CRCGN008_HEPG2_24H:E13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenyl-p-phenylenediamine 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

128 genes differentially expressed following the CRCGN008_HEPG2_24H:E13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
E2F2 E2F transcription factor 2 5.2546
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.23915
INPP1 inositol polyphosphate-1-phosphatase 5.1581
BZW2 basic leucine zipper and W2 domains 2 4.92215
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.9202
CBR1 carbonyl reductase 1 4.8915
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.78
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.6906
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.60785
CHN1 chimerin 1 4.5285
CNPY3 canopy FGF signaling regulator 3 4.4683
GPER1 G protein-coupled estrogen receptor 1 4.19278
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.0174
NNT nicotinamide nucleotide transhydrogenase 3.9005
CDC25B cell division cycle 25B 3.89175
JADE2 jade family PHD finger 2 3.79055
CEP57 centrosomal protein 57kDa 3.7793
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.7742
ALAS1 5'-aminolevulinate synthase 1 3.64575
BPHL biphenyl hydrolase-like (serine hydrolase) 3.5988
TRIB3 tribbles pseudokinase 3 3.4222
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.41215
NUCB2 nucleobindin 2 3.4098
FAIM Fas apoptotic inhibitory molecule 3.3992
MAP7 microtubule-associated protein 7 3.22688
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.07145
CD40 CD40 molecule, TNF receptor superfamily member 5 3.03069
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.0166
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.01095
GLRX glutaredoxin (thioltransferase) 3.00645
CDC45 cell division cycle 45 2.87205
VAT1 vesicle amine transport 1 2.8167
ADGRG1 adhesion G protein-coupled receptor G1 2.77265
DDIT4 DNA-damage-inducible transcript 4 2.6948
TBP TATA box binding protein 2.67015
GALE UDP-galactose-4-epimerase 2.65545
KLHL9 kelch-like family member 9 2.54665
MCUR1 mitochondrial calcium uniporter regulator 1 2.5227
COL16A1 collagen, type XVI, alpha 1 2.50035
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.48765
EPHA3 EPH receptor A3 2.47057
CEMIP2 cell migration inducing hyaluronidase 2 2.441
ISG15 ISG15 ubiquitin-like modifier 2.3622
MX1 MX dynamin-like GTPase 1 2.35595
FOXE1 forkhead box E1 2.3406
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.339
RAP1GAP RAP1 GTPase activating protein 2.32855
PHGDH phosphoglycerate dehydrogenase 2.29373
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.2798
SCRG1 stimulator of chondrogenesis 1 2.2526
BRD9 bromodomain containing 9 2.25235
CCNA1 cyclin A1 2.24285
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.2271
ABHD4 abhydrolase domain containing 4 2.209
IFI44 interferon-induced protein 44 2.20645
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.20635
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.2013
SQSTM1 sequestosome 1 2.2002
ZNF589 zinc finger protein 589 2.19662
DNAH17 dynein, axonemal, heavy chain 17 2.18975
ZNF669 zinc finger protein 669 2.17185
ALDOB aldolase B, fructose-bisphosphate 2.16224
GADD45A growth arrest and DNA-damage-inducible, alpha 2.11365
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.1136
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.1026
TARS1 threonyl-tRNA synthetase 1 2.09895
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.0825
SQOR sulfide quinone oxidoreductase 2.0781
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.07708
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 2.0594
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.0512
NANOS3 nanos homolog 3 (Drosophila) 2.026
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.0155
TCP11 t-complex 11, testis-specific 2.015
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.00334

decreased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -7.96315
ZDHHC6 zinc finger, DHHC-type containing 6 -5.35595
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.07395
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.9253
ADI1 acireductone dioxygenase 1 -4.9236
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.9071
FBXL12 F-box and leucine-rich repeat protein 12 -4.78775
ZW10 zw10 kinetochore protein -4.75535
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.726
LDHD lactate dehydrogenase D -4.67445
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.27855
HLA-DMA major histocompatibility complex, class II, DM alpha -4.21965
RFC2 replication factor C (activator 1) 2, 40kDa -4.20092
CD320 CD320 molecule -4.13575
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.0991
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.9316
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.6307
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.5794
ELAC2 elaC ribonuclease Z 2 -3.4191
FHL2 four and a half LIM domains 2 -3.31165
ALDOC aldolase C, fructose-bisphosphate -3.2663
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.21742
RNF167 ring finger protein 167 -3.1585
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.15312
TCERG1 transcription elongation regulator 1 -3.1205
LOC124907782 dual specificity protein phosphatase 22 -3.10935
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -3.10803
PLK1 polo-like kinase 1 -2.829
CCNB1 cyclin B1 -2.7852
OXA1L oxidase (cytochrome c) assembly 1-like -2.7737
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.7726
PCYOX1L prenylcysteine oxidase 1 like -2.71755
ZNF274 zinc finger protein 274 -2.65325
ISOC1 isochorismatase domain containing 1 -2.6387
NRIP1 nuclear receptor interacting protein 1 -2.56812
PGAM4 phosphoglycerate mutase family member 4 -2.559
ZNF267 zinc finger protein 267 -2.5142
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.46988
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.33605
XPO7 exportin 7 -2.25282
PNRC2 proline-rich nuclear receptor coactivator 2 -2.24825
SOAT2 sterol O-acyltransferase 2 -2.22135
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.1801
NHLRC2 NHL repeat containing 2 -2.1491
KCTD9 potassium channel tetramerization domain containing 9 -2.1477
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.0795
FBXO5 F-box protein 5 -2.06745
DBF4 DBF4 zinc finger -2.06605
AKAP8 A kinase (PRKA) anchor protein 8 -2.0655
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.0557
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -2.0307
NKRF NFKB repressing factor -2.00435