CRCGN008_HEPG2_24H:F15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dehydroisoandosterone 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN008_HEPG2_24H:F15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.81935
DYNLT3 dynein, light chain, Tctex-type 3 5.73125
NMU neuromedin U 4.62005
ADRB2 adrenoceptor beta 2, surface 4.5355
PPARG peroxisome proliferator-activated receptor gamma 4.4311
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.69853
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.5197
PLSCR1 phospholipid scramblase 1 3.30875
TIAM1 T-cell lymphoma invasion and metastasis 1 3.06685
WASF3 WAS protein family, member 3 2.95965
JADE2 jade family PHD finger 2 2.80105
HLA-DRA major histocompatibility complex, class II, DR alpha 2.70732
SSBP2 single-stranded DNA binding protein 2 2.66578
ADAT1 adenosine deaminase, tRNA-specific 1 2.56325
TNIP1 TNFAIP3 interacting protein 1 2.5325
TBP TATA box binding protein 2.34635
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.31095
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.19166
CYCS cytochrome c, somatic 2.15155
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 2.0538
ZNF394 zinc finger protein 394 2.03295
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 2.027
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.02465
NKAPD1 NKAP domain containing 1 2.02
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.0184

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.22005
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -5.19915
CAB39 calcium binding protein 39 -5.0728
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.85155
CDC20 cell division cycle 20 -4.66275
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.5084
MAPK13 mitogen-activated protein kinase 13 -4.28317
HLA-DMA major histocompatibility complex, class II, DM alpha -4.28
CCNB2 cyclin B2 -4.2176
MAP7 microtubule-associated protein 7 -4.1145
LOC124907782 dual specificity protein phosphatase 22 -3.39955
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -3.2708
OXA1L oxidase (cytochrome c) assembly 1-like -3.2088
WASHC4 WASH complex subunit 4 -2.98888
CLIC4 chloride intracellular channel 4 -2.9099
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.81565
CCNB1 cyclin B1 -2.8126
FGFR4 fibroblast growth factor receptor 4 -2.70082
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.60955
PDHX pyruvate dehydrogenase complex, component X -2.44157
SNX11 sorting nexin 11 -2.4393
FSHB follicle stimulating hormone, beta polypeptide -2.34355
CSHL1 chorionic somatomammotropin hormone-like 1 -2.27005
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.2272
ARHGAP22 Rho GTPase activating protein 22 -2.1925
PGM1 phosphoglucomutase 1 -2.17245
MCM6 minichromosome maintenance complex component 6 -2.1587
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.13085
GH2 growth hormone 2 -2.12088
POU1F1 POU class 1 homeobox 1 -2.11795
SCGB1D2 secretoglobin, family 1D, member 2 -2.1172
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 -2.07425
FOXL2 forkhead box L2 -2.0721
CSH2 chorionic somatomammotropin hormone 2 -2.0633
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.02898
GH1 growth hormone 1 -2.01834
CHD6 chromodomain helicase DNA binding protein 6 -2.01735