CRCGN008_HEPG2_24H:F02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-butyl chloride 20.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN008_HEPG2_24H:F02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 7.15295
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 6.19273
ADRB2 adrenoceptor beta 2, surface 5.27585
STIMATE STIM activating enhancer 4.94485
CCL2 chemokine (C-C motif) ligand 2 4.83855
PRR15L proline rich 15-like 4.74985
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.18025
TXNL4B thioredoxin-like 4B 3.3706
RRAGA Ras-related GTP binding A 3.2519
TIAM1 T-cell lymphoma invasion and metastasis 1 3.21732
TBC1D31 TBC1 domain family, member 31 3.16935
CCNF cyclin F 3.14855
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.9328
EPHA3 EPH receptor A3 2.87263
RXYLT1 ribitol xylosyltransferase 1 2.7384
CYB561 cytochrome b561 2.73411
TSC22D3 TSC22 domain family, member 3 2.71738
BIRC2 baculoviral IAP repeat containing 2 2.50815
CDC45 cell division cycle 45 2.49795
KIF20A kinesin family member 20A 2.41815
FSD1 fibronectin type III and SPRY domain containing 1 2.35545
SOCS2 suppressor of cytokine signaling 2 2.33868
MAGEC2 melanoma antigen family C2 2.3087
DLK2 delta-like 2 homolog (Drosophila) 2.15415
AMBN ameloblastin (enamel matrix protein) 2.09675

decreased expression

Symbol Name Standardized Value
RPIA ribose 5-phosphate isomerase A -5.0
TLCD3A TLC domain containing 3A -4.7615
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.66275
LDHD lactate dehydrogenase D -4.48145
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -4.38425
CDC20 cell division cycle 20 -4.2605
CCNB2 cyclin B2 -3.93735
PRPF4 pre-mRNA processing factor 4 -3.8168
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.5488
FASTKD5 FAST kinase domains 5 -3.46785
GNAS GNAS complex locus -3.38679
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.96965
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.94148
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.8961
OXA1L oxidase (cytochrome c) assembly 1-like -2.79635
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.7049
CLK3 CDC-like kinase 3 -2.2067
XPA xeroderma pigmentosum, complementation group A -2.10485
CCNH cyclin H -2.09625