CRCGN008_HEPG2_24H:F01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-butyl chloride 40.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN008_HEPG2_24H:F01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 10.0
E2F2 E2F transcription factor 2 6.8311
CYCS cytochrome c, somatic 6.5885
RPL39L ribosomal protein L39-like 5.92405
ADRB2 adrenoceptor beta 2, surface 5.7572
CBR3 carbonyl reductase 3 5.5895
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.30455
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.26355
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.1403
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.07688
SSBP2 single-stranded DNA binding protein 2 4.0426
HOXA10 homeobox A10 3.73472
PRR15L proline rich 15-like 3.6789
PLSCR1 phospholipid scramblase 1 3.00565
UBE2J1 ubiquitin-conjugating enzyme E2, J1 2.93252
KDM5A lysine (K)-specific demethylase 5A 2.86437
EPHA3 EPH receptor A3 2.84988
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.80765
PRKCH protein kinase C, eta 2.7412
ZNF589 zinc finger protein 589 2.679
HOXC10 homeobox C10 2.60565
KIF20A kinesin family member 20A 2.5923
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.58988
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.55965
BCAS4 breast carcinoma amplified sequence 4 2.54105
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.43473
BACE2 beta-site APP-cleaving enzyme 2 2.4122
MAP7 microtubule-associated protein 7 2.33537
HLA-DRA major histocompatibility complex, class II, DR alpha 2.31337
RUNX3 runt-related transcription factor 3 2.28583
SCRN1 secernin 1 2.26705
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.25915
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.2472
GALK1 galactokinase 1 2.1898
CORO1A coronin, actin binding protein, 1A 2.13675
ZNF428 zinc finger protein 428 2.12705
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.098
TRAPPC13 trafficking protein particle complex 13 2.09535
MTERF3 mitochondrial transcription termination factor 3 2.08445
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.08345
KLRC4-KLRK1 KLRC4-KLRK1 readthrough 2.0758
WDR4 WD repeat domain 4 2.06635
ANAPC2 anaphase promoting complex subunit 2 2.0608
RAB32 RAB32, member RAS oncogene family 2.04135
BPY2B basic charge, Y-linked, 2B 2.0412
EVL Enah/Vasp-like 2.03705
IL12RB2 interleukin 12 receptor, beta 2 2.0314
CDK19 cyclin-dependent kinase 19 2.03085
LNPEP leucyl/cystinyl aminopeptidase 2.0059

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
LOC124907782 dual specificity protein phosphatase 22 -5.0384
TLCD3A TLC domain containing 3A -5.03465
CD320 CD320 molecule -4.7486
CCNB2 cyclin B2 -4.7139
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.6992
PCNA proliferating cell nuclear antigen -4.50795
SLC35F2 solute carrier family 35, member F2 -4.11425
FASTKD5 FAST kinase domains 5 -4.11115
RGS2 regulator of G-protein signaling 2 -3.69375
CD58 CD58 molecule -3.17903
OXA1L oxidase (cytochrome c) assembly 1-like -2.9036
FBXL12 F-box and leucine-rich repeat protein 12 -2.68945
NRIP1 nuclear receptor interacting protein 1 -2.67313
PGM1 phosphoglucomutase 1 -2.51315
ICAM3 intercellular adhesion molecule 3 -2.46625
CYFIP1 cytoplasmic FMR1 interacting protein 1 -2.448
NLRP4 NLR family, pyrin domain containing 4 -2.44195
WASHC4 WASH complex subunit 4 -2.41615
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.36925
TMEM230 transmembrane protein 230 -2.24165
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.1531
DDIT4 DNA-damage-inducible transcript 4 -2.1369
PRR7 proline rich 7 (synaptic) -2.07915
CDCP1 CUB domain containing protein 1 -2.06585
CAMTA2 calmodulin binding transcription activator 2 -2.02735
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.01945