CRCGN008_HEPG2_24H:F12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

119 genes differentially expressed following the CRCGN008_HEPG2_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.23855
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.96445
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.8935
PPARG peroxisome proliferator-activated receptor gamma 4.87115
RPL39L ribosomal protein L39-like 4.8061
GRWD1 glutamate-rich WD repeat containing 1 4.67955
RRAGA Ras-related GTP binding A 4.44885
ABHD6 abhydrolase domain containing 6 4.12045
BIRC2 baculoviral IAP repeat containing 2 4.09185
CHN1 chimerin 1 4.0831
CARMIL1 capping protein regulator and myosin 1 linker 1 4.0347
GATA3 GATA binding protein 3 3.61077
MSRA methionine sulfoxide reductase A 3.5574
MAP7 microtubule-associated protein 7 3.40823
TBPL1 TBP-like 1 3.1688
TIAM1 T-cell lymphoma invasion and metastasis 1 3.05082
NUP93 nucleoporin 93kDa 3.0352
LPAR2 lysophosphatidic acid receptor 2 2.7922
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.70487
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.66015
SSBP2 single-stranded DNA binding protein 2 2.56745
BPHL biphenyl hydrolase-like (serine hydrolase) 2.55745
TMEM14A transmembrane protein 14A 2.5211
PLSCR3 phospholipid scramblase 3 2.52002
TNIP1 TNFAIP3 interacting protein 1 2.49725
RABEPK Rab9 effector protein with kelch motifs 2.4728
WDTC1 WD and tetratricopeptide repeats 1 2.35985
LOC122526780 uncharacterized LOC122526780 2.28045
ANKRD40 ankyrin repeat domain 40 2.2553
ZNF665 zinc finger protein 665 2.25275
PAQR4 progestin and adipoQ receptor family member IV 2.20865
RBKS ribokinase 2.17945
KIF20A kinesin family member 20A 2.17435
ERBIN erbb2 interacting protein 2.09545
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.0902
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 2.0823
EXOSC5 exosome component 5 2.0211
MCM3 minichromosome maintenance complex component 3 2.01465

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.017
TLCD3A TLC domain containing 3A -5.6374
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -5.4627
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.0596
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.91535
NRIP1 nuclear receptor interacting protein 1 -4.8359
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7331
C2CD5 C2 calcium-dependent domain containing 5 -4.72335
CCNB2 cyclin B2 -4.23765
ARID5B AT rich interactive domain 5B (MRF1-like) -4.2016
FGFR4 fibroblast growth factor receptor 4 -4.12745
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.6264
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.5715
GNAS GNAS complex locus -3.5489
FHL2 four and a half LIM domains 2 -3.50555
OXA1L oxidase (cytochrome c) assembly 1-like -3.41735
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough -3.01955
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.95088
CDC25B cell division cycle 25B -2.78805
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -2.7131
DES desmin -2.64103
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) -2.62165
HMG20B high mobility group 20B -2.57877
RBMY1J RNA binding motif protein, Y-linked, family 1, member J -2.569
ZW10 zw10 kinetochore protein -2.5239
LAG3 lymphocyte-activation gene 3 -2.4927
RBM41 RNA binding motif protein 41 -2.47005
MGP matrix Gla protein -2.4551
FGF9 fibroblast growth factor 9 -2.37175
CHIC2 cysteine-rich hydrophobic domain 2 -2.3659
CFB complement factor B -2.35055
ZMPSTE24 zinc metallopeptidase STE24 -2.3395
TXNDC9 thioredoxin domain containing 9 -2.31715
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -2.30837
PNMA3 paraneoplastic Ma antigen 3 -2.3021
OPRD1 opioid receptor, delta 1 -2.25785
CRYGB crystallin, gamma B -2.25565
RINT1 RAD50 interactor 1 -2.25095
RBM15B RNA binding motif protein 15B -2.24605
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.22525
PDHX pyruvate dehydrogenase complex, component X -2.22205
S1PR5 sphingosine-1-phosphate receptor 5 -2.20445
PLXNB3 plexin B3 -2.1968
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 -2.19338
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -2.17765
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -2.17225
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -2.16685
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -2.158
MTMR11 myotubularin related protein 11 -2.1539
PPP1R12B protein phosphatase 1, regulatory subunit 12B -2.14978
NIPSNAP2 nipsnap homolog 2 -2.1474
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.13465
NCR3 natural cytotoxicity triggering receptor 3 -2.13435
GPR22 G protein-coupled receptor 22 -2.13095
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 -2.1308
SETBP1 SET binding protein 1 -2.1259
NFIA nuclear factor I/A -2.12098
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D -2.11865
MYH11 myosin, heavy chain 11, smooth muscle -2.11516
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.1043
POPDC2 popeye domain containing 2 -2.09855
GOLGA6L9 golgin A6 family-like 9 -2.09375
MTREX Mtr4 exosome RNA helicase -2.0923
GCG glucagon -2.09065
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.0885
HOXD11 homeobox D11 -2.085
GOLGA6B golgin A6 family, member B -2.08225
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.07615
TBX4 T-box 4 -2.07495
OLFM4 olfactomedin 4 -2.06175
DEFA5 defensin, alpha 5, Paneth cell-specific -2.0615
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.0529
ZNF221 zinc finger protein 221 -2.05055
GIPR gastric inhibitory polypeptide receptor -2.0495
WNT3 wingless-type MMTV integration site family, member 3 -2.032
ZNF33B zinc finger protein 33B -2.0187
UCKL1 uridine-cytidine kinase 1-like 1 -2.0148
FIP1L1 factor interacting with PAPOLA and CPSF1 -2.00075
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -2.00055