CRCGN008_HEPG2_24H:G05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetracycline 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN008_HEPG2_24H:G05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 10.0
ADRB2 adrenoceptor beta 2, surface 5.506
HLA-DMA major histocompatibility complex, class II, DM alpha 5.2284
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.0839
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.038
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.0332
UBQLN2 ubiquilin 2 5.03015
PPARG peroxisome proliferator-activated receptor gamma 4.7603
ARL4C ADP-ribosylation factor-like 4C 4.55017
LOC122526780 uncharacterized LOC122526780 4.4269
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.3484
CHEK2 checkpoint kinase 2 3.43805
RXYLT1 ribitol xylosyltransferase 1 3.2657
EGF epidermal growth factor 3.17425
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.11788
CDCA4 cell division cycle associated 4 3.0058
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.7832
KLHL9 kelch-like family member 9 2.7636
GATA2 GATA binding protein 2 2.74365
ZNF518A zinc finger protein 518A 2.72855
FPGS folylpolyglutamate synthase 2.51125
CHN1 chimerin 1 2.4207
CAPNS1 calpain, small subunit 1 2.3873
PLSCR1 phospholipid scramblase 1 2.36345
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.3607
ZNF589 zinc finger protein 589 2.33303
WASF3 WAS protein family, member 3 2.2975
GSTZ1 glutathione S-transferase zeta 1 2.2625
SNX7 sorting nexin 7 2.0824
MAGED1 melanoma antigen family D1 2.077
USP9X ubiquitin specific peptidase 9, X-linked 2.00335

decreased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 -6.32915
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.4102
CAB39 calcium binding protein 39 -5.2249
CHMP4B charged multivesicular body protein 4B -4.74578
LDHD lactate dehydrogenase D -4.7281
PCNA proliferating cell nuclear antigen -4.6007
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.4084
CCNB2 cyclin B2 -4.40045
TLCD3A TLC domain containing 3A -4.3896
NGRN neugrin, neurite outgrowth associated -4.3885
CD320 CD320 molecule -4.15555
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.14045
RNF167 ring finger protein 167 -3.09315
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.99525
OXA1L oxidase (cytochrome c) assembly 1-like -2.83415
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.7281
NRIP1 nuclear receptor interacting protein 1 -2.5093
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.50415
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.38245
BFSP2 beaded filament structural protein 2, phakinin -2.2885
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.27635
NVL nuclear VCP-like -2.2585
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.22965
RBM34 RNA binding motif protein 34 -2.19475
CCP110 centriolar coiled coil protein 110kDa -2.1927
AARSD1 alanyl-tRNA synthetase domain containing 1 -2.1924
TOMM70 translocase of outer mitochondrial membrane 70 -2.14942
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -2.13225
CCL24 chemokine (C-C motif) ligand 24 -2.1139
LGALS4 lectin, galactoside-binding, soluble, 4 -2.1093
KRT33A keratin 33A, type I -2.1025
TACR3 tachykinin receptor 3 -2.0999
SLC25A44 solute carrier family 25, member 44 -2.09963
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.09825
H2BC6 H2B clustered histone 6 -2.0982
FLG filaggrin -2.0725
INCENP inner centromere protein antigens 135/155kDa -2.0521
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.0294
ZIC4 Zic family member 4 -2.02425
ECEL1 endothelin converting enzyme-like 1 -2.01615
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) -2.0098
CENPM centromere protein M -2.0024
BMX BMX non-receptor tyrosine kinase -2.00005