| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | [(phosphonomethyl)amino]acetic acid compound with 2-propanamine (1:1) 2.56 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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67 genes differentially expressed following the CRCGN008_HEPG2_24H:E04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TBPL1 | TBP-like 1 | 5.89315 |
| BLMH | bleomycin hydrolase | 5.19085 |
| MYLK | myosin light chain kinase | 5.12325 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.0847 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.877 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.86295 |
| RPL39L | ribosomal protein L39-like | 4.72345 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 4.63812 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 4.5815 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 4.21435 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 4.146 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 4.12735 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 3.90019 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.80947 |
| SOCS2 | suppressor of cytokine signaling 2 | 3.76617 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.48845 |
| CYCS | cytochrome c, somatic | 3.4697 |
| H2BC12 | H2B clustered histone 12 | 3.38377 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.0652 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 2.98635 |
| NENF | neudesin neurotrophic factor | 2.88655 |
| PFKL | phosphofructokinase, liver | 2.8412 |
| CCNF | cyclin F | 2.48708 |
| URM1 | ubiquitin related modifier 1 | 2.43065 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.3167 |
| CHMP6 | charged multivesicular body protein 6 | 2.30985 |
| STIL | SCL/TAL1 interrupting locus | 2.30815 |
| YY1AP1 | YY1 associated protein 1 | 2.28085 |
| CCL17 | chemokine (C-C motif) ligand 17 | 2.228 |
| HMG20A | high mobility group 20A | 2.2207 |
| RPA3 | replication protein A3, 14kDa | 2.209 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | 2.1941 |
| MED27 | mediator complex subunit 27 | 2.1901 |
| CDCA8 | cell division cycle associated 8 | 2.11975 |
| ISCA1 | iron-sulfur cluster assembly 1 | 2.02723 |
| CPOX | coproporphyrinogen oxidase | 2.00155 |
| HSPA2 | heat shock 70kDa protein 2 | 2.0013 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -5.6945 |
| TRIB3 | tribbles pseudokinase 3 | -5.41095 |
| PCNA | proliferating cell nuclear antigen | -5.17355 |
| LDHD | lactate dehydrogenase D | -5.0891 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -4.79445 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -4.657 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.6457 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -4.4937 |
| GNAS | GNAS complex locus | -4.42249 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.66875 |
| PLA2G15 | phospholipase A2, group XV | -3.1535 |
| IFRD2 | interferon-related developmental regulator 2 | -2.94075 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -2.93275 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -2.8512 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.82072 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.81975 |
| RGS2 | regulator of G-protein signaling 2 | -2.71135 |
| SNX7 | sorting nexin 7 | -2.3464 |
| FZD4 | frizzled class receptor 4 | -2.27625 |
| CDC25B | cell division cycle 25B | -2.23825 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | -2.177 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | -2.1368 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | -2.0937 |
| KLRC3 | killer cell lectin-like receptor subfamily C, member 3 | -2.0865 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -2.08105 |
| MOK | MOK protein kinase | -2.0587 |
| LMO7 | LIM domain 7 | -2.05025 |
| TMEM115 | transmembrane protein 115 | -2.04315 |
| CD58 | CD58 molecule | -2.02928 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -2.0254 |
