CRCGN008_HEPG2_24H:E07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tin (ii) chloride 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

265 genes differentially expressed following the CRCGN008_HEPG2_24H:E07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
CBR3 carbonyl reductase 3 10.0
LCN2 lipocalin 2 7.9907
PLSCR1 phospholipid scramblase 1 6.18835
TBPL1 TBP-like 1 5.5446
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.9944
CNPY3 canopy FGF signaling regulator 3 4.5323
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.184
RNF167 ring finger protein 167 3.7149
STX1A syntaxin 1A (brain) 3.491
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.3547
RHOA ras homolog family member A 3.2117
SCYL3 SCY1-like 3 (S. cerevisiae) 3.12065
LYRM1 LYR motif containing 1 3.0977
MAP7D3 MAP7 domain containing 3 2.9419
AOAH acyloxyacyl hydrolase (neutrophil) 2.9377
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2.8193
TUBB4A tubulin, beta 4A class IVa 2.8153
CGREF1 cell growth regulator with EF-hand domain 1 2.7889
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 2.6767
S100A1 S100 calcium binding protein A1 2.6505
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.6096
OXSR1 oxidative stress responsive 1 2.6021
LRP3 low density lipoprotein receptor-related protein 3 2.5985
RPIA ribose 5-phosphate isomerase A 2.5887
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.5777
NMD3 NMD3 ribosome export adaptor 2.5663
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2.5476
MRPL4 mitochondrial ribosomal protein L4 2.5451
GMEB1 glucocorticoid modulatory element binding protein 1 2.4593
FOXH1 forkhead box H1 2.4572
CZIB CXXC motif containing zinc binding protein 2.455
MTMR12 myotubularin related protein 12 2.4475
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.4031
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.3975
OXCT1 3-oxoacid CoA transferase 1 2.3885
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 2.3715
LEFTY2 left-right determination factor 2 2.3692
PRTN3 proteinase 3 2.3681
GSTT4 glutathione S-transferase theta 4 2.367
GALE UDP-galactose-4-epimerase 2.3663
SFXN1 sideroflexin 1 2.3636
BTK Bruton agammaglobulinemia tyrosine kinase 2.3461
AFG3L2 AFG3-like AAA ATPase 2 2.3341
RPA3 replication protein A3, 14kDa 2.3313
ERN2 endoplasmic reticulum to nucleus signaling 2 2.2892
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.2887
CSNK1A1 casein kinase 1, alpha 1 2.28307
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.2752
AXIN1 axin 1 2.2737
ALPG alkaline phosphatase, germ cell 2.26423
FAM107A family with sequence similarity 107, member A 2.26085
YIPF5 Yip1 domain family, member 5 2.2585
CENPS-CORT CENPS-CORT readthrough 2.2516
PTCH2 patched 2 2.2495
RUNX3 runt-related transcription factor 3 2.247
DNAL4 dynein, axonemal, light chain 4 2.2431
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.24165
RBBP4 retinoblastoma binding protein 4 2.23925
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.2314
NLRX1 NLR family member X1 2.2281
FBXL5 F-box and leucine-rich repeat protein 5 2.21135
RETN resistin 2.2068
THEMIS2 thymocyte selection associated family member 2 2.2047
UFM1 ubiquitin-fold modifier 1 2.2034
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.2029
G0S2 G0/G1 switch 2 2.1945
UTF1 undifferentiated embryonic cell transcription factor 1 2.1797
RRM1 ribonucleotide reductase M1 2.1769
MSTO1 misato 1, mitochondrial distribution and morphology regulator 2.1766
SLN sarcolipin 2.1712
MANF mesencephalic astrocyte-derived neurotrophic factor 2.1577
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.1505
APOO apolipoprotein O 2.1462
RPL10L ribosomal protein L10-like 2.1404
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.1228
USP8 ubiquitin specific peptidase 8 2.1198
GP9 glycoprotein IX (platelet) 2.1154
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.1149
CCNP cyclin P 2.112
ZC4H2 zinc finger, C4H2 domain containing 2.1035
CEPT1 choline/ethanolamine phosphotransferase 1 2.1034
AQP5 aquaporin 5 2.0977
HCAR3 hydroxycarboxylic acid receptor 3 2.0915
CRYAB crystallin, alpha B 2.0907
PGLYRP1 peptidoglycan recognition protein 1 2.0807
TECR trans-2,3-enoyl-CoA reductase 2.076
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 2.0673
CIDEB cell death-inducing DFFA-like effector b 2.0663
APLP1 amyloid beta (A4) precursor-like protein 1 2.0604
PUDP pseudouridine 5'-phosphatase 2.055
FOXL2 forkhead box L2 2.0533
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.0508
MICU2 mitochondrial calcium uptake 2 2.0486
PDGFA platelet-derived growth factor alpha polypeptide 2.0467
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 2.0462
LRRC42 leucine rich repeat containing 42 2.0458
SYNDIG1 synapse differentiation inducing 1 2.0433
SOX9 SRY (sex determining region Y)-box 9 2.0391
GPR88 G protein-coupled receptor 88 2.0389
MYBPC1 myosin binding protein C, slow type 2.037
ERMAP erythroblast membrane-associated protein (Scianna blood group) 2.0275
BMAL2 basic helix-loop-helix ARNT like 2 2.0257
PAX1 paired box 1 2.0252
GATA4 GATA binding protein 4 2.0212
AZU1 azurocidin 1 2.0125
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.006
TOMM34 translocase of outer mitochondrial membrane 34 2.0054

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
DHRS7 dehydrogenase/reductase (SDR family) member 7 -8.865
GNAS GNAS complex locus -7.65274
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -7.5622
RHEB Ras homolog enriched in brain -7.35293
MAPK13 mitogen-activated protein kinase 13 -6.4074
ACAA1 acetyl-CoA acyltransferase 1 -5.7973
NRIP1 nuclear receptor interacting protein 1 -5.345
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.138
NVL nuclear VCP-like -4.4384
MARK1 MAP/microtubule affinity-regulating kinase 1 -4.3036
TBX2 T-box 2 -3.8166
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.39175
TXNDC9 thioredoxin domain containing 9 -3.33275
GSTM2 glutathione S-transferase mu 2 (muscle) -3.2556
FHL2 four and a half LIM domains 2 -3.162
CSRNP3 cysteine-serine-rich nuclear protein 3 -3.0294
ERVMER34-1 endogenous retrovirus group MER34, member 1 -2.9929
CSAD cysteine sulfinic acid decarboxylase -2.9685
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -2.9567
CHIC2 cysteine-rich hydrophobic domain 2 -2.9464
CEP112 centrosomal protein 112kDa -2.9319
DOCK1 dedicator of cytokinesis 1 -2.9305
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -2.8535
ACVR2A activin A receptor, type IIA -2.8462
BEAN1 brain expressed, associated with NEDD4, 1 -2.748
TNS3 tensin 3 -2.7408
PCP4 Purkinje cell protein 4 -2.7068
EPYC epiphycan -2.6995
FGF20 fibroblast growth factor 20 -2.6867
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.6658
WDR26 WD repeat domain 26 -2.6518
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.6459
CEP162 centrosomal protein 162kDa -2.621
CHPF2 chondroitin polymerizing factor 2 -2.61025
MTX2 metaxin 2 -2.6097
TRIM45 tripartite motif containing 45 -2.6005
RNF43 ring finger protein 43 -2.5873
ACSL5 acyl-CoA synthetase long-chain family member 5 -2.5435
MKS1 Meckel syndrome, type 1 -2.5356
ACP2 acid phosphatase 2, lysosomal -2.5334
FGF3 fibroblast growth factor 3 -2.5312
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.5295
SOX11 SRY (sex determining region Y)-box 11 -2.52623
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.5192
SPATA17 spermatogenesis associated 17 -2.5079
PCDHB6 protocadherin beta 6 -2.4991
TSGA10 testis specific, 10 -2.4916
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.4805
NLRP4 NLR family, pyrin domain containing 4 -2.4756
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -2.4684
CEP135 centrosomal protein 135kDa -2.4601
CCR3 chemokine (C-C motif) receptor 3 -2.4491
BRAF B-Raf proto-oncogene, serine/threonine kinase -2.443
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.43025
RBMS1 RNA binding motif, single stranded interacting protein 1 -2.42305
PCDHB8 protocadherin beta 8 -2.4134
CCL11 chemokine (C-C motif) ligand 11 -2.4091
WDR33 WD repeat domain 33 -2.4062
GLT8D2 glycosyltransferase 8 domain containing 2 -2.3946
FBXL7 F-box and leucine-rich repeat protein 7 -2.3804
ZNF514 zinc finger protein 514 -2.3792
SUOX sulfite oxidase -2.379
WDR19 WD repeat domain 19 -2.3755
TAS2R10 taste receptor, type 2, member 10 -2.3624
GREM2 gremlin 2, DAN family BMP antagonist -2.362
ZNF239 zinc finger protein 239 -2.3602
BCHE butyrylcholinesterase -2.3419
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.3256
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -2.3153
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough -2.3134
MOXD1 monooxygenase, DBH-like 1 -2.3123
TMEM158 transmembrane protein 158 (gene/pseudogene) -2.2985
PPP1R3C protein phosphatase 1, regulatory subunit 3C -2.2955
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.2834
RIBC2 RIB43A domain with coiled-coils 2 -2.2824
ZSCAN9 zinc finger and SCAN domain containing 9 -2.2802
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.2742
SLC6A16 solute carrier family 6, member 16 -2.2718
TENT4A terminal nucleotidyltransferase 4A -2.2692
PRND prion protein 2 (dublet) -2.2617
TUBA1C tubulin, alpha 1c -2.25793
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.2576
ZNF493 zinc finger protein 493 -2.2519
PANX1 pannexin 1 -2.2508
UBQLN3 ubiquilin 3 -2.247
CKAP4 cytoskeleton-associated protein 4 -2.24235
ORC3 origin recognition complex, subunit 3 -2.2406
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -2.2373
ADIPOR1 adiponectin receptor 1 -2.2345
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 -2.2286
CRABP2 cellular retinoic acid binding protein 2 -2.2283
LECT2 leukocyte cell-derived chemotaxin 2 -2.2247
ST14 suppression of tumorigenicity 14 (colon carcinoma) -2.22
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.2186
PON3 paraoxonase 3 -2.2098
LOC124908558 X antigen family member 1-like -2.2008
AFAP1 actin filament associated protein 1 -2.1996
ATP9A ATPase, class II, type 9A -2.1986
ZNF660-ZNF197 ZNF660-ZNF197 readthrough -2.1961
H2BC21 H2B clustered histone 21 -2.1957
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.1879
ATP5F1E ATP synthase F1 subunit epsilon -2.1859
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.1858
CTAG2 cancer/testis antigen 2 -2.1835
KIF13A kinesin family member 13A -2.1822
TENM3 teneurin transmembrane protein 3 -2.1798
CIAO1 cytosolic iron-sulfur assembly component 1 -2.1752
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.1751
HSPA12A heat shock 70kDa protein 12A -2.1748
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.17
ZNF212 zinc finger protein 212 -2.1548
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.1526
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.1453
CUEDC1 CUE domain containing 1 -2.1397
RAB5IF RAB5 interacting factor -2.1354
LOC100533997 MAGEA10-MAGEA5 readthrough -2.1338
COX5B cytochrome c oxidase subunit Vb -2.13067
ZNF304 zinc finger protein 304 -2.1293
ZNF721 zinc finger protein 721 -2.1279
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 -2.1078
ZNF783 zinc finger family member 783 -2.1045
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.10297
TRIM24 tripartite motif containing 24 -2.10145
LMO1 LIM domain only 1 (rhombotin 1) -2.0978
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -2.0941
SLIT2 slit homolog 2 (Drosophila) -2.093
PHOX2B paired-like homeobox 2b -2.0899
PCDHB3 protocadherin beta 3 -2.0867
TUBA1B tubulin, alpha 1b -2.0863
NKIRAS2 NFKB inhibitor interacting Ras-like 2 -2.0857
EFHC1 EF-hand domain (C-terminal) containing 1 -2.0745
RNF139 ring finger protein 139 -2.0727
FBP1 fructose-1,6-bisphosphatase 1 -2.0695
SAGE1 sarcoma antigen 1 -2.0622
HAO2 hydroxyacid oxidase 2 (long chain) -2.0544
NUAK2 NUAK family, SNF1-like kinase, 2 -2.0528
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -2.05255
ADGRG2 adhesion G protein-coupled receptor G2 -2.0516
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.0508
CNTRL centriolin -2.046
CTNNA2 catenin (cadherin-associated protein), alpha 2 -2.0386
BAZ2B bromodomain adjacent to zinc finger domain, 2B -2.038
EXPH5 exophilin 5 -2.03385
SSX4B synovial sarcoma, X breakpoint 4B -2.0319
ACOX2 acyl-CoA oxidase 2, branched chain -2.0262
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 -2.02445
THBS3 thrombospondin 3 -2.0242
CPB2 carboxypeptidase B2 (plasma) -2.0213
ATF5 activating transcription factor 5 -2.01725
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 -2.01465
ZFP69B ZFP69 zinc finger protein B -2.0103
DAZL deleted in azoospermia-like -2.0076
SETD6 SET domain containing 6 -2.0075
CINP cyclin-dependent kinase 2 interacting protein -2.0074
SAXO6 stabilizer of axonemal microtubules 6 -2.00725
CANT1 calcium activated nucleotidase 1 -2.00705