CRCGN008_HEPG2_24H:E19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethylstilbestrol 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

488 genes differentially expressed following the CRCGN008_HEPG2_24H:E19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 7.73785
TIMP2 TIMP metallopeptidase inhibitor 2 7.52215
SQOR sulfide quinone oxidoreductase 7.1455
INPP1 inositol polyphosphate-1-phosphatase 6.7032
NPDC1 neural proliferation, differentiation and control, 1 6.6495
TRIB3 tribbles pseudokinase 3 6.4243
TXNRD1 thioredoxin reductase 1 6.15395
KIFBP kinesin family binding protein 5.94235
NOTCH1 notch 1 5.58245
RPL39L ribosomal protein L39-like 5.2959
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 5.2588
BZW2 basic leucine zipper and W2 domains 2 5.23265
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.17435
CBR1 carbonyl reductase 1 4.98065
CYCS cytochrome c, somatic 4.8547
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.8419
VAT1 vesicle amine transport 1 4.8251
MVP major vault protein 4.81615
NANOS3 nanos homolog 3 (Drosophila) 4.78225
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.7607
EGR1 early growth response 1 4.62085
CCP110 centriolar coiled coil protein 110kDa 4.6122
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 4.5869
SQSTM1 sequestosome 1 4.56503
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 4.53765
PRKCH protein kinase C, eta 4.43328
CDPF1 cysteine-rich, DPF motif domain containing 1 4.42265
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.3824
CHN1 chimerin 1 4.2432
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.2219
ACOT9 acyl-CoA thioesterase 9 4.14885
FOSL1 FOS-like antigen 1 4.0618
SMAD3 SMAD family member 3 3.98316
ZFP36 ZFP36 ring finger protein 3.9366
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 3.9211
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.8981
LCN2 lipocalin 2 3.73025
GPER1 G protein-coupled estrogen receptor 1 3.7212
TOMM34 translocase of outer mitochondrial membrane 34 3.6074
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.5746
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.49572
IER3 immediate early response 3 3.45775
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 3.45435
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.44315
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.44305
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.3821
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.35945
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.34905
JADE2 jade family PHD finger 2 3.20567
ZMYM2 zinc finger, MYM-type 2 3.16717
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.16315
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 3.16025
DYNLT3 dynein, light chain, Tctex-type 3 3.1498
TRIB1 tribbles pseudokinase 1 3.10965
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.00672
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.9509
H2BC12 H2B clustered histone 12 2.94597
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.92338
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.9013
RALB v-ral simian leukemia viral oncogene homolog B 2.89792
NARS1 asparaginyl-tRNA synthetase 1 2.88985
ASCC3 activating signal cointegrator 1 complex subunit 3 2.8877
STX4 syntaxin 4 2.88425
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.8726
MRPS18B mitochondrial ribosomal protein S18B 2.85313
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.80665
DUSP6 dual specificity phosphatase 6 2.78972
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.7829
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.78195
C2CD2 C2 calcium-dependent domain containing 2 2.7771
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2.75345
ABHD4 abhydrolase domain containing 4 2.7096
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.6939
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.6882
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.67745
CARS1 cysteinyl-tRNA synthetase 1 2.6769
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.6746
PIBF1 progesterone immunomodulatory binding factor 1 2.67405
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.66808
CASP8 caspase 8, apoptosis-related cysteine peptidase 2.66052
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 2.6476
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.6461
GLRX glutaredoxin (thioltransferase) 2.62812
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.62122
OSBPL3 oxysterol binding protein-like 3 2.61595
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.61115
PLXND1 plexin D1 2.5934
MTMR6 myotubularin related protein 6 2.58415
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.5796
LOC128125814 uncharacterized LOC128125814 2.5749
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.5746
SLC75A1 solute carrier family 75 member 1 2.569
PRKCD protein kinase C, delta 2.54965
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.54615
TERF2IP telomeric repeat binding factor 2, interacting protein 2.54235
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.54218
CEP170 centrosomal protein 170kDa 2.54205
NFU1 NFU1 iron-sulfur cluster scaffold 2.5391
SARS1 seryl-tRNA synthetase 1 2.5387
NME8 NME/NM23 family member 8 2.5374
USP8 ubiquitin specific peptidase 8 2.53625
OXCT2 3-oxoacid CoA transferase 2 2.53305
TRIM8 tripartite motif containing 8 2.53155
PLK3 polo-like kinase 3 2.52645
ADSS2 adenylosuccinate synthase 2 2.522
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.5201
MMRN2 multimerin 2 2.51355
ADAM17 ADAM metallopeptidase domain 17 2.51212
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.51
BMS1 BMS1 ribosome biogenesis factor 2.5092
GADD45A growth arrest and DNA-damage-inducible, alpha 2.4981
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.4939
NBAS neuroblastoma amplified sequence 2.47395
LRRC8D leucine rich repeat containing 8 family, member D 2.4671
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2.4666
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.46575
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.4648
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.45967
CTC1 CTS telomere maintenance complex component 1 2.44905
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.43425
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.41355
ERCC3 excision repair cross-complementation group 3 2.39055
EMCN endomucin 2.3884
ELP3 elongator acetyltransferase complex subunit 3 2.3822
WDR12 WD repeat domain 12 2.3782
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.3776
MRPL57 mitochondrial ribosomal protein L57 2.37152
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.36805
RPF1 ribosome production factor 1 homolog (S. cerevisiae) 2.35595
TASL TLR adaptor interacting with endolysosomal SLC15A4 2.3539
IFI6 interferon, alpha-inducible protein 6 2.3536
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 2.35305
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.3525
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 2.34585
CORO7-PAM16 CORO7-PAM16 readthrough 2.3458
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.34195
KLHL21 kelch-like family member 21 2.3357
UGDH UDP-glucose 6-dehydrogenase 2.33485
PNKP polynucleotide kinase 3'-phosphatase 2.33425
UPP1 uridine phosphorylase 1 2.33405
PRKCQ protein kinase C, theta 2.32212
KDR kinase insert domain receptor 2.30975
LRRK1 leucine-rich repeat kinase 1 2.3058
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.3018
STX6 syntaxin 6 2.29953
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough 2.29905
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.29595
PLPPR4 phospholipid phosphatase related 4 2.29405
IL4R interleukin 4 receptor 2.2867
SLC38A12 solute carrier family 38 member 12 2.28185
GJA4 gap junction protein, alpha 4, 37kDa 2.2738
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 2.271
MSLN mesothelin 2.26565
NPC1 Niemann-Pick disease, type C1 2.26428
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.25675
OXLD1 oxidoreductase-like domain containing 1 2.25453
PIWIL2 piwi-like RNA-mediated gene silencing 2 2.2537
ZZZ3 zinc finger, ZZ-type containing 3 2.25105
SFTPB surfactant protein B 2.24065
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 2.2401
STBD1 starch binding domain 1 2.2361
MTX1 metaxin 1 2.23505
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.23435
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2.22613
CAMTA2 calmodulin binding transcription activator 2 2.22595
TMEM140 transmembrane protein 140 2.21735
KDM6B lysine (K)-specific demethylase 6B 2.21103
MNT MAX network transcriptional repressor 2.21
TMEM204 transmembrane protein 204 2.2098
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.2086
PECAM1 platelet/endothelial cell adhesion molecule 1 2.20733
CCDC57 coiled-coil domain containing 57 2.1984
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.19485
TES testin LIM domain protein 2.18745
GPN2 GPN-loop GTPase 2 2.18605
TRIM13 tripartite motif containing 13 2.18185
HPSE heparanase 2.1725
LAP3 leucine aminopeptidase 3 2.1695
MAPK13 mitogen-activated protein kinase 13 2.16813
DDIT4 DNA-damage-inducible transcript 4 2.1653
FOS FBJ murine osteosarcoma viral oncogene homolog 2.1597
OARD1 O-acyl-ADP-ribose deacylase 1 2.1583
EFHC1 EF-hand domain (C-terminal) containing 1 2.158
CCNJ cyclin J 2.1557
S1PR1 sphingosine-1-phosphate receptor 1 2.15515
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 2.15435
AMOTL2 angiomotin like 2 2.1534
DCTN1 dynactin 1 2.14855
HABP2 hyaluronan binding protein 2 2.14785
NUPR1 nuclear protein, transcriptional regulator, 1 2.142
TPP2 tripeptidyl peptidase II 2.14047
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 2.1395
BCL10 B-cell CLL/lymphoma 10 2.13915
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.13905
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.13615
PPL periplakin 2.1337
STX1A syntaxin 1A (brain) 2.1269
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.1177
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 2.1162
SCN1B sodium channel, voltage gated, type I beta subunit 2.11605
LGSN lengsin, lens protein with glutamine synthetase domain 2.11345
VWF von Willebrand factor 2.09955
IFI44 interferon-induced protein 44 2.0985
RBKS ribokinase 2.09648
ARHGAP10 Rho GTPase activating protein 10 2.09545
YARS1 tyrosyl-tRNA synthetase 1 2.09325
TRIM5 tripartite motif containing 5 2.0901
VGLL4 vestigial-like family member 4 2.08425
EVI2A ecotropic viral integration site 2A 2.0802
GARRE1 granule associated Rac and RHOG effector 1 2.07995
FASTKD5 FAST kinase domains 5 2.0768
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.07385
CSNK1G1 casein kinase 1, gamma 1 2.06538
GSDMB gasdermin B 2.0631
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.05935
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.058
ADGRF5 adhesion G protein-coupled receptor F5 2.05665
SKIC2 SKI2 subunit of superkiller complex 2.0559
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 2.05385
FOXC2 forkhead box C2 2.05065
SOX4 SRY (sex determining region Y)-box 4 2.04639
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.04525
WDR45B WD repeat domain 45B 2.0424
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2.04173
PDGFA platelet-derived growth factor alpha polypeptide 2.04113
EPAS1 endothelial PAS domain protein 1 2.04078
TAPT1 transmembrane anterior posterior transformation 1 2.03915
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.03685
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 2.03675
LEPROTL1 leptin receptor overlapping transcript-like 1 2.0322
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.03032
RGS3 regulator of G-protein signaling 3 2.0291
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 2.0289
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 2.0265
TUBB6 tubulin, beta 6 class V 2.0261
AARS1 alanyl-tRNA synthetase 1 2.02585
GRAMD4 GRAM domain containing 4 2.02415
PHTF1 putative homeodomain transcription factor 1 2.01993
HEATR6 HEAT repeat containing 6 2.01805
SH3BP4 SH3-domain binding protein 4 2.01635
SMIM40 small integral membrane protein 40 2.0162
FAM124B family with sequence similarity 124B 2.01285
PSPC1 paraspeckle component 1 2.01255
ISG15 ISG15 ubiquitin-like modifier 2.0123
CRX cone-rod homeobox 2.01175
F2R coagulation factor II (thrombin) receptor 2.0092
BYSL bystin-like 2.0085
BGN biglycan 2.00797
BABAM2 BRISC and BRCA1 A complex member 2 2.0072
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.0069
FBXO7 F-box protein 7 2.00505
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.0005

decreased expression

Symbol Name Standardized Value
MELK maternal embryonic leucine zipper kinase -9.03935
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -7.1337
ICAM3 intercellular adhesion molecule 3 -6.9485
PCNA proliferating cell nuclear antigen -6.86115
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.72335
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -6.4881
DCK deoxycytidine kinase -6.35055
B4GAT1 beta-1,4-glucuronyltransferase 1 -6.2977
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -6.2526
CDK1 cyclin-dependent kinase 1 -6.23285
CD320 CD320 molecule -6.21285
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -6.11322
HADH hydroxyacyl-CoA dehydrogenase -6.10572
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -6.01988
TOP2A topoisomerase (DNA) II alpha 170kDa -5.9818
UBE2C ubiquitin-conjugating enzyme E2C -5.87505
TCTN1 tectonic family member 1 -5.779
ISOC1 isochorismatase domain containing 1 -5.75245
ADI1 acireductone dioxygenase 1 -5.70935
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -5.67085
CDC25B cell division cycle 25B -5.5525
MRPS2 mitochondrial ribosomal protein S2 -5.494
CCNB1 cyclin B1 -5.4575
PLK1 polo-like kinase 1 -5.3979
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.30745
ALDOC aldolase C, fructose-bisphosphate -5.26705
FGFR4 fibroblast growth factor receptor 4 -5.23
CDC20 cell division cycle 20 -5.1265
CCNA2 cyclin A2 -5.1026
LDHD lactate dehydrogenase D -5.1004
AURKB aurora kinase B -4.93015
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -4.82325
SH3D19 SH3 domain containing 19 -4.62488
STMN1 stathmin 1 -4.5914
GOLT1B golgi transport 1B -4.5494
SOAT2 sterol O-acyltransferase 2 -4.50625
MAP7 microtubule-associated protein 7 -4.43433
PSRC1 proline/serine-rich coiled-coil 1 -4.33105
DNM1L dynamin 1-like -4.3103
BIRC5 baculoviral IAP repeat containing 5 -4.2933
HSPB1 heat shock 27kDa protein 1 -4.22085
TMEM109 transmembrane protein 109 -4.2191
TMEM97 transmembrane protein 97 -4.17938
AZGP1 alpha-2-glycoprotein 1, zinc-binding -4.06318
GNAS GNAS complex locus -4.05705
ZW10 zw10 kinetochore protein -3.91305
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.89125
DSG2 desmoglein 2 -3.8531
TOMM70 translocase of outer mitochondrial membrane 70 -3.7093
C5 complement component 5 -3.63945
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.63785
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.5311
KIF11 kinesin family member 11 -3.4894
CLIC4 chloride intracellular channel 4 -3.48322
ASF1B anti-silencing function 1B histone chaperone -3.4734
HSPA8 heat shock 70kDa protein 8 -3.3358
PGM1 phosphoglucomutase 1 -3.29275
TSPAN6 tetraspanin 6 -3.27813
CHEK2 checkpoint kinase 2 -3.21975
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -3.2114
IDI1 isopentenyl-diphosphate delta isomerase 1 -3.2102
DSCC1 DNA replication and sister chromatid cohesion 1 -3.16545
PGAM4 phosphoglycerate mutase family member 4 -3.1436
CCNF cyclin F -3.12762
HMG20B high mobility group 20B -3.12407
TCERG1 transcription elongation regulator 1 -3.0883
HNRNPM heterogeneous nuclear ribonucleoprotein M -3.0792
DERA deoxyribose-phosphate aldolase (putative) -3.07165
NT5DC2 5'-nucleotidase domain containing 2 -3.0392
PDZD2 PDZ domain containing 2 -3.038
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -3.02365
ZNF586 zinc finger protein 586 -3.02165
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.97005
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.9541
ACAA1 acetyl-CoA acyltransferase 1 -2.95205
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.95068
CDCA4 cell division cycle associated 4 -2.9505
HMGA2 high mobility group AT-hook 2 -2.94125
H2AX H2A.X variant histone -2.9312
PECR peroxisomal trans-2-enoyl-CoA reductase -2.91285
UBE2S ubiquitin-conjugating enzyme E2S -2.91135
AURKA aurora kinase A -2.90887
RECQL RecQ helicase-like -2.8877
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.8806
TFDP1 transcription factor Dp-1 -2.8588
DHFR dihydrofolate reductase -2.85209
UBL5 ubiquitin-like 5 -2.84735
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.8417
NUP85 nucleoporin 85kDa -2.83815
DCP2 decapping mRNA 2 -2.82505
CDK4 cyclin-dependent kinase 4 -2.8194
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.80595
PRUNE1 prune exopolyphosphatase 1 -2.80553
SOSTDC1 sclerostin domain containing 1 -2.80355
MED21 mediator complex subunit 21 -2.79415
RNASE4 ribonuclease, RNase A family, 4 -2.77025
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.74257
DHCR7 7-dehydrocholesterol reductase -2.73925
MSMO1 methylsterol monooxygenase 1 -2.7213
CDCA8 cell division cycle associated 8 -2.7208
NFIL3 nuclear factor, interleukin 3 regulated -2.7196
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.71945
TROAP trophinin associated protein -2.70595
FBXO5 F-box protein 5 -2.69795
TUBB2A tubulin, beta 2A class IIa -2.69313
PAIP2B poly(A) binding protein interacting protein 2B -2.672
FBXL12 F-box and leucine-rich repeat protein 12 -2.66915
FEN1 flap structure-specific endonuclease 1 -2.66855
TUBA3E tubulin, alpha 3e -2.6604
LBR lamin B receptor -2.6587
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 -2.65705
MIS18A MIS18 kinetochore protein A -2.63375
TUBB4B tubulin, beta 4B class IVb -2.62368
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.62185
TBC1D10C TBC1 domain family, member 10C -2.6136
CCNE1 cyclin E1 -2.6098
S100A4 S100 calcium binding protein A4 -2.60805
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.608
AHCY adenosylhomocysteinase -2.6039
PRCP prolylcarboxypeptidase (angiotensinase C) -2.59225
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.58775
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.5818
CCKBR cholecystokinin B receptor -2.56095
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.5541
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha -2.5465
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.5454
ANKRD46 ankyrin repeat domain 46 -2.54175
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.5301
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.52995
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.5262
FBXO3 F-box protein 3 -2.5144
SIAH2 siah E3 ubiquitin protein ligase 2 -2.50435
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -2.4913
KIF15 kinesin family member 15 -2.48775
GPC3 glypican 3 -2.48125
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -2.47347
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.45965
ZMIZ1 zinc finger, MIZ-type containing 1 -2.43975
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.43942
FZD7 frizzled class receptor 7 -2.43342
DONSON downstream neighbor of SON -2.41145
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -2.40205
RACGAP1 Rac GTPase activating protein 1 -2.399
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.39163
DDB2 damage-specific DNA binding protein 2, 48kDa -2.38985
CCNG1 cyclin G1 -2.3821
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.37195
RAI14 retinoic acid induced 14 -2.3643
ZNF43 zinc finger protein 43 -2.3621
MCM10 minichromosome maintenance complex component 10 -2.34935
SCAND1 SCAN domain containing 1 -2.34215
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -2.33235
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.32725
SIPA1L1 signal-induced proliferation-associated 1 like 1 -2.32223
HAT1 histone acetyltransferase 1 -2.3178
UNG uracil-DNA glycosylase -2.31535
PRPF4 pre-mRNA processing factor 4 -2.31212
DYNLL1 dynein, light chain, LC8-type 1 -2.30695
NNT nicotinamide nucleotide transhydrogenase -2.30682
GPN3 GPN-loop GTPase 3 -2.30405
RPIA ribose 5-phosphate isomerase A -2.29395
RAN RAN, member RAS oncogene family -2.28938
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.2882
TMEM106C transmembrane protein 106C -2.27935
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.2792
TDG thymine-DNA glycosylase -2.2622
ZDHHC6 zinc finger, DHHC-type containing 6 -2.26085
ZNF248 zinc finger protein 248 -2.2602
UBE2A ubiquitin-conjugating enzyme E2A -2.258
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.25185
TRMT5 tRNA methyltransferase 5 -2.25185
GPC4 glypican 4 -2.24577
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -2.24225
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.233
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.2327
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.23095
SRSF3 serine/arginine-rich splicing factor 3 -2.20482
MTA1 metastasis associated 1 -2.2023
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 -2.19585
NPPB natriuretic peptide B -2.19275
RFC4 replication factor C (activator 1) 4, 37kDa -2.1924
LYZ lysozyme -2.18165
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.18145
H2AZ1 H2A.Z variant histone 1 -2.17658
CHL1 cell adhesion molecule L1-like -2.1688
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.16435
ELP5 elongator acetyltransferase complex subunit 5 -2.16275
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.15965
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.15545
EPHA7 EPH receptor A7 -2.1517
PPIF peptidylprolyl isomerase F -2.14695
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.14315
SCGB2A2 secretoglobin, family 2A, member 2 -2.1427
KIFC1 kinesin family member C1 -2.13835
TYK2 tyrosine kinase 2 -2.13795
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.13735
SEC13 SEC13 homolog (S. cerevisiae) -2.1365
AMDHD2 amidohydrolase domain containing 2 -2.1361
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.1304
ARHGAP19 Rho GTPase activating protein 19 -2.12725
TPX2 TPX2, microtubule-associated -2.127
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.12275
SPDL1 spindle apparatus coiled-coil protein 1 -2.1193
NELFCD negative elongation factor complex member C/D -2.1167
UBAC1 UBA domain containing 1 -2.1141
GLRX5 glutaredoxin 5 -2.1135
UBE2N ubiquitin-conjugating enzyme E2N -2.11225
NCAPD2 non-SMC condensin I complex, subunit D2 -2.10745
RPS5 ribosomal protein S5 -2.0952
CLCN2 chloride channel, voltage-sensitive 2 -2.09485
ZNF559-ZNF177 ZNF559-ZNF177 readthrough -2.09225
SRSF2 serine/arginine-rich splicing factor 2 -2.08533
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.08125
PCCA propionyl CoA carboxylase, alpha polypeptide -2.08125
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.06465
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.0643
KIF18B kinesin family member 18B -2.0596
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -2.05638
CDK2 cyclin-dependent kinase 2 -2.05578
PNRC2 proline-rich nuclear receptor coactivator 2 -2.05195
TCL1A T-cell leukemia/lymphoma 1A -2.05078
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.0438
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.03585
KANK1 KN motif and ankyrin repeat domains 1 -2.03205
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.02863
GRAMD1B GRAM domain containing 1B -2.02675
RABL6 RAB, member RAS oncogene family-like 6 -2.02495
TESK2 testis-specific kinase 2 -2.0248
HDAC3 histone deacetylase 3 -2.02325
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.0196
TUBB2B tubulin, beta 2B class IIb -2.0138
GAMT guanidinoacetate N-methyltransferase -2.011
TRIP13 thyroid hormone receptor interactor 13 -2.0092
USF2 upstream transcription factor 2, c-fos interacting -2.00557
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.005
LEFTY1 left-right determination factor 1 -2.0