| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | diphenyl-p-phenylenediamine 4.98 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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84 genes differentially expressed following the CRCGN008_HEPG2_24H:E16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 9.93975 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 5.11585 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 5.09655 |
| CHMP6 | charged multivesicular body protein 6 | 4.93695 |
| MAMLD1 | mastermind-like domain containing 1 | 4.9248 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 4.9194 |
| CDCA4 | cell division cycle associated 4 | 4.6651 |
| EGF | epidermal growth factor | 4.2874 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 4.18682 |
| GPER1 | G protein-coupled estrogen receptor 1 | 4.10313 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.52445 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 3.23743 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.94623 |
| PCDHB11 | protocadherin beta 11 | 2.8999 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.84465 |
| CCNF | cyclin F | 2.54488 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 2.51075 |
| APOM | apolipoprotein M | 2.4996 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.4749 |
| MDN1 | MDN1, midasin homolog (yeast) | 2.40355 |
| CCDC85B | coiled-coil domain containing 85B | 2.3581 |
| THOP1 | thimet oligopeptidase 1 | 2.28405 |
| PBK | PDZ binding kinase | 2.26535 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 2.26225 |
| MTPAP | mitochondrial poly(A) polymerase | 2.23105 |
| ZNF593 | zinc finger protein 593 | 2.21395 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 2.1943 |
| CLCC1 | chloride channel CLIC-like 1 | 2.1906 |
| EPHA3 | EPH receptor A3 | 2.17825 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.14495 |
| ST20-MTHFS | ST20-MTHFS readthrough | 2.14025 |
| ABT1 | activator of basal transcription 1 | 2.1353 |
| SCML2 | sex comb on midleg-like 2 (Drosophila) | 2.115 |
| HDHD5 | haloacid dehalogenase like hydrolase domain containing 5 | 2.1098 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | 2.09065 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 2.0851 |
| HOOK3 | hook microtubule-tethering protein 3 | 2.04565 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | 2.035 |
| C1QL1 | complement component 1, q subcomponent-like 1 | 2.0185 |
| HSPA14 | heat shock 70kDa protein 14 | 2.00125 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -10.0 |
| VAT1 | vesicle amine transport 1 | -10.0 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -5.84205 |
| KDM3A | lysine (K)-specific demethylase 3A | -5.55325 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -5.0152 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -5.0 |
| PCNA | proliferating cell nuclear antigen | -5.0 |
| GOLT1B | golgi transport 1B | -4.98355 |
| SLC35F2 | solute carrier family 35, member F2 | -4.64805 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.2456 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -4.0819 |
| ANKRD10 | ankyrin repeat domain 10 | -3.57595 |
| GNAS | GNAS complex locus | -3.24139 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.05865 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.98265 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.87385 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -2.69932 |
| CD58 | CD58 molecule | -2.60397 |
| VLDLR | very low density lipoprotein receptor | -2.5678 |
| AEBP1 | AE binding protein 1 | -2.5193 |
| RBM34 | RNA binding motif protein 34 | -2.46362 |
| RSF1 | remodeling and spacing factor 1 | -2.4541 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -2.3999 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.38683 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.3753 |
| FTSJ3 | FtsJ homolog 3 (E. coli) | -2.31935 |
| TXNDC9 | thioredoxin domain containing 9 | -2.27913 |
| RECQL | RecQ helicase-like | -2.2752 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -2.25965 |
| IRAK4 | interleukin-1 receptor-associated kinase 4 | -2.25495 |
| RARS1 | arginyl-tRNA synthetase 1 | -2.24745 |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 | -2.21415 |
| RBM6 | RNA binding motif protein 6 | -2.1717 |
| GABPA | GA binding protein transcription factor, alpha subunit 60kDa | -2.16665 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.12895 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -2.11777 |
| SYNJ1 | synaptojanin 1 | -2.08512 |
| RINT1 | RAD50 interactor 1 | -2.07435 |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | -2.0674 |
| THBS2 | thrombospondin 2 | -2.0546 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.04965 |
| EXOC1 | exocyst complex component 1 | -2.0296 |
| LDHA | lactate dehydrogenase A | -2.0283 |
| NLK | nemo-like kinase | -2.0153 |
