CRCGN008_HEPG2_24H:D13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-nitrosotoluene 40.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN008_HEPG2_24H:D13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.97845
RPP38 ribonuclease P/MRP 38kDa subunit 5.80245
UBQLN2 ubiquilin 2 5.3884
AMDHD2 amidohydrolase domain containing 2 4.93085
PPARG peroxisome proliferator-activated receptor gamma 4.90085
LYN LYN proto-oncogene, Src family tyrosine kinase 4.77523
MOK MOK protein kinase 4.6745
BACE2 beta-site APP-cleaving enzyme 2 4.5224
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.4287
HOXA10 homeobox A10 4.41248
CHN1 chimerin 1 4.34915
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.24866
NUP133 nucleoporin 133kDa 4.0853
CDPF1 cysteine-rich, DPF motif domain containing 1 3.88905
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 3.8148
TXNRD1 thioredoxin reductase 1 3.75195
CYCS cytochrome c, somatic 3.53625
CHMP6 charged multivesicular body protein 6 3.4803
RXYLT1 ribitol xylosyltransferase 1 3.31253
DYNLT3 dynein, light chain, Tctex-type 3 3.2777
ZFP36 ZFP36 ring finger protein 3.2632
SSBP2 single-stranded DNA binding protein 2 3.08022
UGDH UDP-glucose 6-dehydrogenase 3.0527
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.02205
STXBP2 syntaxin binding protein 2 2.95775
GRWD1 glutamate-rich WD repeat containing 1 2.87265
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 2.7738
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.7296
MTERF3 mitochondrial transcription termination factor 3 2.66805
SCYL3 SCY1-like 3 (S. cerevisiae) 2.642
NMU neuromedin U 2.60925
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.5795
TXNL4B thioredoxin-like 4B 2.57895
BIRC2 baculoviral IAP repeat containing 2 2.42455
LOC122526780 uncharacterized LOC122526780 2.3588
HMOX1 heme oxygenase 1 2.3583
TBP TATA box binding protein 2.31025
PPIF peptidylprolyl isomerase F 2.277
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.2418
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.2394
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.19965
TBK1 TANK-binding kinase 1 2.1476
ABHD4 abhydrolase domain containing 4 2.14465
RAB9A RAB9A, member RAS oncogene family 2.12905
MTPAP mitochondrial poly(A) polymerase 2.1202
TMEM101 transmembrane protein 101 2.1087
KEAP1 kelch-like ECH-associated protein 1 2.10555
NUTF2 nuclear transport factor 2 2.08465
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.06175
CUL1 cullin 1 2.0482
RIOX2 ribosomal oxygenase 2 2.04612
SFTPB surfactant protein B 2.0448
GMEB1 glucocorticoid modulatory element binding protein 1 2.0284
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.02445
WDR3 WD repeat domain 3 2.0228

decreased expression

Symbol Name Standardized Value
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -4.6801
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -4.67023
DCK deoxycytidine kinase -4.5854
ARID5B AT rich interactive domain 5B (MRF1-like) -4.2682
HLA-DMA major histocompatibility complex, class II, DM alpha -3.85555
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.42858
CCNB2 cyclin B2 -3.37295
MAPK13 mitogen-activated protein kinase 13 -3.3719
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.33375
HSPA8 heat shock 70kDa protein 8 -3.246
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.21005
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.1222
MAP7 microtubule-associated protein 7 -3.09462
RNF167 ring finger protein 167 -3.0857
CCNB1 cyclin B1 -3.0182
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.8739
OXA1L oxidase (cytochrome c) assembly 1-like -2.736
TXNDC9 thioredoxin domain containing 9 -2.6643
S100A4 S100 calcium binding protein A4 -2.66195
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.65028
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.64488
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.63482
CLIC4 chloride intracellular channel 4 -2.58382
DUSP2 dual specificity phosphatase 2 -2.5128
ZW10 zw10 kinetochore protein -2.41795
NRIP1 nuclear receptor interacting protein 1 -2.3242
MEIS1 Meis homeobox 1 -2.278
LASP1 LIM and SH3 protein 1 -2.27675
YPEL5 yippee-like 5 (Drosophila) -2.24615
HSPA6 heat shock 70kDa protein 6 (HSP70B') -2.17058
CCNH cyclin H -2.13315
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.13235
FHL2 four and a half LIM domains 2 -2.03365