CRCGN008_HEPG2_24H:G06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetracycline 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN008_HEPG2_24H:G06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 7.21665
TIAM1 T-cell lymphoma invasion and metastasis 1 6.72275
HLA-DMA major histocompatibility complex, class II, DM alpha 5.29115
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.25095
ADRB2 adrenoceptor beta 2, surface 5.01705
ATP11B ATPase, class VI, type 11B 4.85825
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.1976
CHN1 chimerin 1 3.9794
EGF epidermal growth factor 3.84885
GPER1 G protein-coupled estrogen receptor 1 3.83703
EVL Enah/Vasp-like 3.6795
CYCS cytochrome c, somatic 3.26655
CCNF cyclin F 3.08235
UBE2A ubiquitin-conjugating enzyme E2A 2.92945
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.5762
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.4647
SSBP2 single-stranded DNA binding protein 2 2.4647
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 2.447
PLSCR3 phospholipid scramblase 3 2.34808
LCN2 lipocalin 2 2.3462
H2BC12 H2B clustered histone 12 2.31843
CTSH cathepsin H 2.271
AHR aryl hydrocarbon receptor 2.2453
EGFL6 EGF-like-domain, multiple 6 2.23685
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.2212
ZNF589 zinc finger protein 589 2.19968
ICOS inducible T-cell co-stimulator 2.1962
LOC122526780 uncharacterized LOC122526780 2.1775
SETD6 SET domain containing 6 2.1585
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.13912
CD4 CD4 molecule 2.1295
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.12755
TBCB tubulin folding cofactor B 2.11215
TNIP1 TNFAIP3 interacting protein 1 2.0893
GORASP1 golgi reassembly stacking protein 1, 65kDa 2.085
GPATCH8 G patch domain containing 8 2.06243
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.04783
DCTN4 dynactin 4 (p62) 2.0208

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.55345
OXA1L oxidase (cytochrome c) assembly 1-like -6.52195
DNM1L dynamin 1-like -5.0661
ADI1 acireductone dioxygenase 1 -5.0504
HAT1 histone acetyltransferase 1 -4.9832
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.95025
NRIP1 nuclear receptor interacting protein 1 -4.79542
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.77325
CDC20 cell division cycle 20 -4.6933
PECR peroxisomal trans-2-enoyl-CoA reductase -4.6623
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.64025
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.62445
CAB39 calcium binding protein 39 -4.6149
PRPF4 pre-mRNA processing factor 4 -3.7719
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.33858
SCAND1 SCAN domain containing 1 -3.032
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.80335
WASHC4 WASH complex subunit 4 -2.781
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.69407
ZMIZ1 zinc finger, MIZ-type containing 1 -2.5578
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.54405
RBM15B RNA binding motif protein 15B -2.47865
SNX11 sorting nexin 11 -2.45092
RNF167 ring finger protein 167 -2.3392
HSPA8 heat shock 70kDa protein 8 -2.3332
MEP1B meprin A, beta -2.31785
EXT1 exostosin glycosyltransferase 1 -2.29225
DGKD diacylglycerol kinase, delta 130kDa -2.25255
CTBP2 C-terminal binding protein 2 -2.20735
F2RL1 coagulation factor II (thrombin) receptor-like 1 -2.1544
RHOB ras homolog family member B -2.15175
MED9 mediator complex subunit 9 -2.1441
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 -2.13635
ALPK1 alpha-kinase 1 -2.13605
ECEL1 endothelin converting enzyme-like 1 -2.1335
MCAM melanoma cell adhesion molecule -2.12065
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -2.10465
EPHA4 EPH receptor A4 -2.0949
CHEK1 checkpoint kinase 1 -2.08363
LGALS1 lectin, galactoside-binding, soluble, 1 -2.08265
PRDM4 PR domain containing 4 -2.07678
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.07435
VPREB3 pre-B lymphocyte 3 -2.0513
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 -2.04365
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.0344
SH3BP4 SH3-domain binding protein 4 -2.02775
PCDHGA8 protocadherin gamma subfamily A, 8 -2.02035
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -2.01795