CRCGN008_HEPG2_24H:G02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetracycline 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

207 genes differentially expressed following the CRCGN008_HEPG2_24H:G02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BACE2 beta-site APP-cleaving enzyme 2 10.0
TRIB3 tribbles pseudokinase 3 6.7978
DDIT4 DNA-damage-inducible transcript 4 6.3422
JADE2 jade family PHD finger 2 6.27598
CNPY3 canopy FGF signaling regulator 3 5.66105
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.4917
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.4476
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.30455
ADGRE5 adhesion G protein-coupled receptor E5 5.2929
RPL39L ribosomal protein L39-like 5.0533
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.93125
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.79255
NOSIP nitric oxide synthase interacting protein 4.6984
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.6495
EPHB2 EPH receptor B2 4.42403
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.3374
PHGDH phosphoglycerate dehydrogenase 4.2437
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 4.11175
IGFBP3 insulin-like growth factor binding protein 3 4.11065
STK10 serine/threonine kinase 10 4.10837
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 4.0966
MAP7 microtubule-associated protein 7 4.07017
LCN2 lipocalin 2 4.01665
SSBP2 single-stranded DNA binding protein 2 3.79808
AARS1 alanyl-tRNA synthetase 1 3.796
ABHD6 abhydrolase domain containing 6 3.78902
LOC122526780 uncharacterized LOC122526780 3.77755
CCP110 centriolar coiled coil protein 110kDa 3.77545
CCL2 chemokine (C-C motif) ligand 2 3.7699
CDC45 cell division cycle 45 3.69975
INPP1 inositol polyphosphate-1-phosphatase 3.5718
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.4396
RRAGA Ras-related GTP binding A 3.34085
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 3.2375
MINDY1 MINDY lysine 48 deubiquitinase 1 3.17655
TXNRD1 thioredoxin reductase 1 3.17325
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.17
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.10337
CYB561 cytochrome b561 3.02522
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.9842
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.94905
PYCR1 pyrroline-5-carboxylate reductase 1 2.8477
SARS1 seryl-tRNA synthetase 1 2.72215
NMU neuromedin U 2.7046
RBM15B RNA binding motif protein 15B 2.6569
PLEKHA5 pleckstrin homology domain containing, family A member 5 2.64535
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.54425
PARP2 poly (ADP-ribose) polymerase 2 2.54385
GARS1 glycyl-tRNA synthetase 1 2.4935
CAPN1 calpain 1, (mu/I) large subunit 2.44355
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.44187
TGFBI transforming growth factor, beta-induced, 68kDa 2.4208
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.3768
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.3607
GTF2IRD1 GTF2I repeat domain containing 1 2.35345
VGLL4 vestigial-like family member 4 2.34973
PCSK7 proprotein convertase subtilisin/kexin type 7 2.3018
AARSD1 alanyl-tRNA synthetase domain containing 1 2.2879
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2.2665
ADGRG1 adhesion G protein-coupled receptor G1 2.25898
COL16A1 collagen, type XVI, alpha 1 2.22965
SNAP29 synaptosomal-associated protein, 29kDa 2.2159
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.2103
SFTPB surfactant protein B 2.2089
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.18725
TSC22D3 TSC22 domain family, member 3 2.1778
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.1764
RASIP1 Ras interacting protein 1 2.15375
YARS1 tyrosyl-tRNA synthetase 1 2.13585
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.11915
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.1065
ZMIZ1 zinc finger, MIZ-type containing 1 2.10415
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.10285
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.0962
IGF2R insulin-like growth factor 2 receptor 2.08792
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.08068
ASS1 argininosuccinate synthase 1 2.0735
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.04205
SPINK4 serine peptidase inhibitor, Kazal type 4 2.0381
DCTN1 dynactin 1 2.03035
DSG2 desmoglein 2 2.01545
GADD45B growth arrest and DNA-damage-inducible, beta 2.01142
TRIB1 tribbles pseudokinase 1 2.00005
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.00002

decreased expression

Symbol Name Standardized Value
TCTN1 tectonic family member 1 -6.67855
PCNA proliferating cell nuclear antigen -6.07025
CCNB1 cyclin B1 -5.99795
ALDOC aldolase C, fructose-bisphosphate -5.89575
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.8143
SMNDC1 survival motor neuron domain containing 1 -5.18765
LDHD lactate dehydrogenase D -5.12785
CDK1 cyclin-dependent kinase 1 -5.08762
ZNF586 zinc finger protein 586 -5.06675
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.8562
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -4.70045
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.57798
SLC35F2 solute carrier family 35, member F2 -4.4858
FGFR4 fibroblast growth factor receptor 4 -4.37733
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.3755
FASTKD5 FAST kinase domains 5 -3.98795
CDC20 cell division cycle 20 -3.7892
CAB39 calcium binding protein 39 -3.58065
SOAT2 sterol O-acyltransferase 2 -3.5205
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.47235
CDC25B cell division cycle 25B -3.45485
CHIC2 cysteine-rich hydrophobic domain 2 -3.3682
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.28718
PRR7 proline rich 7 (synaptic) -3.22245
PGAM4 phosphoglycerate mutase family member 4 -3.18995
DCK deoxycytidine kinase -3.1353
REEP5 receptor accessory protein 5 -2.9126
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.90535
MAPK13 mitogen-activated protein kinase 13 -2.8982
ZNF606 zinc finger protein 606 -2.8859
FHL2 four and a half LIM domains 2 -2.86075
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -2.7683
MCM10 minichromosome maintenance complex component 10 -2.7314
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.6925
AK4 adenylate kinase 4 -2.61753
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.60745
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.5848
TERT telomerase reverse transcriptase -2.52725
PDLIM1 PDZ and LIM domain 1 -2.519
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I -2.49325
BIRC5 baculoviral IAP repeat containing 5 -2.48968
NRIP1 nuclear receptor interacting protein 1 -2.48518
HTN1 histatin 1 -2.4822
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.4813
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.4739
MELK maternal embryonic leucine zipper kinase -2.40395
PSRC1 proline/serine-rich coiled-coil 1 -2.40035
CCNA2 cyclin A2 -2.396
CRYGB crystallin, gamma B -2.37475
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.37335
BLTP3B bridge-like lipid transfer protein family member 3B -2.3641
NLRP2B NLR family pyrin domain containing 2B -2.36115
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.33985
NEK11 NIMA-related kinase 11 -2.3329
CCNA1 cyclin A1 -2.3291
ZDHHC6 zinc finger, DHHC-type containing 6 -2.326
TMEM33 transmembrane protein 33 -2.3252
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -2.31015
RFPL3 ret finger protein-like 3 -2.3016
ZNF134 zinc finger protein 134 -2.29715
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 -2.27825
HNMT histamine N-methyltransferase -2.26847
TRIM6-TRIM34 TRIM6-TRIM34 readthrough -2.2665
TMEM9B TMEM9 domain family, member B -2.2571
SPDEF SAM pointed domain containing ETS transcription factor -2.24907
EPPK1 epiplakin 1 -2.24105
CD58 CD58 molecule -2.23535
PUF60 poly-U binding splicing factor 60KDa -2.23275
LAGE3 L antigen family, member 3 -2.23085
AKAP8 A kinase (PRKA) anchor protein 8 -2.21012
TDG thymine-DNA glycosylase -2.20375
NOL11 nucleolar protein 11 -2.1986
CHEK2 checkpoint kinase 2 -2.19195
FAM111A family with sequence similarity 111, member A -2.18795
IL33 interleukin 33 -2.18735
DNAH7 dynein, axonemal, heavy chain 7 -2.1873
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.1869
HAT1 histone acetyltransferase 1 -2.1795
BAG4 BCL2-associated athanogene 4 -2.1783
HTN3 histatin 3 -2.17155
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.17135
NME5 NME/NM23 family member 5 -2.1636
TOMM34 translocase of outer mitochondrial membrane 34 -2.15495
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.1532
DCSTAMP dendrocyte expressed seven transmembrane protein -2.1354
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.13437
ZNF274 zinc finger protein 274 -2.12955
CCDC9 coiled-coil domain containing 9 -2.1237
UEVLD UEV and lactate/malate dehyrogenase domains -2.12325
NCK2 NCK adaptor protein 2 -2.11695
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.11375
NUP93 nucleoporin 93kDa -2.11095
GDF7 growth differentiation factor 7 -2.11005
BLM Bloom syndrome, RecQ helicase-like -2.1089
HSPA1A heat shock 70kDa protein 1A -2.1077
COMMD10 COMM domain containing 10 -2.1071
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.10215
F13A1 coagulation factor XIII, A1 polypeptide -2.1011
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.09665
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.0884
PRSS23 protease, serine, 23 -2.08545
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.08477
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.0806
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 -2.0777
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 -2.0747
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.07135
RBM47 RNA binding motif protein 47 -2.06315
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.0618
CRIPT cysteine-rich PDZ-binding protein -2.06095
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -2.05912
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.0583
RECQL4 RecQ protein-like 4 -2.05585
ZNF7 zinc finger protein 7 -2.0439
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.04375
STMN1 stathmin 1 -2.04345
TMEM97 transmembrane protein 97 -2.04235
RPS5 ribosomal protein S5 -2.0369
KIFC1 kinesin family member C1 -2.03395
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.0328
NDP Norrie disease (pseudoglioma) -2.03095
UBE2C ubiquitin-conjugating enzyme E2C -2.03035
TOMM70 translocase of outer mitochondrial membrane 70 -2.02548
ZNF267 zinc finger protein 267 -2.02085