CRCGN008_HEPG2_24H:D07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-ethyl-2-hexenal 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN008_HEPG2_24H:D07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HLA-DMA major histocompatibility complex, class II, DM alpha 5.11585
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.08485
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.9883
UBQLN2 ubiquilin 2 4.66275
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.5903
NOSIP nitric oxide synthase interacting protein 4.28615
CHMP6 charged multivesicular body protein 6 4.2227
GPATCH8 G patch domain containing 8 3.3128
CYCS cytochrome c, somatic 3.17235
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.94092
PTK2 protein tyrosine kinase 2 2.82515
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.7613
ZNF589 zinc finger protein 589 2.67565
EVL Enah/Vasp-like 2.64315
SOCS2 suppressor of cytokine signaling 2 2.61287
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2.55645
RPL37 ribosomal protein L37 2.5478
HOOK2 hook microtubule-tethering protein 2 2.35025
TBP TATA box binding protein 2.3252
EPHA3 EPH receptor A3 2.17338
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.14775
RPL34 ribosomal protein L34 2.1054
AXIN1 axin 1 2.0335

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.67375
PCNA proliferating cell nuclear antigen -5.54445
LDHD lactate dehydrogenase D -5.1738
DNM1L dynamin 1-like -4.93085
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.92947
FGFR4 fibroblast growth factor receptor 4 -4.35345
PRPF4 pre-mRNA processing factor 4 -3.45312
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.3441
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.26332
RNF167 ring finger protein 167 -2.85865
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.8103
ACLY ATP citrate lyase -2.69698
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.6196
CCNB1 cyclin B1 -2.3903
TICAM1 toll-like receptor adaptor molecule 1 -2.1857
SYNPO2 synaptopodin 2 -2.1749
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.05165
ADGRB2 adhesion G protein-coupled receptor B2 -2.0208