CRCGN008_HEPG2_24H:D15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-nitrosotoluene 10.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

110 genes differentially expressed following the CRCGN008_HEPG2_24H:D15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ATP11B ATPase, class VI, type 11B 6.4892
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.25775
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.18245
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.1128
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.32535
CXCR4 chemokine (C-X-C motif) receptor 4 4.16405
SSBP2 single-stranded DNA binding protein 2 3.99773
EDN1 endothelin 1 3.6846
PLSCR1 phospholipid scramblase 1 3.57367
CYCS cytochrome c, somatic 3.5376
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.386
MKNK1 MAP kinase interacting serine/threonine kinase 1 3.3114
DNM1 dynamin 1 3.2987
TIAM1 T-cell lymphoma invasion and metastasis 1 3.27238
MCOLN1 mucolipin 1 3.2529
PRR15L proline rich 15-like 3.21495
MMP2 matrix metallopeptidase 2 3.10965
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.06015
FRS2 fibroblast growth factor receptor substrate 2 3.0583
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.02685
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.9909
MSRA methionine sulfoxide reductase A 2.96025
CHN1 chimerin 1 2.9506
FHL2 four and a half LIM domains 2 2.8628
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.8301
PMM2 phosphomannomutase 2 2.80955
CTSL cathepsin L 2.8034
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.76665
LPAR2 lysophosphatidic acid receptor 2 2.73333
LOC122526780 uncharacterized LOC122526780 2.6686
SFTPB surfactant protein B 2.64237
PLSCR3 phospholipid scramblase 3 2.62327
NT5DC2 5'-nucleotidase domain containing 2 2.60395
ANO1 anoctamin 1, calcium activated chloride channel 2.59645
EML3 echinoderm microtubule associated protein like 3 2.55657
GPER1 G protein-coupled estrogen receptor 1 2.52343
ICAM1 intercellular adhesion molecule 1 2.50652
TBX2 T-box 2 2.49613
CDK20 cyclin-dependent kinase 20 2.38535
ACP6 acid phosphatase 6, lysophosphatidic 2.35695
RANBP10 RAN binding protein 10 2.35
CCL2 chemokine (C-C motif) ligand 2 2.34145
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.33685
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.28405
LDOC1 leucine zipper, down-regulated in cancer 1 2.28365
CDK6 cyclin-dependent kinase 6 2.2603
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.2192
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.2109
MOSPD3 motile sperm domain containing 3 2.18435
IGHMBP2 immunoglobulin mu binding protein 2 2.18425
IFI44L interferon-induced protein 44-like 2.16685
ARFIP2 ADP-ribosylation factor interacting protein 2 2.1544
LGALS8 lectin, galactoside-binding, soluble, 8 2.13552
MX1 MX dynamin-like GTPase 1 2.13485
WDR83OS WD repeat domain 83 opposite strand 2.0945
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.09022
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.07895
PYCR1 pyrroline-5-carboxylate reductase 1 2.07645
NLRP2B NLR family pyrin domain containing 2B 2.0673
PRUNE1 prune exopolyphosphatase 1 2.067
SNX7 sorting nexin 7 2.05135
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.05065
FAM193B family with sequence similarity 193, member B 2.04785
MARK3 MAP/microtubule affinity-regulating kinase 3 2.0102
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.00868

decreased expression

Symbol Name Standardized Value
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -8.1218
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.40275
LDHD lactate dehydrogenase D -5.15435
TM9SF3 transmembrane 9 superfamily member 3 -5.10795
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7331
RPN1 ribophorin I -4.71595
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -4.2233
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.1815
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.0852
TM9SF2 transmembrane 9 superfamily member 2 -3.97675
HLA-DMA major histocompatibility complex, class II, DM alpha -3.93145
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.8813
SLC35F2 solute carrier family 35, member F2 -3.75315
TLCD3A TLC domain containing 3A -3.6797
CCNB1 cyclin B1 -3.54555
ATF5 activating transcription factor 5 -3.1255
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.05078
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.9732
OXA1L oxidase (cytochrome c) assembly 1-like -2.79485
NLRP4 NLR family, pyrin domain containing 4 -2.73215
DDB2 damage-specific DNA binding protein 2, 48kDa -2.68165
ACAA1 acetyl-CoA acyltransferase 1 -2.6476
LOC124907782 dual specificity protein phosphatase 22 -2.63755
ENOPH1 enolase-phosphatase 1 -2.63085
SCCPDH saccharopine dehydrogenase (putative) -2.50565
CAB39 calcium binding protein 39 -2.47385
HSPA8 heat shock 70kDa protein 8 -2.45928
ITGB1BP1 integrin beta 1 binding protein 1 -2.45828
COPG1 coatomer protein complex, subunit gamma 1 -2.44975
RNF167 ring finger protein 167 -2.40125
CHEK1 checkpoint kinase 1 -2.38705
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.37575
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.3507
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.33535
NFU1 NFU1 iron-sulfur cluster scaffold -2.3173
NANS N-acetylneuraminic acid synthase -2.21455
DYNLT3 dynein, light chain, Tctex-type 3 -2.2067
TMEM50A transmembrane protein 50A -2.1819
LIMA1 LIM domain and actin binding 1 -2.1788
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.1689
NUP93 nucleoporin 93kDa -2.1035
CRYZ crystallin, zeta (quinone reductase) -2.0816
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.0643
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.01725
RAB29 RAB29, member RAS oncogene family -2.01635