CRCGN008_HEPG2_24H:D12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-ethyl-2-hexenal 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

113 genes differentially expressed following the CRCGN008_HEPG2_24H:D12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 5.33035
RPP38 ribonuclease P/MRP 38kDa subunit 5.2446
AMDHD2 amidohydrolase domain containing 2 5.2219
ATP11B ATPase, class VI, type 11B 5.08465
LYN LYN proto-oncogene, Src family tyrosine kinase 5.07205
UBQLN2 ubiquilin 2 4.91495
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.79725
CXCR4 chemokine (C-X-C motif) receptor 4 4.64995
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.6237
SLC75A1 solute carrier family 75 member 1 4.3978
CYCS cytochrome c, somatic 4.2388
KLHL9 kelch-like family member 9 4.06888
PEX11A peroxisomal biogenesis factor 11 alpha 3.59775
PFKL phosphofructokinase, liver 3.57163
GPER1 G protein-coupled estrogen receptor 1 3.52443
SIRT3 sirtuin 3 3.33465
VGLL4 vestigial-like family member 4 3.25495
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.12552
HSPA1A heat shock 70kDa protein 1A 3.0823
STXBP2 syntaxin binding protein 2 2.873
SSBP2 single-stranded DNA binding protein 2 2.8533
OCA2 oculocutaneous albinism II 2.8087
LPAR2 lysophosphatidic acid receptor 2 2.78263
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.78125
PLSCR3 phospholipid scramblase 3 2.69373
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.6392
TRIM13 tripartite motif containing 13 2.56155
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.55807
WDTC1 WD and tetratricopeptide repeats 1 2.50905
ETV7 ets variant 7 2.5072
MAP7 microtubule-associated protein 7 2.49177
FOS FBJ murine osteosarcoma viral oncogene homolog 2.40825
RENBP renin binding protein 2.40825
EDA2R ectodysplasin A2 receptor 2.37875
SMAD9 SMAD family member 9 2.35505
TMPRSS5 transmembrane protease, serine 5 2.32975
BTNL3 butyrophilin-like 3 2.3228
GAST gastrin 2.3225
PSG11 pregnancy specific beta-1-glycoprotein 11 2.31775
BARX2 BARX homeobox 2 2.24735
CLCN2 chloride channel, voltage-sensitive 2 2.23955
ENTREP2 endosomal transmembrane epsin interactor 2 2.1917
LGI2 leucine-rich repeat LGI family, member 2 2.1795
STAB2 stabilin 2 2.17315
LOC102723996 ICOS ligand 2.16391
CNTFR ciliary neurotrophic factor receptor 2.15075
ECEL1 endothelin converting enzyme-like 1 2.1434
TEX13B testis expressed 13B 2.14
SHARPIN SHANK-associated RH domain interactor 2.1254
UNC119 unc-119 homolog (C. elegans) 2.1251
MELTF melanotransferrin 2.1206
HRH2 histamine receptor H2 2.1201
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 2.11355
RGS9BP regulator of G protein signaling 9 binding protein 2.10935
TG thyroglobulin 2.10845
POM121L2 POM121 transmembrane nucleoporin-like 2 2.0933
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2.0787
CAV3 caveolin 3 2.0767
SIX3 SIX homeobox 3 2.07655
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.07505
HGH1 HGH1 homolog (S. cerevisiae) 2.07328
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.05775
TRDMT1 tRNA aspartic acid methyltransferase 1 2.0576
TAC4 tachykinin 4 (hemokinin) 2.05315
RBP3 retinol binding protein 3, interstitial 2.0451
GRPR gastrin-releasing peptide receptor 2.03945
ERN1 endoplasmic reticulum to nucleus signaling 1 2.03425
TRAPPC10 trafficking protein particle complex 10 2.03243
SOCS2 suppressor of cytokine signaling 2 2.01688
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.0132
PDE5A phosphodiesterase 5A, cGMP-specific 2.01205
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 2.00765
HOXC8 homeobox C8 2.0075
TMSB4Y thymosin beta 4, Y-linked 2.0025

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.8661
ADI1 acireductone dioxygenase 1 -5.1514
TRIB3 tribbles pseudokinase 3 -5.13145
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.11555
WASHC4 WASH complex subunit 4 -5.09482
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -5.07193
GDF15 growth differentiation factor 15 -5.0
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.5796
VDAC1 voltage-dependent anion channel 1 -4.24785
FGFR4 fibroblast growth factor receptor 4 -3.96935
SCAND1 SCAN domain containing 1 -3.5954
TEX10 testis expressed 10 -2.9472
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.84335
OXA1L oxidase (cytochrome c) assembly 1-like -2.83695
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.80627
SCML1 sex comb on midleg-like 1 (Drosophila) -2.7338
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.7327
CSRP1 cysteine and glycine-rich protein 1 -2.52042
PRPF4 pre-mRNA processing factor 4 -2.44867
HSPA8 heat shock 70kDa protein 8 -2.4373
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.42013
RTF2 replication termination factor 2 -2.4018
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.36893
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.3293
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.29987
EIF6 eukaryotic translation initiation factor 6 -2.2943
PYCR1 pyrroline-5-carboxylate reductase 1 -2.2619
DNTT DNA nucleotidylexotransferase -2.23985
HSPB8 heat shock 22kDa protein 8 -2.2178
WWC2 WW and C2 domain containing 2 -2.17925
AMOTL2 angiomotin like 2 -2.17615
DCXR dicarbonyl/L-xylulose reductase -2.0956
CLTB clathrin, light chain B -2.09206
FBXL12 F-box and leucine-rich repeat protein 12 -2.0797
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.0577
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 -2.04513
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor -2.02842
YAP1 Yes-associated protein 1 -2.01455
RND1 Rho family GTPase 1 -2.0079