CRCGN008_HEPG2_24H:F18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dehydroisoandosterone 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN008_HEPG2_24H:F18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
GSTZ1 glutathione S-transferase zeta 1 7.9944
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 5.1912
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.79255
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.6482
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.6449
VAV3 vav 3 guanine nucleotide exchange factor 4.55315
STK10 serine/threonine kinase 10 4.54373
PPARG peroxisome proliferator-activated receptor gamma 4.42665
STIMATE STIM activating enhancer 4.13655
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.12625
SSBP2 single-stranded DNA binding protein 2 4.09847
ABHD6 abhydrolase domain containing 6 4.07998
PEX11A peroxisomal biogenesis factor 11 alpha 4.07177
PRR15L proline rich 15-like 3.8396
MAMLD1 mastermind-like domain containing 1 3.79705
TIAM1 T-cell lymphoma invasion and metastasis 1 3.36262
CHN1 chimerin 1 3.25135
CYCS cytochrome c, somatic 3.1715
JADE2 jade family PHD finger 2 3.0062
CCNF cyclin F 2.8554
TNF tumor necrosis factor 2.8529
GPER1 G protein-coupled estrogen receptor 1 2.78045
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.74417
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.69
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.6191
METRN meteorin, glial cell differentiation regulator 2.55315
ADAT1 adenosine deaminase, tRNA-specific 1 2.53205
CRTAP cartilage associated protein 2.50975
TXNL4B thioredoxin-like 4B 2.49115
PDZRN3 PDZ domain containing ring finger 3 2.4687
MATN2 matrilin 2 2.3569
POMT2 protein-O-mannosyltransferase 2 2.3239
ANO1 anoctamin 1, calcium activated chloride channel 2.28955
PLAGL2 pleiomorphic adenoma gene-like 2 2.24552
H2AZ2 H2A.Z variant histone 2 2.23672
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.1574
CEND1 cell cycle exit and neuronal differentiation 1 2.10665
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.1018
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.05765
NPIPB6 nuclear pore complex interacting protein family, member B6 2.0484
IST1 increased sodium tolerance 1 homolog (yeast) 2.0372
TRMO tRNA methyltransferase O 2.02265
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 2.02255
SP8 Sp8 transcription factor 2.01997
A1CF APOBEC1 complementation factor 2.00215

decreased expression

Symbol Name Standardized Value
RFC2 replication factor C (activator 1) 2, 40kDa -7.41542
ARID5B AT rich interactive domain 5B (MRF1-like) -5.57255
TRIB3 tribbles pseudokinase 3 -5.32945
LDHD lactate dehydrogenase D -5.3257
NT5DC2 5'-nucleotidase domain containing 2 -5.2125
GDF15 growth differentiation factor 15 -5.0
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.90325
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.8594
CD320 CD320 molecule -4.8267
ZNF586 zinc finger protein 586 -4.6269
TSPAN4 tetraspanin 4 -4.38975
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -4.1553
SLC35F2 solute carrier family 35, member F2 -4.0419
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.53145
PRPF4 pre-mRNA processing factor 4 -3.4915
VDAC1 voltage-dependent anion channel 1 -3.4413
WASHC4 WASH complex subunit 4 -3.03252
HSPA8 heat shock 70kDa protein 8 -3.01365
FOS FBJ murine osteosarcoma viral oncogene homolog -2.74935
GCLM glutamate-cysteine ligase, modifier subunit -2.5633
OXA1L oxidase (cytochrome c) assembly 1-like -2.53685
CCNB1 cyclin B1 -2.453
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.39605
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 -2.32955
RGS2 regulator of G-protein signaling 2 -2.2868
KRT18 keratin 18, type I -2.2492
LACTB2 lactamase, beta 2 -2.0987
CGRRF1 cell growth regulator with ring finger domain 1 -2.0819
MOK MOK protein kinase -2.0348
FBXL12 F-box and leucine-rich repeat protein 12 -2.00155