CRCGN008_HEPG2_24H:D08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-ethyl-2-hexenal 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

108 genes differentially expressed following the CRCGN008_HEPG2_24H:D08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
MYLK myosin light chain kinase 5.4094
GSTZ1 glutathione S-transferase zeta 1 5.14465
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.0569
ARL4C ADP-ribosylation factor-like 4C 4.58412
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.27125
LOC122526780 uncharacterized LOC122526780 4.1827
GRWD1 glutamate-rich WD repeat containing 1 3.92735
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.90415
LCN2 lipocalin 2 3.7285
TBPL1 TBP-like 1 3.6154
CHN1 chimerin 1 3.52875
CD40 CD40 molecule, TNF receptor superfamily member 5 3.40069
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.07655
SNAP25 synaptosomal-associated protein, 25kDa 2.8405
SSBP2 single-stranded DNA binding protein 2 2.74417
CYCS cytochrome c, somatic 2.31255
BRD4 bromodomain containing 4 2.0946
CDC45 cell division cycle 45 2.094
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 2.0802
TBP TATA box binding protein 2.0764
KIFAP3 kinesin-associated protein 3 2.06265
KLHL21 kelch-like family member 21 2.05735
HIRIP3 HIRA interacting protein 3 2.04025
TLK2 tousled-like kinase 2 2.0258

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.5348
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.42805
ADI1 acireductone dioxygenase 1 -5.33545
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.0
ZNF586 zinc finger protein 586 -4.70985
CDC20 cell division cycle 20 -4.6933
GOLT1B golgi transport 1B -4.6743
PCNA proliferating cell nuclear antigen -4.6007
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.5436
TM9SF3 transmembrane 9 superfamily member 3 -4.51605
HSPB1 heat shock 27kDa protein 1 -4.47135
HLA-DMA major histocompatibility complex, class II, DM alpha -4.1571
HEATR1 HEAT repeat containing 1 -3.74
DCK deoxycytidine kinase -3.47295
HMG20B high mobility group 20B -3.17135
CCNB1 cyclin B1 -3.1251
HSPA8 heat shock 70kDa protein 8 -3.11455
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.0505
OXA1L oxidase (cytochrome c) assembly 1-like -2.99995
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma -2.9305
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.67425
TXNDC9 thioredoxin domain containing 9 -2.58833
ANPEP alanyl (membrane) aminopeptidase -2.5302
NRIP1 nuclear receptor interacting protein 1 -2.51975
ZNF667 zinc finger protein 667 -2.4787
GCM1 glial cells missing homolog 1 (Drosophila) -2.47575
DUSP14 dual specificity phosphatase 14 -2.45325
GPR39 G protein-coupled receptor 39 -2.42845
CINP cyclin-dependent kinase 2 interacting protein -2.40635
CCR9 chemokine (C-C motif) receptor 9 -2.4052
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.38877
MYO1D myosin ID -2.38085
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 -2.3714
BCO1 beta-carotene oxygenase 1 -2.36065
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 -2.33555
ANKH ANKH inorganic pyrophosphate transport regulator -2.32515
PTGIS prostaglandin I2 (prostacyclin) synthase -2.31097
ZNF480 zinc finger protein 480 -2.3073
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like -2.29665
ZNF135 zinc finger protein 135 -2.2823
ADORA3 adenosine A3 receptor -2.282
KL klotho -2.2732
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -2.24855
IST1 increased sodium tolerance 1 homolog (yeast) -2.21895
VN1R1 vomeronasal 1 receptor 1 -2.21605
ZNF587B zinc finger protein 587B -2.2118
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 -2.20315
PRDX1 peroxiredoxin 1 -2.2017
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.18497
CNTN5 contactin 5 -2.18365
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 -2.167
ZNF675 zinc finger protein 675 -2.1584
RAB30 RAB30, member RAS oncogene family -2.15615
ZNF304 zinc finger protein 304 -2.1524
RNLS renalase, FAD-dependent amine oxidase -2.1482
MAP3K7CL MAP3K7 C-terminal like -2.14005
ZFHX3 zinc finger homeobox 3 -2.13065
HRH4 histamine receptor H4 -2.10818
VSIG10 V-set and immunoglobulin domain containing 10 -2.10145
DGKE diacylglycerol kinase, epsilon 64kDa -2.101
OSBPL10 oxysterol binding protein-like 10 -2.099
AMIGO2 adhesion molecule with Ig-like domain 2 -2.0917
TAS2R4 taste receptor, type 2, member 4 -2.0903
NMBR neuromedin B receptor -2.08745
PSG2 pregnancy specific beta-1-glycoprotein 2 -2.0844
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 -2.073
ZNF253 zinc finger protein 253 -2.07135
TAS2R10 taste receptor, type 2, member 10 -2.0647
OR2B2 olfactory receptor, family 2, subfamily B, member 2 -2.05905
MYOC myocilin, trabecular meshwork inducible glucocorticoid response -2.0509
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 -2.0466
BHMT betaine--homocysteine S-methyltransferase -2.0464
ITGA10 integrin, alpha 10 -2.0415
SLITRK2 SLIT and NTRK-like family, member 2 -2.04125
LRRC31 leucine rich repeat containing 31 -2.04055
MAGEB4 melanoma antigen family B4 -2.03985
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.0381
ZNF587 zinc finger protein 587 -2.0348
ZNF471 zinc finger protein 471 -2.032
ENG endoglin -2.03128
LNPEP leucyl/cystinyl aminopeptidase -2.02815
MBD5 methyl-CpG binding domain protein 5 -2.0175
OR2W1 olfactory receptor, family 2, subfamily W, member 1 -2.0034