CRCGN008_HEPG2_24H:E17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenyl-p-phenylenediamine 2.49 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN008_HEPG2_24H:E17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 10.0
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.85615
PRR15L proline rich 15-like 4.54425
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.35235
CHN1 chimerin 1 4.2655
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.55515
SFTPB surfactant protein B 3.4088
CYCS cytochrome c, somatic 3.3504
GPER1 G protein-coupled estrogen receptor 1 3.3106
TIAM1 T-cell lymphoma invasion and metastasis 1 3.2157
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.19998
VGLL4 vestigial-like family member 4 2.93283
SIRT3 sirtuin 3 2.89137
TLR4 toll-like receptor 4 2.57795
NPAT nuclear protein, ataxia-telangiectasia locus 2.18753
NMU neuromedin U 2.15875
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.1571
FOS FBJ murine osteosarcoma viral oncogene homolog 2.1564
PCOLCE procollagen C-endopeptidase enhancer 2.1272
LY9 lymphocyte antigen 9 2.08582
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.0748
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 2.0722
WDTC1 WD and tetratricopeptide repeats 1 2.04528

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -5.74315
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0711
DNM1L dynamin 1-like -5.05295
NRIP1 nuclear receptor interacting protein 1 -4.76975
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.7543
CCNB2 cyclin B2 -4.6831
TLCD3A TLC domain containing 3A -4.58695
FASTKD5 FAST kinase domains 5 -4.37065
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -4.21393
INSIG1 insulin induced gene 1 -3.71282
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.63425
PRPF4 pre-mRNA processing factor 4 -3.3957
OXA1L oxidase (cytochrome c) assembly 1-like -3.2405
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.99365
RNF167 ring finger protein 167 -2.90285
MAP7 microtubule-associated protein 7 -2.86785
FHL2 four and a half LIM domains 2 -2.7359
SNX11 sorting nexin 11 -2.42097
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.2706
TMEM165 transmembrane protein 165 -2.1589
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.14775
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -2.13355
WASHC4 WASH complex subunit 4 -2.12832
TSPAN12 tetraspanin 12 -2.1221
CTBP2 C-terminal binding protein 2 -2.07255