| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | dehydroisoandosterone 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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87 genes differentially expressed following the CRCGN008_HEPG2_24H:F13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 10.0 |
| CHMP6 | charged multivesicular body protein 6 | 9.61995 |
| CHN1 | chimerin 1 | 6.10825 |
| MYLK | myosin light chain kinase | 5.2591 |
| GSTZ1 | glutathione S-transferase zeta 1 | 4.9446 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.8431 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 4.61508 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 4.3605 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 4.09885 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 3.88478 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.8142 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.39412 |
| CYCS | cytochrome c, somatic | 3.30825 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 3.27297 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 3.1974 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 3.12411 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.95473 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.92985 |
| TBC1D31 | TBC1 domain family, member 31 | 2.92025 |
| H2BC12 | H2B clustered histone 12 | 2.86772 |
| TBP | TATA box binding protein | 2.83585 |
| TSPAN6 | tetraspanin 6 | 2.83225 |
| SCRN1 | secernin 1 | 2.80155 |
| PKN1 | protein kinase N1 | 2.8009 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.78255 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | 2.73798 |
| CHEK2 | checkpoint kinase 2 | 2.65727 |
| ZNF589 | zinc finger protein 589 | 2.63103 |
| AXIN1 | axin 1 | 2.59915 |
| ALDOC | aldolase C, fructose-bisphosphate | 2.4569 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 2.3296 |
| TRIB3 | tribbles pseudokinase 3 | 2.2853 |
| APP | amyloid beta (A4) precursor protein | 2.26627 |
| THOP1 | thimet oligopeptidase 1 | 2.2093 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 2.16415 |
| METTL8 | methyltransferase like 8 | 2.13615 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 2.12265 |
| UGDH | UDP-glucose 6-dehydrogenase | 2.09595 |
| SMYD5 | SMYD family member 5 | 2.0539 |
| CCL4 | chemokine (C-C motif) ligand 4 | 2.02405 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 2.01745 |
| CCL3L3 | chemokine (C-C motif) ligand 3-like 3 | 2.01035 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 2.0099 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | 2.00095 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -10.0 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -6.4502 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -5.3363 |
| GOLT1B | golgi transport 1B | -5.1319 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.9413 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -4.8061 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -4.76445 |
| FASTKD5 | FAST kinase domains 5 | -4.5472 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -4.33225 |
| MAPK13 | mitogen-activated protein kinase 13 | -4.11545 |
| CCNB1 | cyclin B1 | -4.03945 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.94995 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.70385 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.37105 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -3.23815 |
| ZW10 | zw10 kinetochore protein | -3.1612 |
| CDK1 | cyclin-dependent kinase 1 | -2.99352 |
| ILK | integrin-linked kinase | -2.9526 |
| S100A4 | S100 calcium binding protein A4 | -2.8551 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.77312 |
| FHL2 | four and a half LIM domains 2 | -2.76535 |
| CDC25B | cell division cycle 25B | -2.73415 |
| CLIC4 | chloride intracellular channel 4 | -2.66793 |
| IER3 | immediate early response 3 | -2.5549 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.5543 |
| MAP7 | microtubule-associated protein 7 | -2.54633 |
| DHX38 | DEAH (Asp-Glu-Ala-His) box polypeptide 38 | -2.36075 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.2803 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | -2.21925 |
| MCOLN3 | mucolipin 3 | -2.20955 |
| INPPL1 | inositol polyphosphate phosphatase-like 1 | -2.20525 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -2.1997 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.13083 |
| IPO8 | importin 8 | -2.11055 |
| LYRM1 | LYR motif containing 1 | -2.09405 |
| TUBA4B | tubulin, alpha 4b | -2.0882 |
| CHD9NB | CHD9 neighbor | -2.0775 |
| ANKRD6 | ankyrin repeat domain 6 | -2.06675 |
| PRR7 | proline rich 7 (synaptic) | -2.06195 |
| GSTO1 | glutathione S-transferase omega 1 | -2.0424 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -2.04008 |
| APOD | apolipoprotein D | -2.03865 |
| AURKB | aurora kinase B | -2.03685 |
