CRCGN008_HEPG2_24H:E15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenyl-p-phenylenediamine 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

155 genes differentially expressed following the CRCGN008_HEPG2_24H:E15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BPHL biphenyl hydrolase-like (serine hydrolase) 7.1726
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.31335
E2F2 E2F transcription factor 2 4.9582
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.80975
BZW2 basic leucine zipper and W2 domains 2 4.75785
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.72079
CHMP6 charged multivesicular body protein 6 4.69725
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.65225
LOC122526780 uncharacterized LOC122526780 4.6249
SNAP25 synaptosomal-associated protein, 25kDa 4.19445
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.66475
WDR7 WD repeat domain 7 3.50755
NUCB2 nucleobindin 2 3.4591
CD40 CD40 molecule, TNF receptor superfamily member 5 3.41617
ANO1 anoctamin 1, calcium activated chloride channel 3.0703
MAP7 microtubule-associated protein 7 3.06145
JADE2 jade family PHD finger 2 3.0321
NOSIP nitric oxide synthase interacting protein 3.01505
PIPOX pipecolic acid oxidase 2.9907
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.98263
BAAT bile acid CoA:amino acid N-acyltransferase 2.8847
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.87317
CDC25B cell division cycle 25B 2.82795
GADD45G growth arrest and DNA-damage-inducible, gamma 2.68125
RBFA ribosome binding factor A (putative) 2.65975
QDPR quinoid dihydropteridine reductase 2.65285
R3HCC1 R3H domain and coiled-coil containing 1 2.5953
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.58045
HAX1 HCLS1 associated protein X-1 2.57835
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.53093
SIRT2 sirtuin 2 2.50485
EXO1 exonuclease 1 2.50215
FOXE1 forkhead box E1 2.4928
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.49175
CYCS cytochrome c, somatic 2.4778
SARS2 seryl-tRNA synthetase 2, mitochondrial 2.42465
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.4085
SUSD4 sushi domain containing 4 2.39545
SH3BP4 SH3-domain binding protein 4 2.38575
GATA4 GATA binding protein 4 2.3797
GLI1 GLI family zinc finger 1 2.372
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.36215
S100A2 S100 calcium binding protein A2 2.35055
HPX hemopexin 2.3467
FXR2 fragile X mental retardation, autosomal homolog 2 2.34057
RAB1B RAB1B, member RAS oncogene family 2.33475
FTCD formimidoyltransferase cyclodeaminase 2.32855
PHF1 PHD finger protein 1 2.31282
NAXD NAD(P)HX dehydratase 2.3014
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.28375
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.27995
SHARPIN SHANK-associated RH domain interactor 2.27655
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 2.27485
DNA2 DNA replication helicase/nuclease 2 2.2668
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.26375
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.26055
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 2.26045
EGLN2 egl-9 family hypoxia-inducible factor 2 2.25975
CCNF cyclin F 2.25925
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 2.25705
ZBTB7B zinc finger and BTB domain containing 7B 2.2538
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.247
CUEDC2 CUE domain containing 2 2.24675
SKA1 spindle and kinetochore associated complex subunit 1 2.2338
CDC45 cell division cycle 45 2.2338
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.22985
DXO decapping exoribonuclease 2.21622
TRIM13 tripartite motif containing 13 2.20295
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.19105
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.18585
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 2.14935
SIPA1L3 signal-induced proliferation-associated 1 like 3 2.14368
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.14353
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.13462
ALAS1 5'-aminolevulinate synthase 1 2.1247
GSTO1 glutathione S-transferase omega 1 2.11865
WDTC1 WD and tetratricopeptide repeats 1 2.1145
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.106
DMAC2 distal membrane arm assembly component 2 2.10483
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.1031
SLC17A4 solute carrier family 17, member 4 2.1019
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 2.10095
ZNF692 zinc finger protein 692 2.09385
UPB1 ureidopropionase, beta 2.08895
MAT1A methionine adenosyltransferase I, alpha 2.08215
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 2.08127
FBXO2 F-box protein 2 2.0803
USF2 upstream transcription factor 2, c-fos interacting 2.06137
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.0416
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.01645
EVL Enah/Vasp-like 2.01495
CERS2 ceramide synthase 2 2.0142
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.0131
GOLIM4 golgi integral membrane protein 4 2.00927
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.0057
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.00255

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
DNM1L dynamin 1-like -10.0
LDHD lactate dehydrogenase D -10.0
CCNB2 cyclin B2 -9.23345
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.6754
SLC35F2 solute carrier family 35, member F2 -5.4094
PCNA proliferating cell nuclear antigen -5.193
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.86155
GOLT1B golgi transport 1B -4.69505
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.63415
FASTKD5 FAST kinase domains 5 -4.38425
ADI1 acireductone dioxygenase 1 -4.0056
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.95685
LOC124907782 dual specificity protein phosphatase 22 -3.88755
RPIA ribose 5-phosphate isomerase A -3.70565
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.68645
GNAS GNAS complex locus -3.54611
RFC2 replication factor C (activator 1) 2, 40kDa -3.3827
PEG10 paternally expressed 10 -3.2986
SYNGAP1 synaptic Ras GTPase activating protein 1 -3.27565
HMG20B high mobility group 20B -3.27382
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.22885
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -3.21365
NGRN neugrin, neurite outgrowth associated -3.04215
SCAND1 SCAN domain containing 1 -2.73425
BMAL2 basic helix-loop-helix ARNT like 2 -2.6996
RGS2 regulator of G-protein signaling 2 -2.5611
F13A1 coagulation factor XIII, A1 polypeptide -2.4669
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -2.45915
ERGIC2 ERGIC and golgi 2 -2.4421
ELOVL1 ELOVL fatty acid elongase 1 -2.4354
TXNDC9 thioredoxin domain containing 9 -2.43003
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.42845
TNMD tenomodulin -2.3455
SAP130 Sin3A-associated protein, 130kDa -2.33815
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.33705
MED21 mediator complex subunit 21 -2.31372
RESF1 retroelement silencing factor 1 -2.2701
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 -2.2532
UNC50 unc-50 homolog (C. elegans) -2.2436
CDCA8 cell division cycle associated 8 -2.2171
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.18525
NT5E 5'-nucleotidase, ecto (CD73) -2.182
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.17647
PRUNE2 prune homolog 2 (Drosophila) -2.1596
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -2.1483
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -2.12315
AGO2 argonaute RISC catalytic component 2 -2.1159
GYPC glycophorin C (Gerbich blood group) -2.1098
PRRX1 paired related homeobox 1 -2.10585
CTSG cathepsin G -2.1003
BCAP29 B-cell receptor-associated protein 29 -2.09735
A2M alpha-2-macroglobulin -2.08135
MOB4 MOB family member 4, phocein -2.0795
KIF2A kinesin heavy chain member 2A -2.06968
SINHCAF SIN3-HDAC complex associated factor -2.06795
AGPS alkylglycerone phosphate synthase -2.05615
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.0255
NEO1 neogenin 1 -2.0031