CRCGN008_HEPG2_24H:D17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-nitrosotoluene 2.55 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN008_HEPG2_24H:D17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.30935
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.23265
RPP38 ribonuclease P/MRP 38kDa subunit 4.85495
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.8328
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.51585
EVL Enah/Vasp-like 4.2535
GSTZ1 glutathione S-transferase zeta 1 3.57685
GPATCH8 G patch domain containing 8 3.43722
EGF epidermal growth factor 3.32055
PLSCR3 phospholipid scramblase 3 2.91458
GHR growth hormone receptor 2.81375
PIH1D1 PIH1 domain containing 1 2.8009
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.72675
JADE2 jade family PHD finger 2 2.50248
FOS FBJ murine osteosarcoma viral oncogene homolog 2.4977
TBP TATA box binding protein 2.3968
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 2.20215
GATA2 GATA binding protein 2 2.13603
CHEK2 checkpoint kinase 2 2.13475
CEMIP2 cell migration inducing hyaluronidase 2 2.11665
RCOR1 REST corepressor 1 2.0415

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.296
VAT1 vesicle amine transport 1 -5.52305
USP6NL USP6 N-terminal like -5.4067
CD320 CD320 molecule -4.85565
CCNB1 cyclin B1 -4.49065
HLA-DMA major histocompatibility complex, class II, DM alpha -4.3354
TLCD3A TLC domain containing 3A -4.33475
CCNB2 cyclin B2 -3.89625
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -3.72848
WASHC4 WASH complex subunit 4 -3.3001
CHIC2 cysteine-rich hydrophobic domain 2 -2.80555
INSIG1 insulin induced gene 1 -2.738
FHL2 four and a half LIM domains 2 -2.7102
KDM5C lysine (K)-specific demethylase 5C -2.52365
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.41735
KLHL25 kelch-like family member 25 -2.28315
TRAF3IP2 TRAF3 interacting protein 2 -2.25393
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 -2.2443
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.21235
RNF167 ring finger protein 167 -2.2073
TTPA tocopherol (alpha) transfer protein -2.2054
ENOPH1 enolase-phosphatase 1 -2.182
MKS1 Meckel syndrome, type 1 -2.1429
RBM34 RNA binding motif protein 34 -2.138
S1PR2 sphingosine-1-phosphate receptor 2 -2.1298
MAST4 microtubule associated serine/threonine kinase family member 4 -2.12065
OR7A17 olfactory receptor, family 7, subfamily A, member 17 -2.11895
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -2.10755
IKZF4 IKAROS family zinc finger 4 (Eos) -2.08655
HHLA2 HERV-H LTR-associating 2 -2.0702
RRAGB Ras-related GTP binding B -2.06395
RGSL1 regulator of G-protein signaling like 1 -2.06125
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 -2.05625
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 -2.04452
SGMS1 sphingomyelin synthase 1 -2.0286
HNMT histamine N-methyltransferase -2.0273
FSHB follicle stimulating hormone, beta polypeptide -2.02215
OR3A3 olfactory receptor, family 3, subfamily A, member 3 -2.0122
COQ8B coenzyme Q8B -2.01095
APH1B APH1B gamma secretase subunit -2.00515