CRCGN008_HEPG2_24H:F11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

118 genes differentially expressed following the CRCGN008_HEPG2_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 10.0
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.23915
ATP11B ATPase, class VI, type 11B 5.2324
E2F2 E2F transcription factor 2 5.2216
ANO1 anoctamin 1, calcium activated chloride channel 5.1818
DENND2D DENN/MADD domain containing 2D 5.107
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.88785
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.81265
STK10 serine/threonine kinase 10 4.77878
DYNLT3 dynein, light chain, Tctex-type 3 4.77555
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.60325
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.5648
TESK1 testis-specific kinase 1 4.3391
PPARG peroxisome proliferator-activated receptor gamma 4.3147
ZFP36 ZFP36 ring finger protein 3.9621
PRR15L proline rich 15-like 3.90395
CYCS cytochrome c, somatic 3.2368
CHN1 chimerin 1 3.17515
CEP57 centrosomal protein 57kDa 3.12931
SH3D19 SH3 domain containing 19 3.0293
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.02195
SLC75A1 solute carrier family 75 member 1 3.00815
CORO1A coronin, actin binding protein, 1A 2.9441
VGLL4 vestigial-like family member 4 2.9319
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.87425
NPDC1 neural proliferation, differentiation and control, 1 2.69025
CYB561 cytochrome b561 2.61512
SOCS2 suppressor of cytokine signaling 2 2.56535
RAB21 RAB21, member RAS oncogene family 2.5436
EPHA3 EPH receptor A3 2.4175
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.41078
NADSYN1 NAD synthetase 1 2.40485
MSH5 mutS homolog 5 2.39895
FCHSD2 FCH and double SH3 domains 2 2.35605
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.342
AKIRIN1 akirin 1 2.3282
LAMB3 laminin, beta 3 2.31525
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.2493
COL17A1 collagen, type XVII, alpha 1 2.238
FBXL6 F-box and leucine-rich repeat protein 6 2.2279
VIL1 villin 1 2.22225
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.20285
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.1824
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.1367
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 2.10685
GJB1 gap junction protein, beta 1, 32kDa 2.09095
GDF7 growth differentiation factor 7 2.07155
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.06055
SDC1 syndecan 1 2.04463
FAM168B family with sequence similarity 168, member B 2.0423
GPX4 glutathione peroxidase 4 2.0378
CRTAP cartilage associated protein 2.01975
LINC02762 long intergenic non-protein coding RNA 2762 2.0025

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -7.39445
DUSP6 dual specificity phosphatase 6 -5.6638
LDHD lactate dehydrogenase D -5.6404
MRPS2 mitochondrial ribosomal protein S2 -5.26285
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.2084
ADI1 acireductone dioxygenase 1 -5.10545
THAP11 THAP domain containing 11 -4.8987
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.80702
KDM3A lysine (K)-specific demethylase 3A -4.6911
PCNA proliferating cell nuclear antigen -4.6007
ARFIP2 ADP-ribosylation factor interacting protein 2 -4.56265
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.4588
HLA-DMA major histocompatibility complex, class II, DM alpha -4.3329
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.8381
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.79215
CD320 CD320 molecule -3.7667
MAPK13 mitogen-activated protein kinase 13 -3.7154
TCTN1 tectonic family member 1 -3.6789
YME1L1 YME1-like 1 ATPase -3.60645
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.32873
HSPA8 heat shock 70kDa protein 8 -3.28672
HEATR1 HEAT repeat containing 1 -3.23695
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.2213
WASHC4 WASH complex subunit 4 -3.18413
TLCD3A TLC domain containing 3A -3.05
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.92272
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.80335
SNX11 sorting nexin 11 -2.72438
FASTKD5 FAST kinase domains 5 -2.72235
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.70225
MLYCD malonyl-CoA decarboxylase -2.65375
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.56755
NUP155 nucleoporin 155kDa -2.4947
TTC33 tetratricopeptide repeat domain 33 -2.43955
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.38615
TMEM186 transmembrane protein 186 -2.36975
TENT2 terminal nucleotidyltransferase 2 -2.35005
AACS acetoacetyl-CoA synthetase -2.32845
NRSN2 neurensin 2 -2.28225
ISCU iron-sulfur cluster assembly enzyme -2.2802
CD36 CD36 molecule (thrombospondin receptor) -2.24145
PNPLA3 patatin-like phospholipase domain containing 3 -2.23505
ICAM3 intercellular adhesion molecule 3 -2.20585
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.1955
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough -2.19263
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.17285
WDR70 WD repeat domain 70 -2.15435
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1539
PARG poly (ADP-ribose) glycohydrolase -2.15295
NALF2 NALCN channel auxiliary factor 2 -2.14985
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) -2.1272
PPL periplakin -2.11515
OSMR oncostatin M receptor -2.1057
CRIP2 cysteine-rich protein 2 -2.102
PDZD2 PDZ domain containing 2 -2.10032
NLK nemo-like kinase -2.09115
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -2.08895
TRIM38 tripartite motif containing 38 -2.08212
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.07035
CCNT1 cyclin T1 -2.06495
CRYAB crystallin, alpha B -2.0589
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.0418
S100A12 S100 calcium binding protein A12 -2.02335
KCTD14 potassium channel tetramerization domain containing 14 -2.0216
TMEM214 transmembrane protein 214 -2.01525