CRCGN008_HEPG2_24H:F20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triprolidine.hcl monohydrate 19.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN008_HEPG2_24H:F20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 6.42567
MYLK myosin light chain kinase 5.32895
SMIM40 small integral membrane protein 40 5.29735
NOTCH1 notch 1 5.1637
MINDY1 MINDY lysine 48 deubiquitinase 1 4.6193
CHN1 chimerin 1 4.32475
EGF epidermal growth factor 3.8465
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.83245
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.31958
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.2283
SSBP2 single-stranded DNA binding protein 2 3.01923
CHEK2 checkpoint kinase 2 2.65462
MAP7 microtubule-associated protein 7 2.61318
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.4487
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.43433
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.4248
GATA2 GATA binding protein 2 2.34588
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.1808
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 2.1405
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.06475
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.0561
HPN hepsin 2.0189

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.394
TUBB6 tubulin, beta 6 class V -5.613
CD320 CD320 molecule -5.41785
THAP11 THAP domain containing 11 -5.334
DNM1L dynamin 1-like -5.0
SLC35F2 solute carrier family 35, member F2 -4.9615
TLCD3A TLC domain containing 3A -4.96105
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.95355
SMNDC1 survival motor neuron domain containing 1 -4.8077
ZNF586 zinc finger protein 586 -4.80185
CCNB2 cyclin B2 -4.7139
VDAC1 voltage-dependent anion channel 1 -4.28285
FASTKD5 FAST kinase domains 5 -4.11425
ARID5B AT rich interactive domain 5B (MRF1-like) -4.0511
MAPK13 mitogen-activated protein kinase 13 -3.878
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.81568
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.78045
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.624
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.3309
FBXL12 F-box and leucine-rich repeat protein 12 -3.3014
TMEM230 transmembrane protein 230 -3.16105
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.9451
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.7962
NRIP1 nuclear receptor interacting protein 1 -2.62655
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.45883
HSPA8 heat shock 70kDa protein 8 -2.42693
COG4 component of oligomeric golgi complex 4 -2.40565
DDRGK1 DDRGK domain containing 1 -2.3555
RESF1 retroelement silencing factor 1 -2.3449
ZNF426 zinc finger protein 426 -2.20205
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.17385
MAVS mitochondrial antiviral signaling protein -2.14275
EMC8 ER membrane protein complex subunit 8 -2.12455
UBXN6 UBX domain protein 6 -2.1229
ZNF544 zinc finger protein 544 -2.11435
PYCARD PYD and CARD domain containing -2.02455
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.0175