CRCGN008_HEPG2_24H:G01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetracycline 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

297 genes differentially expressed following the CRCGN008_HEPG2_24H:G01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 7.8028
DDIT4 DNA-damage-inducible transcript 4 6.6084
INPP1 inositol polyphosphate-1-phosphatase 6.172
CNPY3 canopy FGF signaling regulator 3 6.14855
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 5.84925
UBQLN2 ubiquilin 2 5.71475
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.63175
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.58175
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.49535
AXIN1 axin 1 5.37345
E2F2 E2F transcription factor 2 5.35705
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.31685
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.83265
ZBTB35 zinc finger and BTB domain containing 35 4.76003
BZW2 basic leucine zipper and W2 domains 2 4.69195
NMU neuromedin U 4.66275
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 4.6406
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.5073
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.26565
NOSIP nitric oxide synthase interacting protein 4.18815
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 4.1845
CCP110 centriolar coiled coil protein 110kDa 4.1716
PRR15L proline rich 15-like 4.16245
EVL Enah/Vasp-like 4.0397
AARS1 alanyl-tRNA synthetase 1 4.01555
MAP7 microtubule-associated protein 7 3.95808
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.91075
TXNL4B thioredoxin-like 4B 3.90895
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.82745
H2BC12 H2B clustered histone 12 3.78015
CCL2 chemokine (C-C motif) ligand 2 3.74975
PHGDH phosphoglycerate dehydrogenase 3.7363
FOS FBJ murine osteosarcoma viral oncogene homolog 3.69575
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 3.6706
FZD7 frizzled class receptor 7 3.63453
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.5977
TXNRD1 thioredoxin reductase 1 3.59745
RBM15B RNA binding motif protein 15B 3.5817
TARS1 threonyl-tRNA synthetase 1 3.508
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.384
PLSCR1 phospholipid scramblase 1 3.30888
TSC22D3 TSC22 domain family, member 3 3.2741
YIPF3 Yip1 domain family, member 3 3.1075
GPATCH8 G patch domain containing 8 3.04265
CDPF1 cysteine-rich, DPF motif domain containing 1 3.03435
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 3.0261
MRPS10 mitochondrial ribosomal protein S10 3.0196
RGS2 regulator of G-protein signaling 2 2.9483
TJAP1 tight junction associated protein 1 (peripheral) 2.94595
TNIP1 TNFAIP3 interacting protein 1 2.91595
GTPBP2 GTP binding protein 2 2.87625
GARS1 glycyl-tRNA synthetase 1 2.8742
TES testin LIM domain protein 2.8701
SNX6 sorting nexin 6 2.86865
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.78765
ZMIZ1 zinc finger, MIZ-type containing 1 2.7319
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.70465
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.62768
TBXA2R thromboxane A2 receptor 2.62519
ZFP36 ZFP36 ring finger protein 2.5621
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2.5106
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.5104
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.49385
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.46355
ADGRG1 adhesion G protein-coupled receptor G1 2.45423
YARS1 tyrosyl-tRNA synthetase 1 2.44325
ARHGAP5 Rho GTPase activating protein 5 2.4418
ARID4B AT rich interactive domain 4B (RBP1-like) 2.44125
UFM1 ubiquitin-fold modifier 1 2.4371
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.4314
CHIC2 cysteine-rich hydrophobic domain 2 2.42615
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.40425
NARS1 asparaginyl-tRNA synthetase 1 2.3858
CD2AP CD2-associated protein 2.3839
ENG endoglin 2.3721
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.37152
SGPP1 sphingosine-1-phosphate phosphatase 1 2.36205
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 2.35085
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.34305
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.34175
RAP1GAP2 RAP1 GTPase activating protein 2 2.3375
SPATA20 spermatogenesis associated 20 2.3347
DSG2 desmoglein 2 2.33025
SLC75A1 solute carrier family 75 member 1 2.32245
UCKL1 uridine-cytidine kinase 1-like 1 2.31975
FOSL1 FOS-like antigen 1 2.31685
UBR2 ubiquitin protein ligase E3 component n-recognin 2 2.31208
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.30875
XPOT exportin, tRNA 2.30085
EXOC5 exocyst complex component 5 2.2947
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough 2.286
PROSER1 proline and serine rich 1 2.27115
PARP2 poly (ADP-ribose) polymerase 2 2.26612
HYOU1 hypoxia up-regulated 1 2.266
CRTC3 CREB regulated transcription coactivator 3 2.26395
MRPL42 mitochondrial ribosomal protein L42 2.2304
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.2295
KPNA4 karyopherin alpha 4 (importin alpha 3) 2.22775
SEPTIN10 septin 10 2.21443
CCDC68 coiled-coil domain containing 68 2.19705
ACOT9 acyl-CoA thioesterase 9 2.18985
ANO1 anoctamin 1, calcium activated chloride channel 2.18905
UGDH UDP-glucose 6-dehydrogenase 2.1888
MAPK13 mitogen-activated protein kinase 13 2.18377
SQOR sulfide quinone oxidoreductase 2.16835
TMEM267 transmembrane protein 267 2.16145
NADSYN1 NAD synthetase 1 2.1601
H2AC6 H2A clustered histone 6 2.1445
TRAF5 TNF receptor-associated factor 5 2.13945
AKTIP AKT interacting protein 2.1361
SNW1 SNW domain containing 1 2.1222
TLR4 toll-like receptor 4 2.11635
WAC WW domain containing adaptor with coiled-coil 2.11285
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.11095
NFASC neurofascin 2.10735
IL4R interleukin 4 receptor 2.10325
BYSL bystin-like 2.10055
FNDC3A fibronectin type III domain containing 3A 2.08437
PARP6 poly (ADP-ribose) polymerase family, member 6 2.07795
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.07725
ITPRID2 ITPR interacting domain containing 2 2.0767
SPAG1 sperm associated antigen 1 2.07525
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.0738
VAT1 vesicle amine transport 1 2.0541
PDGFA platelet-derived growth factor alpha polypeptide 2.0527
IFRD1 interferon-related developmental regulator 1 2.05227
NPDC1 neural proliferation, differentiation and control, 1 2.0409
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.0397
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 2.02975
LSG1 large 60S subunit nuclear export GTPase 1 2.02135
BUD31 BUD31 homolog (S. cerevisiae) 2.0183
DCLRE1C DNA cross-link repair 1C 2.0157
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.00598
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.00405
ZNHIT6 zinc finger, HIT-type containing 6 2.00285
BICRAL BICRA like chromatin remodeling complex associated protein 2.00113

decreased expression

Symbol Name Standardized Value
TCTN1 tectonic family member 1 -8.64625
ALDOC aldolase C, fructose-bisphosphate -7.00995
PSRC1 proline/serine-rich coiled-coil 1 -6.5944
CDC20 cell division cycle 20 -6.46095
SOAT2 sterol O-acyltransferase 2 -5.96772
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -5.88793
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -5.7963
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.79155
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -5.6463
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.6134
CCNB1 cyclin B1 -5.45995
CDK1 cyclin-dependent kinase 1 -5.28213
STMN1 stathmin 1 -5.11395
CD320 CD320 molecule -4.9594
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.87295
MELK maternal embryonic leucine zipper kinase -4.6875
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.6716
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.64645
PLK1 polo-like kinase 1 -4.60335
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.5831
RFC2 replication factor C (activator 1) 2, 40kDa -4.53178
MRPS16 mitochondrial ribosomal protein S16 -4.4823
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -4.4144
CCNB2 cyclin B2 -4.1407
PGAM4 phosphoglycerate mutase family member 4 -4.06895
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.0155
CDC25B cell division cycle 25B -4.0132
FASTKD5 FAST kinase domains 5 -3.94435
AURKB aurora kinase B -3.84185
CCNA2 cyclin A2 -3.82475
BIRC5 baculoviral IAP repeat containing 5 -3.77323
PDZD2 PDZ domain containing 2 -3.74595
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.67053
GNAS GNAS complex locus -3.52477
ASF1B anti-silencing function 1B histone chaperone -3.4938
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -3.48665
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.46192
PEG10 paternally expressed 10 -3.434
DERA deoxyribose-phosphate aldolase (putative) -3.4265
ACAA1 acetyl-CoA acyltransferase 1 -3.3985
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.39745
MSMO1 methylsterol monooxygenase 1 -3.3342
S100A4 S100 calcium binding protein A4 -3.23005
HADH hydroxyacyl-CoA dehydrogenase -3.15052
NAP1L4 nucleosome assembly protein 1-like 4 -3.1285
ZW10 zw10 kinetochore protein -3.12645
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -3.11575
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.0882
DTYMK deoxythymidylate kinase (thymidylate kinase) -3.08545
DDB2 damage-specific DNA binding protein 2, 48kDa -3.0602
TMEM97 transmembrane protein 97 -3.0343
ICAM3 intercellular adhesion molecule 3 -2.97995
CCNF cyclin F -2.9577
PGM1 phosphoglucomutase 1 -2.9376
SCGB1D1 secretoglobin, family 1D, member 1 -2.89762
AMDHD2 amidohydrolase domain containing 2 -2.8388
MRPL17 mitochondrial ribosomal protein L17 -2.83505
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -2.82297
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.82245
PPY pancreatic polypeptide -2.79562
CHEK2 checkpoint kinase 2 -2.78783
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -2.73025
OXA1L oxidase (cytochrome c) assembly 1-like -2.7237
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.7199
CRELD2 cysteine-rich with EGF-like domains 2 -2.7123
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.7052
HSPA1A heat shock 70kDa protein 1A -2.69025
SPDEF SAM pointed domain containing ETS transcription factor -2.68272
COPS7A COP9 signalosome subunit 7A -2.66455
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.6548
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.6293
CARD8 caspase recruitment domain family, member 8 -2.60095
TMEM134 transmembrane protein 134 -2.59205
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.5639
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -2.53305
HAT1 histone acetyltransferase 1 -2.5279
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.52752
PXMP4 peroxisomal membrane protein 4, 24kDa -2.5256
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -2.52115
NUCB2 nucleobindin 2 -2.51215
TEDC2 tubulin epsilon and delta complex 2 -2.50955
ELOVL2 ELOVL fatty acid elongase 2 -2.48948
FHL2 four and a half LIM domains 2 -2.48885
DCK deoxycytidine kinase -2.48395
NRIP1 nuclear receptor interacting protein 1 -2.46975
MIS18A MIS18 kinetochore protein A -2.4631
FBXO5 F-box protein 5 -2.43055
ISOC1 isochorismatase domain containing 1 -2.39805
MLEC malectin -2.39678
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -2.39657
TROAP trophinin associated protein -2.3888
HMOX1 heme oxygenase 1 -2.3767
TRAIP TRAF interacting protein -2.37635
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.37125
TK1 thymidine kinase 1, soluble -2.36555
ZNF83 zinc finger protein 83 -2.3617
NLRP2B NLR family pyrin domain containing 2B -2.3597
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.35768
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.34002
MVD mevalonate (diphospho) decarboxylase -2.3173
UBE2C ubiquitin-conjugating enzyme E2C -2.30485
TUBA1C tubulin, alpha 1c -2.28043
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.26375
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -2.2554
NUP93 nucleoporin 93kDa -2.25405
ZDHHC6 zinc finger, DHHC-type containing 6 -2.24775
SHCBP1 SHC SH2-domain binding protein 1 -2.24
LBR lamin B receptor -2.2385
TUBA1B tubulin, alpha 1b -2.23785
TOP2A topoisomerase (DNA) II alpha 170kDa -2.23333
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.2325
GJA1 gap junction protein, alpha 1, 43kDa -2.2299
AURKA aurora kinase A -2.2274
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -2.22735
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.2214
NUP43 nucleoporin 43kDa -2.22065
NUP85 nucleoporin 85kDa -2.21855
RAB4B RAB4B, member RAS oncogene family -2.20855
PECR peroxisomal trans-2-enoyl-CoA reductase -2.20405
FANCG Fanconi anemia, complementation group G -2.1858
PTTG1 pituitary tumor-transforming 1 -2.17905
ERCC6L excision repair cross-complementation group 6-like -2.17355
PYCR3 pyrroline-5-carboxylate reductase 3 -2.1725
HNMT histamine N-methyltransferase -2.16547
TBC1D10C TBC1 domain family, member 10C -2.16535
PANK4 pantothenate kinase 4 -2.16255
ZNF274 zinc finger protein 274 -2.14185
MDH1 malate dehydrogenase 1, NAD (soluble) -2.13605
MAP9 microtubule-associated protein 9 -2.12645
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.11925
FEN1 flap structure-specific endonuclease 1 -2.11725
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.11635
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.115
ITPKB inositol-trisphosphate 3-kinase B -2.1148
AP4M1 adaptor-related protein complex 4, mu 1 subunit -2.0963
SPDL1 spindle apparatus coiled-coil protein 1 -2.09395
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -2.09375
FUCA1 fucosidase, alpha-L- 1, tissue -2.0899
TM7SF2 transmembrane 7 superfamily member 2 -2.0871
B3GAT3 beta-1,3-glucuronyltransferase 3 -2.08668
LRRC20 leucine rich repeat containing 20 -2.07325
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.07155
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.07125
GCAT glycine C-acetyltransferase -2.0705
HOXB13 homeobox B13 -2.0683
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.06761
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.0668
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.0653
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.0564
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.05335
RBM6 RNA binding motif protein 6 -2.05325
UBL5 ubiquitin-like 5 -2.0527
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.05055
KIF4A kinesin family member 4A -2.04835
SRSF7 serine/arginine-rich splicing factor 7 -2.0477
TSPAN31 tetraspanin 31 -2.03737
EMC3 ER membrane protein complex subunit 3 -2.01895
BEAN1 brain expressed, associated with NEDD4, 1 -2.01705
PGRMC1 progesterone receptor membrane component 1 -2.0162
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0079
RMI1 RecQ mediated genome instability 1 -2.0077