CRCGN008_HEPG2_24H:D24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description citral 1.27 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN008_HEPG2_24H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 5.1537
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 5.0258
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.98155
ATP11B ATPase, class VI, type 11B 4.9768
PPARG peroxisome proliferator-activated receptor gamma 4.80495
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.74945
E2F2 E2F transcription factor 2 4.735
CBR3 carbonyl reductase 3 4.43005
SNAP25 synaptosomal-associated protein, 25kDa 4.2417
CHN1 chimerin 1 3.70145
GSTZ1 glutathione S-transferase zeta 1 3.43295
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.2817
TESK1 testis-specific kinase 1 3.2616
CYCS cytochrome c, somatic 3.1377
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 3.09055
TBP TATA box binding protein 2.9836
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.7097
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.68375
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.6469
CEP57 centrosomal protein 57kDa 2.61583
STK10 serine/threonine kinase 10 2.59328
AXIN1 axin 1 2.5828
CCNF cyclin F 2.5695
ADAT1 adenosine deaminase, tRNA-specific 1 2.5597
HSF4 heat shock transcription factor 4 2.5402
LPAR2 lysophosphatidic acid receptor 2 2.52362
EPHA3 EPH receptor A3 2.52012
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.4421
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.4086
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.16505
TIAM1 T-cell lymphoma invasion and metastasis 1 2.08437
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.08365
MGAM maltase-glucoamylase 2.0797
FAM110D family with sequence similarity 110, member D 2.078
TAOK3 TAO kinase 3 2.0743
JADE2 jade family PHD finger 2 2.07117
PDLIM3 PDZ and LIM domain 3 2.0629
TCF15 transcription factor 15 (basic helix-loop-helix) 2.05855
SOX12 SRY (sex determining region Y)-box 12 2.0375
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.03285
PRLH prolactin releasing hormone 2.0082

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -5.5688
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.504
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.24385
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.23925
LDHD lactate dehydrogenase D -5.20925
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.978
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.67845
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.62445
HLA-DMA major histocompatibility complex, class II, DM alpha -4.54975
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.5107
RFC2 replication factor C (activator 1) 2, 40kDa -4.47242
HEATR1 HEAT repeat containing 1 -3.9858
CCNB1 cyclin B1 -3.7706
CCP110 centriolar coiled coil protein 110kDa -3.32595
HSPA8 heat shock 70kDa protein 8 -3.26342
CAPNS1 calpain, small subunit 1 -3.24125
OXA1L oxidase (cytochrome c) assembly 1-like -3.1229
RNF167 ring finger protein 167 -3.07175
SLC35F2 solute carrier family 35, member F2 -3.0051
CHIC2 cysteine-rich hydrophobic domain 2 -2.9044
TBCB tubulin folding cofactor B -2.83263
SNX11 sorting nexin 11 -2.76333
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.64805
FBXL12 F-box and leucine-rich repeat protein 12 -2.62365
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.59755
CX3CR1 chemokine (C-X3-C motif) receptor 1 -2.57045
ZNF146 zinc finger protein 146 -2.45535
TXNDC9 thioredoxin domain containing 9 -2.32585
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain -2.32435
RBM42 RNA binding motif protein 42 -2.26245
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough -2.22787
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.12205
LNPEP leucyl/cystinyl aminopeptidase -2.12075
ANKH ANKH inorganic pyrophosphate transport regulator -2.1172
ASL argininosuccinate lyase -2.0965
PSENEN presenilin enhancer gamma secretase subunit -2.03545
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.02335
CYB5R1 cytochrome b5 reductase 1 -2.01505