CRCGN008_HEPG2_24H:F08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN008_HEPG2_24H:F08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INTS3 integrator complex subunit 3 5.83405
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.7549
PPARG peroxisome proliferator-activated receptor gamma 4.4231
LCN2 lipocalin 2 4.0955
NPDC1 neural proliferation, differentiation and control, 1 4.0019
NMU neuromedin U 3.9085
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.80038
ANO1 anoctamin 1, calcium activated chloride channel 3.6969
EGF epidermal growth factor 3.65415
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.39115
MAP7 microtubule-associated protein 7 2.56093
EPHA3 EPH receptor A3 2.55125
APLNR apelin receptor 2.3262
ZNF589 zinc finger protein 589 2.15523
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.1429
SCRN1 secernin 1 2.1303
AK6 adenylate kinase 6 2.0345
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.0324
FSD1 fibronectin type III and SPRY domain containing 1 2.01095

decreased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.3129
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.17375
C2CD5 C2 calcium-dependent domain containing 5 -5.0
ADI1 acireductone dioxygenase 1 -4.81965
DSG2 desmoglein 2 -4.4757
HLA-DMA major histocompatibility complex, class II, DM alpha -4.109
OXA1L oxidase (cytochrome c) assembly 1-like -3.3204
SPAG4 sperm associated antigen 4 -3.3006
FASTKD5 FAST kinase domains 5 -3.1306
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.8688
TXNDC9 thioredoxin domain containing 9 -2.66668
SNX11 sorting nexin 11 -2.58765
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.58415
ICAM3 intercellular adhesion molecule 3 -2.4452
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.3081
ANKRD49 ankyrin repeat domain 49 -2.15825
RANBP2 RAN binding protein 2 -2.13233
MATN4 matrilin 4 -2.117
IP6K2 inositol hexakisphosphate kinase 2 -2.1076
RGS2 regulator of G-protein signaling 2 -2.09225
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -2.05355
CHPF chondroitin polymerizing factor -2.0277