CRCGN008_HEPG2_24H:E20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethylstilbestrol 19.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

115 genes differentially expressed following the CRCGN008_HEPG2_24H:E20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
CHN1 chimerin 1 6.46495
BZW2 basic leucine zipper and W2 domains 2 6.0323
CNPY3 canopy FGF signaling regulator 3 5.41535
UBQLN2 ubiquilin 2 5.1579
ASCC3 activating signal cointegrator 1 complex subunit 3 5.0587
AMDHD2 amidohydrolase domain containing 2 4.6179
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.3768
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.0549
PRR15L proline rich 15-like 3.98825
H2BC12 H2B clustered histone 12 3.66765
INPP1 inositol polyphosphate-1-phosphatase 3.50835
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.45685
CDC45 cell division cycle 45 3.0216
TIMP2 TIMP metallopeptidase inhibitor 2 3.01585
CCNH cyclin H 2.97005
PMM2 phosphomannomutase 2 2.90355
MCM3 minichromosome maintenance complex component 3 2.8758
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.8698
SFTPB surfactant protein B 2.73522
KIFBP kinesin family binding protein 2.6876
CCP110 centriolar coiled coil protein 110kDa 2.6529
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.64325
TRIB1 tribbles pseudokinase 1 2.53595
GPATCH8 G patch domain containing 8 2.529
RBM15B RNA binding motif protein 15B 2.5121
CCDC85B coiled-coil domain containing 85B 2.47455
SQSTM1 sequestosome 1 2.38217
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.3677
MVP major vault protein 2.3117
TOMM34 translocase of outer mitochondrial membrane 34 2.29795
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.2894
CNIH4 cornichon family AMPA receptor auxiliary protein 4 2.26985
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2.23615
PAK1IP1 PAK1 interacting protein 1 2.22655
YIPF3 Yip1 domain family, member 3 2.18475
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.1672
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.15307
BCAS2 breast carcinoma amplified sequence 2 2.14815
MMUT methylmalonyl-CoA mutase 2.14517
VGLL4 vestigial-like family member 4 2.10862
KIF20A kinesin family member 20A 2.0934
ATP8B4 ATPase, class I, type 8B, member 4 2.09085
ZMYM2 zinc finger, MYM-type 2 2.07772
CTSD cathepsin D 2.0657
STN1 STN1 subunit of CST complex 2.0555
PHF20L1 PHD finger protein 20-like 1 2.0507
NUCB2 nucleobindin 2 2.0502
METTL22 methyltransferase like 22 2.02605
CTPS1 CTP synthase 1 2.0023
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.0009

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.8544
OXA1L oxidase (cytochrome c) assembly 1-like -5.5761
CDC25B cell division cycle 25B -5.46665
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.33475
MELK maternal embryonic leucine zipper kinase -5.3238
LDHD lactate dehydrogenase D -4.9719
ANKRD10 ankyrin repeat domain 10 -4.8875
CDK1 cyclin-dependent kinase 1 -4.81855
DCK deoxycytidine kinase -4.76505
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.7031
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.4725
FGFR4 fibroblast growth factor receptor 4 -4.4058
CCNB2 cyclin B2 -4.2217
LAP3 leucine aminopeptidase 3 -4.2146
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.11625
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.94012
DERA deoxyribose-phosphate aldolase (putative) -3.8697
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.8655
PLK1 polo-like kinase 1 -3.697
ZW10 zw10 kinetochore protein -3.4752
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.46065
ZMIZ1 zinc finger, MIZ-type containing 1 -3.43515
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -3.3965
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.2269
EFHD2 EF-hand domain family, member D2 -3.2174
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.13815
ALDOC aldolase C, fructose-bisphosphate -3.1199
TOP2A topoisomerase (DNA) II alpha 170kDa -3.09315
LGMN legumain -3.06965
COPS7A COP9 signalosome subunit 7A -3.0351
TCTN1 tectonic family member 1 -3.01715
MAP7 microtubule-associated protein 7 -2.97172
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.9315
ACAA1 acetyl-CoA acyltransferase 1 -2.8924
AURKB aurora kinase B -2.8843
HADH hydroxyacyl-CoA dehydrogenase -2.75918
UBE2C ubiquitin-conjugating enzyme E2C -2.7324
SOAT2 sterol O-acyltransferase 2 -2.71185
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.53545
SH3D19 SH3 domain containing 19 -2.5285
CCNF cyclin F -2.45817
SOX9 SRY (sex determining region Y)-box 9 -2.44225
RNF167 ring finger protein 167 -2.37855
CLIC4 chloride intracellular channel 4 -2.28493
MVD mevalonate (diphospho) decarboxylase -2.2691
BIRC5 baculoviral IAP repeat containing 5 -2.26013
CCNA2 cyclin A2 -2.25478
CLSTN3 calsyntenin 3 -2.2517
ISLR immunoglobulin superfamily containing leucine-rich repeat -2.2483
PVRIG poliovirus receptor related immunoglobulin domain containing -2.19555
PBK PDZ binding kinase -2.1582
PROS1 protein S (alpha) -2.15315
SPAG6 sperm associated antigen 6 -2.14193
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.1332
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 -2.12927
CCDC170 coiled-coil domain containing 170 -2.1273
RHOH ras homolog family member H -2.1117
SORD sorbitol dehydrogenase -2.11055
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.1093
TTC12 tetratricopeptide repeat domain 12 -2.0793
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -2.0603
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.05755
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.05385
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -2.02875