| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | tetracycline 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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95 genes differentially expressed following the CRCGN008_HEPG2_24H:G03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CHN1 | chimerin 1 | 7.36765 |
| DDIT4 | DNA-damage-inducible transcript 4 | 5.5905 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.1128 |
| TRIB3 | tribbles pseudokinase 3 | 5.00365 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 4.98695 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 4.92565 |
| E2F2 | E2F transcription factor 2 | 4.8812 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.79475 |
| MYLK | myosin light chain kinase | 4.70605 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 4.62855 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.47825 |
| CCNA1 | cyclin A1 | 4.43945 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 4.41385 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 4.3519 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 4.3115 |
| STIMATE | STIM activating enhancer | 4.19875 |
| PIH1D1 | PIH1 domain containing 1 | 4.1941 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.9166 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 3.82473 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 3.69505 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 3.5345 |
| PHGDH | phosphoglycerate dehydrogenase | 3.27838 |
| TRIM13 | tripartite motif containing 13 | 3.2019 |
| RRAGA | Ras-related GTP binding A | 3.16845 |
| AARS1 | alanyl-tRNA synthetase 1 | 2.9969 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.8527 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.7476 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.65548 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 2.61797 |
| SLC9A3 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 | 2.5639 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.5431 |
| TLR4 | toll-like receptor 4 | 2.53125 |
| CCNF | cyclin F | 2.48417 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 2.40425 |
| KIF20A | kinesin family member 20A | 2.39305 |
| SFTPB | surfactant protein B | 2.33832 |
| VCAM1 | vascular cell adhesion molecule 1 | 2.2664 |
| CDC45 | cell division cycle 45 | 2.2538 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.1818 |
| NECTIN2 | nectin cell adhesion molecule 2 | 2.16425 |
| PRR14L | proline rich 14-like | 2.1568 |
| BCL3 | B-cell CLL/lymphoma 3 | 2.0861 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.0824 |
| ZNF428 | zinc finger protein 428 | 2.06645 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 2.0103 |
| Symbol | Name | Standardized Value |
|---|---|---|
| OXA1L | oxidase (cytochrome c) assembly 1-like | -6.06385 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -5.4965 |
| TCTN1 | tectonic family member 1 | -4.64215 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.62225 |
| VAT1 | vesicle amine transport 1 | -4.6014 |
| LDHD | lactate dehydrogenase D | -4.49665 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -4.1667 |
| FASTKD5 | FAST kinase domains 5 | -4.1429 |
| TLCD3A | TLC domain containing 3A | -3.92145 |
| GPX3 | glutathione peroxidase 3 | -3.65707 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.63835 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -3.48823 |
| MTA1 | metastasis associated 1 | -3.3015 |
| CCNB2 | cyclin B2 | -3.14805 |
| AURKB | aurora kinase B | -2.99405 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.99185 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.90865 |
| SNX11 | sorting nexin 11 | -2.87873 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.7676 |
| NLRP2B | NLR family pyrin domain containing 2B | -2.7544 |
| TOMM70 | translocase of outer mitochondrial membrane 70 | -2.63597 |
| S100A4 | S100 calcium binding protein A4 | -2.62225 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -2.5448 |
| CDC25B | cell division cycle 25B | -2.53805 |
| RGS2 | regulator of G-protein signaling 2 | -2.5265 |
| SOAT2 | sterol O-acyltransferase 2 | -2.5047 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -2.429 |
| LOC124906748 | beta-defensin 4A | -2.341 |
| L1TD1 | LINE-1 type transposase domain containing 1 | -2.2822 |
| TTYH1 | tweety family member 1 | -2.272 |
| DPH2 | DPH2 homolog (S. cerevisiae) | -2.244 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -2.23065 |
| SNF8 | SNF8, ESCRT-II complex subunit | -2.23005 |
| PLK1 | polo-like kinase 1 | -2.22405 |
| PRPSAP2 | phosphoribosyl pyrophosphate synthetase-associated protein 2 | -2.22165 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -2.21365 |
| REEP5 | receptor accessory protein 5 | -2.17392 |
| S100A7 | S100 calcium binding protein A7 | -2.12285 |
| FBLN5 | fibulin 5 | -2.1104 |
| MATN2 | matrilin 2 | -2.09685 |
| CCDC85C | coiled-coil domain containing 85C | -2.0946 |
| ZFHX4 | zinc finger homeobox 4 | -2.0854 |
| TBC1D10C | TBC1 domain family, member 10C | -2.08385 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | -2.08015 |
| SLURP1 | secreted LY6/PLAUR domain containing 1 | -2.07185 |
| LAMA2 | laminin, alpha 2 | -2.0568 |
| PUF60 | poly-U binding splicing factor 60KDa | -2.0471 |
| ADA | adenosine deaminase | -2.0416 |
| PTGIR | prostaglandin I2 (prostacyclin) receptor (IP) | -2.0301 |
| AEN | apoptosis enhancing nuclease | -2.0151 |
