CRCGN008_HEPG2_24H:D18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-nitrosotoluene 1.28 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN008_HEPG2_24H:D18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
PLS1 plastin 1 5.3218
DYNLT3 dynein, light chain, Tctex-type 3 5.1751
PPARG peroxisome proliferator-activated receptor gamma 4.92895
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.89975
PRKCH protein kinase C, eta 4.45445
NMU neuromedin U 4.27975
GPER1 G protein-coupled estrogen receptor 1 3.98833
SSBP2 single-stranded DNA binding protein 2 3.97885
ABHD6 abhydrolase domain containing 6 3.91983
SNAP25 synaptosomal-associated protein, 25kDa 3.7566
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.66599
CYCS cytochrome c, somatic 3.4634
CHN1 chimerin 1 3.345
GPATCH8 G patch domain containing 8 2.976
LPAR2 lysophosphatidic acid receptor 2 2.80018
ADAT1 adenosine deaminase, tRNA-specific 1 2.6669
PLSCR3 phospholipid scramblase 3 2.60928
EIF1B eukaryotic translation initiation factor 1B 2.55105
CDC45 cell division cycle 45 2.4787
SCG5 secretogranin V 2.30285
SCRN1 secernin 1 2.1873
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 2.13555
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.12763
ZNF589 zinc finger protein 589 2.09193
UBA5 ubiquitin-like modifier activating enzyme 5 2.01865
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.01675

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -5.48535
MRPS2 mitochondrial ribosomal protein S2 -5.34395
THAP11 THAP domain containing 11 -5.2438
FASTKD5 FAST kinase domains 5 -5.05105
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.99495
NGRN neugrin, neurite outgrowth associated -4.86525
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.8195
LDHD lactate dehydrogenase D -4.6794
NRIP1 nuclear receptor interacting protein 1 -4.48475
CCNB2 cyclin B2 -3.9909
PRPF4 pre-mRNA processing factor 4 -3.64848
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.54075
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.2658
OXA1L oxidase (cytochrome c) assembly 1-like -3.2375
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.82955
FHL2 four and a half LIM domains 2 -2.6023
UBAC1 UBA domain containing 1 -2.50065
NELFB negative elongation factor complex member B -2.49205
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.4294
XYLT2 xylosyltransferase II -2.34395
RFC2 replication factor C (activator 1) 2, 40kDa -2.31585
SURF2 surfeit 2 -2.29045
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -2.2722
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.13997
EDF1 endothelial differentiation-related factor 1 -2.12335
UBTD1 ubiquitin domain containing 1 -2.1142
PDE4B phosphodiesterase 4B, cAMP-specific -2.11158
FBXO34 F-box protein 34 -2.0892
COQ4 coenzyme Q4 -2.0298
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.0188
METTL25B methyltransferase like 25B -2.0129
TOR1B torsin family 1, member B (torsin B) -2.0093