625
ZW10 zw10 kinetochore protein -2.26505
ADIRF adipogenesis regulatory factor -2.1613
INTS15 integrator complex subunit 15 -2.04903
RWDD1 RWD domain containing 1 -2.0396
CA9 carbonic anhydrase IX -2.01685