CRCGN008_HEPG2_24H:D22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description citral 5.07 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

82 genes differentially expressed following the CRCGN008_HEPG2_24H:D22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 5.38355
TERT telomerase reverse transcriptase 5.17435
STIMATE STIM activating enhancer 5.0591
RPP38 ribonuclease P/MRP 38kDa subunit 4.9784
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.79255
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.77945
ABHD6 abhydrolase domain containing 6 4.64467
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.59198
PEX11A peroxisomal biogenesis factor 11 alpha 4.40858
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.3485
EGF epidermal growth factor 4.1887
PHKA1 phosphorylase kinase, alpha 1 (muscle) 4.0501
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.50621
TIAM1 T-cell lymphoma invasion and metastasis 1 3.2194
CYCS cytochrome c, somatic 3.1367
CDCA4 cell division cycle associated 4 2.86545
CCNA1 cyclin A1 2.8373
TBP TATA box binding protein 2.81455
SSBP2 single-stranded DNA binding protein 2 2.8041
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.7376
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.62993
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.61547
MTMR6 myotubularin related protein 6 2.6018
PLSCR3 phospholipid scramblase 3 2.57882
CEP97 centrosomal protein 97kDa 2.5617
NMU neuromedin U 2.5594
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 2.46755
KIF20A kinesin family member 20A 2.4426
NINJ1 ninjurin 1 2.39655
HSPA1A heat shock 70kDa protein 1A 2.35725
C2CD3 C2 calcium-dependent domain containing 3 2.31345
SPA17 sperm autoantigenic protein 17 2.2929
NUAK2 NUAK family, SNF1-like kinase, 2 2.25975
MCM9 minichromosome maintenance complex component 9 2.24705
CRTAP cartilage associated protein 2.23395
BPHL biphenyl hydrolase-like (serine hydrolase) 2.2222
SATB1 SATB homeobox 1 2.21115
HAUS6 HAUS augmin-like complex, subunit 6 2.1726
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.1273
UFM1 ubiquitin-fold modifier 1 2.11375
HEBP1 heme binding protein 1 2.10945
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.0576
MCUR1 mitochondrial calcium uniporter regulator 1 2.03675
SPATA7 spermatogenesis associated 7 2.0334

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -5.826
ZNF586 zinc finger protein 586 -5.26315
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.1859
CD320 CD320 molecule -5.1003
HAT1 histone acetyltransferase 1 -4.8298
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.55955
GNAS GNAS complex locus -3.56116
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -3.43545
CCNB1 cyclin B1 -3.29645
CDC25B cell division cycle 25B -2.94055
MTA1 metastasis associated 1 -2.82262
WASHC4 WASH complex subunit 4 -2.7796
SNX11 sorting nexin 11 -2.63355
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -2.52265
CHIC2 cysteine-rich hydrophobic domain 2 -2.51435
NEK7 NIMA-related kinase 7 -2.47265
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.44505
TXNDC9 thioredoxin domain containing 9 -2.357
PURA purine-rich element binding protein A -2.34775
ZNF783 zinc finger family member 783 -2.33455
ZNF587 zinc finger protein 587 -2.3233
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -2.24535
SMAGP small cell adhesion glycoprotein -2.2101
HLA-A major histocompatibility complex, class I, A -2.20692
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.2009
RCN1 reticulocalbin 1, EF-hand calcium binding domain -2.134
LOC128031832 uncharacterized LOC128031832 -2.1107
HMBOX1 homeobox containing 1 -2.11055
RIPOR2 RHO family interacting cell polarization regulator 2 -2.10782
SIAH2 siah E3 ubiquitin protein ligase 2 -2.10305
HGFAC HGF activator -2.09005
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -2.0803
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.06827
TAOK1 TAO kinase 1 -2.06105
OSBPL8 oxysterol binding protein-like 8 -2.03485
ZNF500 zinc finger protein 500 -2.03062
ZNF419 zinc finger protein 419 -2.01755
MPPE1 metallophosphoesterase 1 -2.00815