CRCGN008_HEPG2_24H:E02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description [(phosphonomethyl)amino]acetic acid compound with 2-propanamine (1:1) 10.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN008_HEPG2_24H:E02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPL39L ribosomal protein L39-like 5.8184
MOK MOK protein kinase 5.3846
HLA-DMA major histocompatibility complex, class II, DM alpha 5.18685
UBQLN2 ubiquilin 2 4.88595
CARMIL1 capping protein regulator and myosin 1 linker 1 4.46815
ARL4C ADP-ribosylation factor-like 4C 4.29988
VGLL4 vestigial-like family member 4 3.8927
NOSIP nitric oxide synthase interacting protein 3.78735
MAMLD1 mastermind-like domain containing 1 3.7694
HDGFL3 HDGF like 3 3.74635
RAB21 RAB21, member RAS oncogene family 3.7039
CDCA4 cell division cycle associated 4 3.15125
GADD45A growth arrest and DNA-damage-inducible, alpha 3.0529
TIAM1 T-cell lymphoma invasion and metastasis 1 2.8593
MAP7 microtubule-associated protein 7 2.76852
SSBP2 single-stranded DNA binding protein 2 2.7111
SKIC2 SKI2 subunit of superkiller complex 2.6592
USP6NL USP6 N-terminal like 2.4278
ADAT1 adenosine deaminase, tRNA-specific 1 2.1215
UFL1 UFM1-specific ligase 1 2.1109
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.07485
SIPA1L1 signal-induced proliferation-associated 1 like 1 2.05837
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.0036

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -5.7908
ALAS1 5'-aminolevulinate synthase 1 -5.3745
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.15955
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.0
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.87105
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.85895
ZDHHC6 zinc finger, DHHC-type containing 6 -4.7166
ZNF586 zinc finger protein 586 -4.6713
PCNA proliferating cell nuclear antigen -4.6007
CD320 CD320 molecule -4.4175
FGFR4 fibroblast growth factor receptor 4 -4.17835
NRIP1 nuclear receptor interacting protein 1 -3.92395
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.2004
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.92963
ZMIZ1 zinc finger, MIZ-type containing 1 -2.693
DERA deoxyribose-phosphate aldolase (putative) -2.4983
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.43677
JAM3 junctional adhesion molecule 3 -2.2597
AGRP agouti related neuropeptide -2.22425
ACSL5 acyl-CoA synthetase long-chain family member 5 -2.18215
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.16885
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -2.06063
BMP4 bone morphogenetic protein 4 -2.0499
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -2.0419
PAGE4 P antigen family, member 4 (prostate associated) -2.0401
GDF15 growth differentiation factor 15 -2.0373
SPAG4 sperm associated antigen 4 -2.01355
FFAR3 free fatty acid receptor 3 -2.0064