| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | diphenyl-p-phenylenediamine 19.9 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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152 genes differentially expressed following the CRCGN008_HEPG2_24H:E14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 9.2991 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 6.07145 |
| ADRB2 | adrenoceptor beta 2, surface | 6.00275 |
| AMDHD2 | amidohydrolase domain containing 2 | 5.5808 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 5.2665 |
| GPER1 | G protein-coupled estrogen receptor 1 | 4.44015 |
| INPP1 | inositol polyphosphate-1-phosphatase | 4.3867 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.3776 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 4.26445 |
| PRR15L | proline rich 15-like | 3.7554 |
| PFKL | phosphofructokinase, liver | 3.61588 |
| CDC25B | cell division cycle 25B | 3.5973 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 3.5742 |
| TMEM14A | transmembrane protein 14A | 3.2422 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | 3.038 |
| ARHGEF5 | Rho guanine nucleotide exchange factor (GEF) 5 | 3.03415 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 2.9751 |
| PHGDH | phosphoglycerate dehydrogenase | 2.93572 |
| PMM2 | phosphomannomutase 2 | 2.89155 |
| SKIC2 | SKI2 subunit of superkiller complex | 2.85125 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 2.8496 |
| CENPM | centromere protein M | 2.8241 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.80122 |
| CYCS | cytochrome c, somatic | 2.79055 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.7327 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.664 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.60395 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.5654 |
| CCNF | cyclin F | 2.4963 |
| FGGY | FGGY carbohydrate kinase domain containing | 2.4454 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 2.415 |
| RAP1GAP | RAP1 GTPase activating protein | 2.3699 |
| HDDC2 | HD domain containing 2 | 2.36968 |
| ABHD4 | abhydrolase domain containing 4 | 2.33175 |
| ZNF282 | zinc finger protein 282 | 2.31945 |
| MVP | major vault protein | 2.31145 |
| SQOR | sulfide quinone oxidoreductase | 2.30815 |
| COX17 | COX17 cytochrome c oxidase copper chaperone | 2.30585 |
| HSD17B8 | hydroxysteroid (17-beta) dehydrogenase 8 | 2.30235 |
| TRAPPC2L | trafficking protein particle complex 2-like | 2.30085 |
| TSPAN4 | tetraspanin 4 | 2.29565 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.2931 |
| VAT1 | vesicle amine transport 1 | 2.2857 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.28485 |
| GALE | UDP-galactose-4-epimerase | 2.28405 |
| OBP2B | odorant binding protein 2B | 2.2699 |
| OBP2A | odorant binding protein 2A | 2.2462 |
| BCL2L10 | BCL2-like 10 (apoptosis facilitator) | 2.2393 |
| PCDHB13 | protocadherin beta 13 | 2.2332 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | 2.21695 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | 2.1979 |
| ATP5MC1 | ATP synthase membrane subunit c locus 1 | 2.1956 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | 2.1951 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 2.1787 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.1785 |
| IFI35 | interferon-induced protein 35 | 2.1687 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.16375 |
| CMTR1 | cap methyltransferase 1 | 2.1634 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | 2.14287 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 2.1105 |
| RRP9 | ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) | 2.10295 |
| MICALL1 | MICAL-like 1 | 2.09465 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | 2.08702 |
| EPHA1 | EPH receptor A1 | 2.08625 |
| IL36A | interleukin 36, alpha | 2.0816 |
| APEH | acylaminoacyl-peptide hydrolase | 2.0646 |
| RHOB | ras homolog family member B | 2.062 |
| CPZ | carboxypeptidase Z | 2.05445 |
| GPATCH8 | G patch domain containing 8 | 2.02682 |
| COMMD3 | COMM domain containing 3 | 2.023 |
| CDK18 | cyclin-dependent kinase 18 | 2.0164 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.0134 |
| ATP5MF | ATP synthase membrane subunit f | 2.00645 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -9.21615 |
| GNAS | GNAS complex locus | -7.68609 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -6.5911 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -5.5819 |
| KDM3A | lysine (K)-specific demethylase 3A | -5.47125 |
| CD320 | CD320 molecule | -5.421 |
| ZW10 | zw10 kinetochore protein | -5.3512 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -5.0661 |
| TLCD3A | TLC domain containing 3A | -4.85735 |
| FASTKD5 | FAST kinase domains 5 | -4.5428 |
| PCNA | proliferating cell nuclear antigen | -4.50795 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -4.28385 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -4.21095 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.13895 |
| PRPF4 | pre-mRNA processing factor 4 | -3.6075 |
| HMG20B | high mobility group 20B | -3.53403 |
| YBX1 | Y box binding protein 1 | -3.2989 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.2803 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.18955 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | -3.0411 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.9918 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -2.91495 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.7185 |
| TCF12 | transcription factor 12 | -2.7041 |
| CYTL1 | cytokine-like 1 | -2.63555 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | -2.5453 |
| HSPBP1 | HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 | -2.5427 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.5414 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.5154 |
| MEOX2 | mesenchyme homeobox 2 | -2.5094 |
| TCERG1 | transcription elongation regulator 1 | -2.4738 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A | -2.4462 |
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | -2.42695 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.4133 |
| LGI1 | leucine-rich, glioma inactivated 1 | -2.41225 |
| PHB2 | prohibitin 2 | -2.39975 |
| SGTA | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha | -2.37475 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | -2.36055 |
| MINPP1 | multiple inositol-polyphosphate phosphatase 1 | -2.35525 |
| EED | embryonic ectoderm development | -2.3401 |
| EEF2 | eukaryotic translation elongation factor 2 | -2.30125 |
| ZC2HC1C | zinc finger, C2HC-type containing 1C | -2.28155 |
| OTUD3 | OTU deubiquitinase 3 | -2.28015 |
| HOXB2 | homeobox B2 | -2.2462 |
| ZXDB | zinc finger, X-linked, duplicated B | -2.2393 |
| ZBTB40 | zinc finger and BTB domain containing 40 | -2.2282 |
| AVPI1 | arginine vasopressin-induced 1 | -2.2157 |
| TMEM230 | transmembrane protein 230 | -2.20285 |
| RPL27A | ribosomal protein L27a | -2.20065 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -2.18245 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | -2.1521 |
| GPC5 | glypican 5 | -2.14515 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -2.131 |
| ITGB6 | integrin, beta 6 | -2.11757 |
| SMIM10L1 | small integral membrane protein 10 like 1 | -2.11485 |
| BTBD3 | BTB (POZ) domain containing 3 | -2.10755 |
| PPME1 | protein phosphatase methylesterase 1 | -2.09527 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | -2.07755 |
| TXNL1 | thioredoxin-like 1 | -2.07155 |
| RPL4 | ribosomal protein L4 | -2.06683 |
| VIM | vimentin | -2.0477 |
| POTEF | POTE ankyrin domain family, member F | -2.04706 |
| FBL | fibrillarin | -2.03935 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -2.03265 |
| RPS11 | ribosomal protein S11 | -2.02765 |
| MIA | melanoma inhibitory activity | -2.025 |
| CPAMD8 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | -2.0244 |
| INTS14 | integrator complex subunit 14 | -2.02405 |
| SLC17A9 | solute carrier family 17 (vesicular nucleotide transporter), member 9 | -2.02365 |
| RPS25 | ribosomal protein S25 | -2.0221 |
| MAGEB4 | melanoma antigen family B4 | -2.017 |
| NGFR | nerve growth factor receptor | -2.0158 |
| ARMC7 | armadillo repeat containing 7 | -2.01515 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -2.0143 |
| RPL41 | ribosomal protein L41 | -2.0117 |
| TULP3 | tubby like protein 3 | -2.00837 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.0064 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -2.006 |
| POMK | protein-O-mannose kinase | -2.00338 |
