CRCGN008_HEPG2_24H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triprolidine.hcl monohydrate 1.19 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN008_HEPG2_24H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.35975
EAPP E2F-associated phosphoprotein 5.0604
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.00905
DYNLT3 dynein, light chain, Tctex-type 3 4.98785
NMU neuromedin U 4.411
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 4.3232
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.65755
CHN1 chimerin 1 3.4855
SFTPB surfactant protein B 3.21902
ANO10 anoctamin 10 2.9907
BIRC2 baculoviral IAP repeat containing 2 2.7166
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.59643
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.54548
EVL Enah/Vasp-like 2.4683
SOCS2 suppressor of cytokine signaling 2 2.4427
GATA2 GATA binding protein 2 2.40863
CYCS cytochrome c, somatic 2.2511
BRCA1 breast cancer 1, early onset 2.13595
TSPYL4 TSPY-like 4 2.0791
CEP57 centrosomal protein 57kDa 2.0615

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
DHRS7 dehydrogenase/reductase (SDR family) member 7 -7.98055
KDM3A lysine (K)-specific demethylase 3A -5.62235
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.33725
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.96985
CCNB1 cyclin B1 -4.942
C2CD5 C2 calcium-dependent domain containing 5 -4.93915
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -4.6117
ADI1 acireductone dioxygenase 1 -4.42255
MAPK13 mitogen-activated protein kinase 13 -4.2489
TWF2 twinfilin actin binding protein 2 -4.06195
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.71758
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.6725
PRPF4 pre-mRNA processing factor 4 -3.5372
CCNB2 cyclin B2 -3.1197
PECR peroxisomal trans-2-enoyl-CoA reductase -3.07645
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.94782
SCAND1 SCAN domain containing 1 -2.86305
FBXL12 F-box and leucine-rich repeat protein 12 -2.82815
ICAM3 intercellular adhesion molecule 3 -2.8035
MAP7 microtubule-associated protein 7 -2.5216
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.29595
ETNK1 ethanolamine kinase 1 -2.22888
PKDREJ polycystin (PKD) family receptor for egg jelly -2.19535
DDIT4 DNA-damage-inducible transcript 4 -2.171
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa -2.14353
RPRM reprimo, TP53 dependent G2 arrest mediator candidate -2.1151
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.0976
TOR1B torsin family 1, member B (torsin B) -2.09665
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.0807
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.0754
TPK1 thiamin pyrophosphokinase 1 -2.02845
ARL4A ADP-ribosylation factor-like 4A -2.0125
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 -2.00965