CRCGN008_HEPG2_24H:E05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description [(phosphonomethyl)amino]acetic acid compound with 2-propanamine (1:1) 1.28 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

120 genes differentially expressed following the CRCGN008_HEPG2_24H:E05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ATP11B ATPase, class VI, type 11B 5.3922
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.36535
UBQLN2 ubiquilin 2 5.02095
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.00385
LCN2 lipocalin 2 4.74735
EPHB2 EPH receptor B2 4.7032
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.6999
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.5867
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.40195
EGF epidermal growth factor 3.9974
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.96392
GPER1 G protein-coupled estrogen receptor 1 3.9177
GSTZ1 glutathione S-transferase zeta 1 3.84485
ABHD4 abhydrolase domain containing 4 3.836
STIMATE STIM activating enhancer 3.5941
PEX11A peroxisomal biogenesis factor 11 alpha 3.47408
TBP TATA box binding protein 3.21615
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.96865
LPAR2 lysophosphatidic acid receptor 2 2.8261
BPHL biphenyl hydrolase-like (serine hydrolase) 2.8028
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.78517
VWA1 von Willebrand factor A domain containing 1 2.77785
SPAG1 sperm associated antigen 1 2.7663
SSBP2 single-stranded DNA binding protein 2 2.66232
DNAAF11 dynein axonemal assembly factor 11 2.62595
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.62585
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.58185
ISG15 ISG15 ubiquitin-like modifier 2.5703
WDTC1 WD and tetratricopeptide repeats 1 2.56005
PDZD8 PDZ domain containing 8 2.54545
PMM2 phosphomannomutase 2 2.50785
IFI44 interferon-induced protein 44 2.49017
SCTR secretin receptor 2.48505
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.46145
BCL9 B-cell CLL/lymphoma 9 2.45495
IFI44L interferon-induced protein 44-like 2.42485
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.4148
RPRD2 regulation of nuclear pre-mRNA domain containing 2 2.40055
KIF20A kinesin family member 20A 2.3957
HDAC1 histone deacetylase 1 2.3674
BARD1 BRCA1 associated RING domain 1 2.3667
USP18 ubiquitin specific peptidase 18 2.3653
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.3375
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.3236
SKIC2 SKI2 subunit of superkiller complex 2.25515
SPAG5 sperm associated antigen 5 2.25395
GPN2 GPN-loop GTPase 2 2.2434
PDGFRL platelet-derived growth factor receptor-like 2.21975
MINDY3 MINDY lysine 48 deubiquitinase 3 2.2123
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.21027
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.2101
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.2081
FOXD2 forkhead box D2 2.1903
IFITM2 interferon induced transmembrane protein 2 2.1709
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.1597
LGI2 leucine-rich repeat LGI family, member 2 2.0992
SASH1 SAM and SH3 domain containing 1 2.08385
CDC45 cell division cycle 45 2.0801
RBPJ recombination signal binding protein for immunoglobulin kappa J region 2.07472
EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2.064
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.0587
ZNF35 zinc finger protein 35 2.04805
NUPR1 nuclear protein, transcriptional regulator, 1 2.03195
JARID2 jumonji, AT rich interactive domain 2 2.03105
RALY RALY heterogeneous nuclear ribonucleoprotein 2.0221
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.01545

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
ADI1 acireductone dioxygenase 1 -5.22205
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.1208
CHMP4B charged multivesicular body protein 4B -4.99253
LDHD lactate dehydrogenase D -4.91915
GOLT1B golgi transport 1B -4.90815
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.78395
NT5DC2 5'-nucleotidase domain containing 2 -4.7326
FBXL12 F-box and leucine-rich repeat protein 12 -4.6752
HLA-DMA major histocompatibility complex, class II, DM alpha -4.67505
ARFIP2 ADP-ribosylation factor interacting protein 2 -4.6551
NUP85 nucleoporin 85kDa -4.46535
MRPS7 mitochondrial ribosomal protein S7 -4.3177
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.09655
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.64215
MAPK13 mitogen-activated protein kinase 13 -3.3947
HSPA8 heat shock 70kDa protein 8 -3.10002
OXA1L oxidase (cytochrome c) assembly 1-like -2.9763
CD58 CD58 molecule -2.79965
LYPD3 LY6/PLAUR domain containing 3 -2.72065
MRPL58 mitochondrial ribosomal protein L58 -2.70085
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.6537
IFRD2 interferon-related developmental regulator 2 -2.60623
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.5348
CAMTA2 calmodulin binding transcription activator 2 -2.3607
NUP107 nucleoporin 107kDa -2.33275
DERA deoxyribose-phosphate aldolase (putative) -2.3076
CEP170B centrosomal protein 170B -2.30745
TMEM94 transmembrane protein 94 -2.2896
KRT14 keratin 14, type I -2.2559
DMTN dematin actin binding protein -2.2437
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.19715
CCNB1 cyclin B1 -2.1915
ZNF266 zinc finger protein 266 -2.1778
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.1761
CLTB clathrin, light chain B -2.17118
KRT5 keratin 5, type II -2.1667
ANPEP alanyl (membrane) aminopeptidase -2.1254
RECQL RecQ helicase-like -2.11975
FGF3 fibroblast growth factor 3 -2.11185
SIAH2 siah E3 ubiquitin protein ligase 2 -2.11055
RBM34 RNA binding motif protein 34 -2.0978
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.09585
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -2.0827
CDH10 cadherin 10, type 2 (T2-cadherin) -2.0824
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -2.0749
SCCPDH saccharopine dehydrogenase (putative) -2.07485
SNX17 sorting nexin 17 -2.06875
ZNF692 zinc finger protein 692 -2.059
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -2.04495
ADIRF adipogenesis regulatory factor -2.04435
CORT cortistatin -2.0115
TAC3 tachykinin 3 -2.00235
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.001