CRCGN008_HEPG2_24H:E21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethylstilbestrol 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

147 genes differentially expressed following the CRCGN008_HEPG2_24H:E21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.4965
BACE2 beta-site APP-cleaving enzyme 2 5.54285
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.18065
CHMP6 charged multivesicular body protein 6 4.8684
EGF epidermal growth factor 4.8382
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.61535
MSRA methionine sulfoxide reductase A 4.38645
SLC75A1 solute carrier family 75 member 1 4.29065
MAMLD1 mastermind-like domain containing 1 4.08775
GPER1 G protein-coupled estrogen receptor 1 4.02878
CD40 CD40 molecule, TNF receptor superfamily member 5 3.98727
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.9344
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.4621
TIAM1 T-cell lymphoma invasion and metastasis 1 3.19322
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.15712
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.1278
CHN1 chimerin 1 3.0134
CRTAP cartilage associated protein 3.01095
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.9905
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.9879
LYRM1 LYR motif containing 1 2.9715
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.91245
CNPY3 canopy FGF signaling regulator 3 2.90935
MAP7 microtubule-associated protein 7 2.83645
RBMS3 RNA binding motif, single stranded interacting protein 3 2.80295
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.76825
RPN1 ribophorin I 2.7004
FEV FEV (ETS oncogene family) 2.63725
RAP1GAP RAP1 GTPase activating protein 2.63715
ANO1 anoctamin 1, calcium activated chloride channel 2.59275
ZNF589 zinc finger protein 589 2.55168
CCNH cyclin H 2.48125
NUP93 nucleoporin 93kDa 2.4645
TERF2IP telomeric repeat binding factor 2, interacting protein 2.4471
GAA glucosidase, alpha; acid 2.44275
BPHL biphenyl hydrolase-like (serine hydrolase) 2.4243
COX5A cytochrome c oxidase subunit Va 2.4204
MMUT methylmalonyl-CoA mutase 2.4169
TRDMT1 tRNA aspartic acid methyltransferase 1 2.40045
PHOX2B paired-like homeobox 2b 2.3895
MCM3 minichromosome maintenance complex component 3 2.31975
CLEC1A C-type lectin domain family 1, member A 2.3085
PMM2 phosphomannomutase 2 2.30405
CCNF cyclin F 2.29387
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.29005
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.28785
CYB5R2 cytochrome b5 reductase 2 2.28055
OTOR otoraplin 2.26415
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.26345
SLC35H1 solute carrier family 35 member H1 2.2569
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.24705
CCP110 centriolar coiled coil protein 110kDa 2.23285
EBNA1BP2 EBNA1 binding protein 2 2.22215
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.21595
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.19508
PHAF1 phagosome assembly factor 1 2.1824
LTA lymphotoxin alpha 2.17835
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 2.164
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.15995
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.15365
RASL11B RAS-like, family 11, member B 2.15
ELAC2 elaC ribonuclease Z 2 2.14385
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.14345
DCSTAMP dendrocyte expressed seven transmembrane protein 2.1401
ZFP36 ZFP36 ring finger protein 2.1346
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.12945
ADGRF5 adhesion G protein-coupled receptor F5 2.12243
TERT telomerase reverse transcriptase 2.1182
LAMP5 lysosomal-associated membrane protein family, member 5 2.11265
ALDOB aldolase B, fructose-bisphosphate 2.11065
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 2.1063
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.1009
MED4 mediator complex subunit 4 2.0982
TMEM212 transmembrane protein 212 2.09635
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2.0926
TLR4 toll-like receptor 4 2.0889
GDAP2 ganglioside induced differentiation associated protein 2 2.08775
MAPK8 mitogen-activated protein kinase 8 2.08012
NUCB2 nucleobindin 2 2.0706
ASCC3 activating signal cointegrator 1 complex subunit 3 2.0691
DDB2 damage-specific DNA binding protein 2, 48kDa 2.0678
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.05785
SCD5 stearoyl-CoA desaturase 5 2.0575
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 2.0573
GOLGA6L9 golgin A6 family-like 9 2.03955
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 2.03925
USP53 ubiquitin specific peptidase 53 2.0341
SWAP70 SWAP switching B-cell complex 70kDa subunit 2.0201
PRODH2 proline dehydrogenase (oxidase) 2 2.01585
PLGLB2 plasminogen-like B2 2.01045
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.0082

decreased expression

Symbol Name Standardized Value
HSPB1 heat shock 27kDa protein 1 -5.56975
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.1472
ADI1 acireductone dioxygenase 1 -5.1073
CDC20 cell division cycle 20 -4.6933
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.6191
RBM15B RNA binding motif protein 15B -4.47465
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -4.2336
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.0343
FGFR4 fibroblast growth factor receptor 4 -4.01538
FAIM Fas apoptotic inhibitory molecule -4.0071
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.65465
CASC3 cancer susceptibility candidate 3 -3.6321
RPS5 ribosomal protein S5 -3.58945
FASTKD5 FAST kinase domains 5 -3.4842
CDC25B cell division cycle 25B -3.47295
BLCAP bladder cancer associated protein -3.39765
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.3501
SPAG4 sperm associated antigen 4 -3.24085
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.2073
TES testin LIM domain protein -3.17423
HSPA8 heat shock 70kDa protein 8 -3.15962
RNF167 ring finger protein 167 -3.00075
RSU1 Ras suppressor protein 1 -2.96165
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.71038
MELK maternal embryonic leucine zipper kinase -2.6957
BCR breakpoint cluster region -2.6727
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.66482
HDAC2 histone deacetylase 2 -2.55705
FAM168B family with sequence similarity 168, member B -2.51445
OXA1L oxidase (cytochrome c) assembly 1-like -2.5135
NRIP1 nuclear receptor interacting protein 1 -2.45167
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.39525
RBM15 RNA binding motif protein 15 -2.38708
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.36835
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.32305
SMG8 SMG8 nonsense mediated mRNA decay factor -2.25045
TOP2A topoisomerase (DNA) II alpha 170kDa -2.21693
TATDN2 TatD DNase domain containing 2 -2.20805
LRRC42 leucine rich repeat containing 42 -2.20545
CCDC92 coiled-coil domain containing 92 -2.1952
RNF11 ring finger protein 11 -2.185
AKAP8 A kinase (PRKA) anchor protein 8 -2.17327
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.17065
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.1606
TRIB3 tribbles pseudokinase 3 -2.1601
FAM8A1 family with sequence similarity 8, member A1 -2.1224
GTF2A2 general transcription factor IIA, 2, 12kDa -2.11085
SIRT7 sirtuin 7 -2.0976
TRAPPC3 trafficking protein particle complex 3 -2.09623
PDZD2 PDZ domain containing 2 -2.096
DNM1L dynamin 1-like -2.06215
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.04935
PMM1 phosphomannomutase 1 -2.0382
S100A9 S100 calcium binding protein A9 -2.03743
GH1 growth hormone 1 -2.03735
TCEA2 transcription elongation factor A (SII), 2 -2.0167