| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | [(phosphonomethyl)amino]acetic acid compound with 2-propanamine (1:1) 0.64 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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59 genes differentially expressed following the CRCGN008_HEPG2_24H:E06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| E2F2 | E2F transcription factor 2 | 5.5315 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 5.30115 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.08345 |
| NOTCH1 | notch 1 | 4.80255 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 4.7904 |
| SMIM40 | small integral membrane protein 40 | 4.7673 |
| STIMATE | STIM activating enhancer | 4.5301 |
| CHN1 | chimerin 1 | 4.21655 |
| PRR15L | proline rich 15-like | 4.08115 |
| RAB21 | RAB21, member RAS oncogene family | 4.0056 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.96322 |
| NMU | neuromedin U | 3.80705 |
| KIF5C | kinesin family member 5C | 3.7373 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.6402 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 3.53254 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 3.08535 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.97527 |
| CEP57 | centrosomal protein 57kDa | 2.96641 |
| GPATCH8 | G patch domain containing 8 | 2.76635 |
| AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | 2.5259 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 2.4462 |
| WASF3 | WAS protein family, member 3 | 2.3828 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 2.37665 |
| GTF3A | general transcription factor IIIA | 2.3146 |
| CDC45 | cell division cycle 45 | 2.3116 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.2617 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.2497 |
| MYOM1 | myomesin 1 | 2.22485 |
| STXBP2 | syntaxin binding protein 2 | 2.1746 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | 2.15845 |
| CDCA4 | cell division cycle associated 4 | 2.0953 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 2.00225 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -5.57665 |
| ZNF586 | zinc finger protein 586 | -5.48365 |
| CD320 | CD320 molecule | -5.21235 |
| ADI1 | acireductone dioxygenase 1 | -5.1853 |
| LDHD | lactate dehydrogenase D | -5.0035 |
| TLCD3A | TLC domain containing 3A | -4.9248 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.6923 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.94482 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -3.9363 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.6963 |
| VDAC1 | voltage-dependent anion channel 1 | -3.67522 |
| JMJD6 | jumonji domain containing 6 | -3.60468 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.26195 |
| MAP7 | microtubule-associated protein 7 | -3.17542 |
| FHL2 | four and a half LIM domains 2 | -2.7077 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.61115 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.42575 |
| RBM15B | RNA binding motif protein 15B | -2.3586 |
| PRPF4 | pre-mRNA processing factor 4 | -2.354 |
| IQSEC2 | IQ motif and Sec7 domain 2 | -2.175 |
| MXRA7 | matrix-remodelling associated 7 | -2.17325 |
| RNF167 | ring finger protein 167 | -2.16935 |
| CCNB1 | cyclin B1 | -2.1571 |
| CCNH | cyclin H | -2.13255 |
| GDPD2 | glycerophosphodiester phosphodiesterase domain containing 2 | -2.1098 |
| GLI1 | GLI family zinc finger 1 | -2.0417 |
| PRKACG | protein kinase, cAMP-dependent, catalytic, gamma | -2.01275 |
