CRCGN008_HEPG2_24H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

106 genes differentially expressed following the CRCGN008_HEPG2_24H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NMU neuromedin U 5.3542
MAMLD1 mastermind-like domain containing 1 4.74985
EPHB2 EPH receptor B2 4.73829
CCDC85B coiled-coil domain containing 85B 4.70835
BACE2 beta-site APP-cleaving enzyme 2 4.58615
E2F2 E2F transcription factor 2 4.3563
SSBP2 single-stranded DNA binding protein 2 4.20857
STXBP2 syntaxin binding protein 2 4.04035
GPER1 G protein-coupled estrogen receptor 1 3.85845
CCNF cyclin F 3.3733
DEFA6 defensin, alpha 6, Paneth cell-specific 3.21525
ABHD6 abhydrolase domain containing 6 3.21453
CCL2 chemokine (C-C motif) ligand 2 3.17275
REG1B regenerating islet-derived 1 beta 2.985
DEFA5 defensin, alpha 5, Paneth cell-specific 2.91595
BFSP2 beaded filament structural protein 2, phakinin 2.81985
HLA-DRA major histocompatibility complex, class II, DR alpha 2.74213
PRDM11 PR domain containing 11 2.67625
KLK1 kallikrein 1 2.6582
REG3A regenerating islet-derived 3 alpha 2.54675
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.5455
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.5338
SSX5 synovial sarcoma, X breakpoint 5 2.531
NOPCHAP1 NOP protein chaperone 1 2.52225
SHPK sedoheptulokinase 2.5064
CRYGA crystallin, gamma A 2.4931
USP6NL USP6 N-terminal like 2.4881
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.47975
AK8 adenylate kinase 8 2.32755
CCDC87 coiled-coil domain containing 87 2.32755
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.31585
EPHA3 EPH receptor A3 2.30622
ADAM11 ADAM metallopeptidase domain 11 2.30015
DHDDS dehydrodolichyl diphosphate synthase 2.2886
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.28363
NRL neural retina leucine zipper 2.27143
LOC122526780 uncharacterized LOC122526780 2.27105
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 2.2632
PYY peptide YY 2.2606
ATOH1 atonal homolog 1 (Drosophila) 2.24125
KIF20A kinesin family member 20A 2.2379
NANOS2 nanos homolog 2 (Drosophila) 2.2266
TEC tec protein tyrosine kinase 2.22215
AXIN1 axin 1 2.2092
HMGN2 high mobility group nucleosomal binding domain 2 2.20545
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 2.205
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 2.19725
NEUROD2 neuronal differentiation 2 2.17965
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.1722
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2.16057
SYNGR4 synaptogyrin 4 2.15775
FFAR3 free fatty acid receptor 3 2.1554
DCLRE1B DNA cross-link repair 1B 2.1501
NEUROD1 neuronal differentiation 1 2.1406
CELA3A chymotrypsin-like elastase family, member 3A 2.13675
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.12945
HBD hemoglobin, delta 2.12075
VWA7 von Willebrand factor A domain containing 7 2.12065
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 2.1116
GJD2 gap junction protein, delta 2, 36kDa 2.1047
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.09665
INSL5 insulin-like 5 2.09555
GUK1 guanylate kinase 1 2.0861
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.08295
CLCA1 chloride channel accessory 1 2.08235
MROH7 maestro heat-like repeat family member 7 2.0739
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.07335
CHRM2 cholinergic receptor, muscarinic 2 2.05945
GLRA2 glycine receptor, alpha 2 2.0589
ARSL arylsulfatase L 2.05815
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.0538
GCG glucagon 2.04595
MUC2 mucin 2, oligomeric mucus/gel-forming 2.04295
REG1A regenerating islet-derived 1 alpha 2.0397
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.03163
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.02645
BMP8B bone morphogenetic protein 8b 2.02135
FPGS folylpolyglutamate synthase 2.01875
AJAP1 adherens junctions associated protein 1 2.01489
EVL Enah/Vasp-like 2.0106
DNAH2 dynein, axonemal, heavy chain 2 2.0043
NEUROG1 neurogenin 1 2.0037

decreased expression

Symbol Name Standardized Value
ACAA1 acetyl-CoA acyltransferase 1 -5.34845
SLC35F2 solute carrier family 35, member F2 -4.9474
LDHD lactate dehydrogenase D -4.861
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.72715
GTPBP8 GTP-binding protein 8 (putative) -4.66665
TLCD3A TLC domain containing 3A -4.47185
CCNB2 cyclin B2 -4.13115
HLA-DMA major histocompatibility complex, class II, DM alpha -4.068
ZNF586 zinc finger protein 586 -3.7736
ANKRD10 ankyrin repeat domain 10 -3.65545
OXA1L oxidase (cytochrome c) assembly 1-like -3.22375
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.98301
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.9187
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.84395
TXNDC9 thioredoxin domain containing 9 -2.49255
REEP5 receptor accessory protein 5 -2.4347
CD58 CD58 molecule -2.4138
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -2.34
MTA1 metastasis associated 1 -2.26557
PLA2G15 phospholipase A2, group XV -2.1095
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C -2.08195
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.06845
BCAS1 breast carcinoma amplified sequence 1 -2.04465
AKAP13 A kinase (PRKA) anchor protein 13 -2.0237