CRCGN008_HEPG2_24H:F17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dehydroisoandosterone 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

234 genes differentially expressed following the CRCGN008_HEPG2_24H:F17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 8.23665
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 6.3488
NPDC1 neural proliferation, differentiation and control, 1 5.90015
H2BC21 H2B clustered histone 21 5.80685
NMU neuromedin U 5.7723
ARL4C ADP-ribosylation factor-like 4C 4.98045
TBC1D31 TBC1 domain family, member 31 4.49135
HTRA1 HtrA serine peptidase 1 4.46665
BPHL biphenyl hydrolase-like (serine hydrolase) 4.46475
TESK1 testis-specific kinase 1 4.37985
SHB Src homology 2 domain containing adaptor protein B 4.3471
CCNA1 cyclin A1 4.3074
FOXO4 forkhead box O4 4.21935
EGF epidermal growth factor 4.1936
ZNF274 zinc finger protein 274 4.1509
IL1B interleukin 1, beta 4.08213
TARBP1 TAR (HIV-1) RNA binding protein 1 4.00475
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 3.99885
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.9301
LOC122526780 uncharacterized LOC122526780 3.87835
MCM3 minichromosome maintenance complex component 3 3.7709
ZFP36 ZFP36 ring finger protein 3.3349
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.29967
CDCA4 cell division cycle associated 4 3.26915
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.1545
LPAR2 lysophosphatidic acid receptor 2 3.13685
AXIN1 axin 1 3.1106
CLSTN3 calsyntenin 3 3.0824
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.06195
TRAP1 TNF receptor-associated protein 1 3.0402
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.9251
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.88385
ADGRD2 adhesion G protein-coupled receptor D2 2.8446
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.83512
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 2.8316
CORO1A coronin, actin binding protein, 1A 2.8248
SLC49A3 solute carrier family 49 member 3 2.8128
TCF15 transcription factor 15 (basic helix-loop-helix) 2.8012
ZNF646 zinc finger protein 646 2.79985
PTK2 protein tyrosine kinase 2 2.7813
RGPD1 RANBP2-like and GRIP domain containing 1 2.7456
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.74265
CNPY4 canopy FGF signaling regulator 4 2.7177
SSBP2 single-stranded DNA binding protein 2 2.70582
ZNG1A Zn regulated GTPase metalloprotein activator 1A 2.694
ACAD10 acyl-CoA dehydrogenase family, member 10 2.68975
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.68565
RCE1 Ras converting CAAX endopeptidase 1 2.64335
KIAA0319 KIAA0319 2.6255
SOCS2 suppressor of cytokine signaling 2 2.61567
EML3 echinoderm microtubule associated protein like 3 2.58915
SETD1A SET domain containing 1A 2.5866
KIFBP kinesin family binding protein 2.57635
CATSPERH catsper channel auxiliary subunit eta 2.5733
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.56435
TRIM13 tripartite motif containing 13 2.55555
WDCP WD repeat and coiled coil containing 2.49985
BBC3 BCL2 binding component 3 2.4957
RNF167 ring finger protein 167 2.4907
H2BC3 H2B clustered histone 3 2.4888
ECHDC2 enoyl CoA hydratase domain containing 2 2.4757
ATP11B ATPase, class VI, type 11B 2.47475
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.46975
CELF3 CUGBP, Elav-like family member 3 2.46552
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.46
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.4443
FBXL6 F-box and leucine-rich repeat protein 6 2.41805
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 2.41415
SHARPIN SHANK-associated RH domain interactor 2.402
CLDN6 claudin 6 2.398
PCDHA10 protocadherin alpha 10 2.39695
ST20-MTHFS ST20-MTHFS readthrough 2.39235
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.38525
C2CD3 C2 calcium-dependent domain containing 3 2.37808
FAM110D family with sequence similarity 110, member D 2.37205
FABP2 fatty acid binding protein 2, intestinal 2.371
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.36575
WDR7 WD repeat domain 7 2.34795
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 2.3323
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.33045
CCDC69 coiled-coil domain containing 69 2.3068
ARID4B AT rich interactive domain 4B (RBP1-like) 2.3059
ZNF302 zinc finger protein 302 2.3047
ZNF227 zinc finger protein 227 2.28525
ZC3H4 zinc finger CCCH-type containing 4 2.28345
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.28145
MYH9 myosin, heavy chain 9, non-muscle 2.27605
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 2.269
CIAO3 cytosolic iron-sulfur assembly component 3 2.2688
MUTYH mutY homolog 2.26845
RGCC regulator of cell cycle 2.26675
FLNA filamin A, alpha 2.25405
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 2.24865
PKN1 protein kinase N1 2.2453
PLN phospholamban 2.23405
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.2295
KLK1 kallikrein 1 2.22625
TNF tumor necrosis factor 2.2243
TRAF5 TNF receptor-associated factor 5 2.2181
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2.215
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.21015
TRIM11 tripartite motif containing 11 2.20895
RSF1 remodeling and spacing factor 1 2.2034
DENND2D DENN/MADD domain containing 2D 2.1962
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.19135
NT5DC2 5'-nucleotidase domain containing 2 2.1723
MYOG myogenin (myogenic factor 4) 2.17085
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.1636
ZNF787 zinc finger protein 787 2.16285
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.15445
QPCT glutaminyl-peptide cyclotransferase 2.1481
IGFALS insulin-like growth factor binding protein, acid labile subunit 2.1435
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 2.10815
LRRC8B leucine rich repeat containing 8 family, member B 2.10803
INHA inhibin, alpha 2.10655
SFRP5 secreted frizzled-related protein 5 2.0929
PRKCQ protein kinase C, theta 2.09208
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.09185
UNC13A unc-13 homolog A (C. elegans) 2.08945
JUN jun proto-oncogene 2.08768
EMC10 ER membrane protein complex subunit 10 2.0858
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.08418
HMX1 H6 family homeobox 1 2.08265
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.08005
RBM41 RNA binding motif protein 41 2.0788
ADGRG1 adhesion G protein-coupled receptor G1 2.0749
RGS19 regulator of G-protein signaling 19 2.06785
FAIM Fas apoptotic inhibitory molecule 2.06725
CD1E CD1e molecule 2.06673
S100A14 S100 calcium binding protein A14 2.0536
STX1A syntaxin 1A (brain) 2.05
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 2.0423
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.04025
LTB lymphotoxin beta (TNF superfamily, member 3) 2.03675
IQCC IQ motif containing C 2.0335
ATAD2 ATPase family, AAA domain containing 2 2.02075
ZNF362 zinc finger protein 362 2.0106
TOPBP1 topoisomerase (DNA) II binding protein 1 2.00955
RIN1 Ras and Rab interactor 1 2.0085
ZNF711 zinc finger protein 711 2.0076
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.0054
H2AC25 H2A clustered histone 25 2.0048
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.00145

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -8.1852
DERA deoxyribose-phosphate aldolase (putative) -8.15055
ICAM3 intercellular adhesion molecule 3 -6.45765
LAP3 leucine aminopeptidase 3 -5.23855
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.0
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.9284
TLCD3A TLC domain containing 3A -4.8676
PCNA proliferating cell nuclear antigen -4.81965
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.6623
HLA-DMA major histocompatibility complex, class II, DM alpha -4.22155
FGFR4 fibroblast growth factor receptor 4 -4.18835
CAB39 calcium binding protein 39 -4.02325
ZNF586 zinc finger protein 586 -3.6604
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -3.6474
PRPF4 pre-mRNA processing factor 4 -3.60067
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -3.4854
LOC124907782 dual specificity protein phosphatase 22 -3.3433
FBXO7 F-box protein 7 -3.3068
HEATR1 HEAT repeat containing 1 -3.21988
TCTN1 tectonic family member 1 -3.20105
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.9176
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.84355
RPL26L1 ribosomal protein L26-like 1 -2.81225
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.80572
LYRM1 LYR motif containing 1 -2.73685
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.7102
EXOSC10 exosome component 10 -2.6887
TRIM25 tripartite motif containing 25 -2.6175
CHRM4 cholinergic receptor, muscarinic 4 -2.60675
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.56065
MED16 mediator complex subunit 16 -2.55605
SIL1 SIL1 nucleotide exchange factor -2.44015
MRPS16 mitochondrial ribosomal protein S16 -2.42655
RCN3 reticulocalbin 3, EF-hand calcium binding domain -2.42232
UBFD1 ubiquitin family domain containing 1 -2.39865
RIOX2 ribosomal oxygenase 2 -2.3829
GTF2A2 general transcription factor IIA, 2, 12kDa -2.3797
HDAC2 histone deacetylase 2 -2.35825
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.3525
TSKU tsukushi, small leucine rich proteoglycan -2.3468
GRWD1 glutamate-rich WD repeat containing 1 -2.34035
CHPF2 chondroitin polymerizing factor 2 -2.33725
CCDC90B coiled-coil domain containing 90B -2.3243
FAM174C family with sequence similarity 174 member C -2.3152
AARSD1 alanyl-tRNA synthetase domain containing 1 -2.3133
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.30905
COG7 component of oligomeric golgi complex 7 -2.3002
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.29675
PCDH17 protocadherin 17 -2.2911
DCTN5 dynactin 5 (p25) -2.28632
FCGRT Fc fragment of IgG, receptor, transporter, alpha -2.28315
MRPL11 mitochondrial ribosomal protein L11 -2.2758
ZMAT4 zinc finger, matrin-type 4 -2.27075
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.25865
GTF2H5 general transcription factor IIH, polypeptide 5 -2.2538
STAMBP STAM binding protein -2.24215
KANSL3 KAT8 regulatory NSL complex subunit 3 -2.2412
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A -2.23383
PCDHB13 protocadherin beta 13 -2.21775
SLC67A1 solute carrier family 67 member 1 -2.1971
BUD31 BUD31 homolog (S. cerevisiae) -2.18475
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 -2.17715
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -2.1729
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.15585
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.15155
PRRC1 proline-rich coiled-coil 1 -2.14955
BAG2 BCL2-associated athanogene 2 -2.13935
ILK integrin-linked kinase -2.13605
SEC61B Sec61 beta subunit -2.13135
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.12308
STX18 syntaxin 18 -2.111
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 -2.11055
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.1067
NLRP2B NLR family pyrin domain containing 2B -2.09855
PAX1 paired box 1 -2.0876
RPS26 ribosomal protein S26 -2.08435
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.08192
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 -2.07952
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.0674
LY86 lymphocyte antigen 86 -2.06665
DDB2 damage-specific DNA binding protein 2, 48kDa -2.0607
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -2.0512
ZNF136 zinc finger protein 136 -2.0487
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.04295
TNNC1 troponin C type 1 (slow) -2.03627
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.0339
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.03365
LAGE3 L antigen family, member 3 -2.03275
TTLL1 tubulin tyrosine ligase-like family member 1 -2.0238
LRRC61 leucine rich repeat containing 61 -2.0127
ZDHHC24 zinc finger, DHHC-type containing 24 -2.00885