CRCGN008_HEPG2_24H:G07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methoxychlor 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

217 genes differentially expressed following the CRCGN008_HEPG2_24H:G07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 10.0
AMDHD2 amidohydrolase domain containing 2 6.5501
UBQLN2 ubiquilin 2 5.39575
INPP1 inositol polyphosphate-1-phosphatase 5.2822
RPP38 ribonuclease P/MRP 38kDa subunit 5.05515
EPHB2 EPH receptor B2 4.79025
INTS3 integrator complex subunit 3 4.78955
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.70265
EVL Enah/Vasp-like 4.60555
RRAGA Ras-related GTP binding A 4.415
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.4094
AARS1 alanyl-tRNA synthetase 1 4.2629
MVP major vault protein 4.23355
SQSTM1 sequestosome 1 4.21892
CNPY3 canopy FGF signaling regulator 3 4.14625
GRWD1 glutamate-rich WD repeat containing 1 4.13745
CDCA4 cell division cycle associated 4 4.105
VAT1 vesicle amine transport 1 4.0932
CCP110 centriolar coiled coil protein 110kDa 4.0005
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.92385
GRB10 growth factor receptor-bound protein 10 3.86512
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.78865
SNX7 sorting nexin 7 3.70705
GPER1 G protein-coupled estrogen receptor 1 3.58995
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.47155
TIMP2 TIMP metallopeptidase inhibitor 2 3.3351
SQOR sulfide quinone oxidoreductase 3.32285
MMP1 matrix metallopeptidase 1 3.31205
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.24627
GATA2 GATA binding protein 2 3.1962
ADGRG1 adhesion G protein-coupled receptor G1 3.17958
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 3.08667
MAP7 microtubule-associated protein 7 2.99572
KIFBP kinesin family binding protein 2.9911
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.9578
MICALL1 MICAL-like 1 2.95703
PKN1 protein kinase N1 2.87278
DDIT4 DNA-damage-inducible transcript 4 2.87195
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.85965
TMEM184B transmembrane protein 184B 2.76475
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.74845
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.6889
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.6824
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.6156
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.59753
GAA glucosidase, alpha; acid 2.5623
GLRX glutaredoxin (thioltransferase) 2.51455
CLTA clathrin, light chain A 2.46745
VAC14 Vac14 homolog (S. cerevisiae) 2.45215
NANOS3 nanos homolog 3 (Drosophila) 2.4361
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.4335
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.43255
ERCC5 excision repair cross-complementation group 5 2.41395
SLC35F2 solute carrier family 35, member F2 2.41135
SKIC2 SKI2 subunit of superkiller complex 2.3693
ACOT9 acyl-CoA thioesterase 9 2.34095
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.3361
ZFP36 ZFP36 ring finger protein 2.3288
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.29553
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.285
EVA1B eva-1 homolog B (C. elegans) 2.25763
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.24465
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.23875
RFK riboflavin kinase 2.23003
WASF3 WAS protein family, member 3 2.2289
SYNJ2BP synaptojanin 2 binding protein 2.22615
ARHGAP10 Rho GTPase activating protein 10 2.18895
UGDH UDP-glucose 6-dehydrogenase 2.1888
ATOX1 antioxidant 1 copper chaperone 2.18765
ARHGAP22 Rho GTPase activating protein 22 2.17715
MPV17L-BMERB1 MPV17L-BMERB1 readthrough 2.1401
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.13147
IL4R interleukin 4 receptor 2.12945
TERF2IP telomeric repeat binding factor 2, interacting protein 2.1274
EDF1 endothelial differentiation-related factor 1 2.1221
PCGF2 polycomb group ring finger 2 2.12094
CTTN cortactin 2.10373
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough 2.09315
ITFG1 integrin alpha FG-GAP repeat containing 1 2.07955
PPARG peroxisome proliferator-activated receptor gamma 2.0779
IGF2R insulin-like growth factor 2 receptor 2.07535
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.0734
DOCK1 dedicator of cytokinesis 1 2.06615
ALAS1 5'-aminolevulinate synthase 1 2.0638
SPATA20 spermatogenesis associated 20 2.05985
SLC44A1 solute carrier family 44 (choline transporter), member 1 2.0489
TBC1D3G TBC1 domain family member 3G 2.04595
PRKCD protein kinase C, delta 2.03425
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.0312
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.02135
FBXO7 F-box protein 7 2.0162
PPP1R26 protein phosphatase 1, regulatory subunit 26 2.0146
BAG3 BCL2-associated athanogene 3 2.01265
CUEDC2 CUE domain containing 2 2.0019

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -8.0953
AURKB aurora kinase B -7.27185
CDK1 cyclin-dependent kinase 1 -6.69953
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.097
PLK1 polo-like kinase 1 -6.0298
CCNB1 cyclin B1 -5.76125
ADI1 acireductone dioxygenase 1 -5.6979
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.6431
PSRC1 proline/serine-rich coiled-coil 1 -5.6096
BIRC5 baculoviral IAP repeat containing 5 -4.908
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.8801
CCNB2 cyclin B2 -4.84785
LDHD lactate dehydrogenase D -4.82795
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -4.80305
UBE2C ubiquitin-conjugating enzyme E2C -4.76765
CCNA2 cyclin A2 -4.73908
RFC2 replication factor C (activator 1) 2, 40kDa -4.71158
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.69415
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.5335
ICAM3 intercellular adhesion molecule 3 -4.3637
ZMIZ1 zinc finger, MIZ-type containing 1 -4.29565
ZNF586 zinc finger protein 586 -4.2195
TOP2A topoisomerase (DNA) II alpha 170kDa -4.12705
RNASE7 ribonuclease, RNase A family, 7 -4.12512
FASTKD5 FAST kinase domains 5 -3.9627
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.94495
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.85818
HAT1 histone acetyltransferase 1 -3.8236
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.7863
LOC124907782 dual specificity protein phosphatase 22 -3.7784
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.7772
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.72655
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.7013
ELAC2 elaC ribonuclease Z 2 -3.4563
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.3681
NT5DC2 5'-nucleotidase domain containing 2 -3.36395
CDC25B cell division cycle 25B -3.2951
STMN1 stathmin 1 -3.17495
CDC6 cell division cycle 6 -3.1418
LBR lamin B receptor -3.1308
OIP5 Opa interacting protein 5 -3.0471
ASF1B anti-silencing function 1B histone chaperone -3.00405
TK1 thymidine kinase 1, soluble -2.9955
DCK deoxycytidine kinase -2.9845
NUP85 nucleoporin 85kDa -2.93145
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.90195
CDCA8 cell division cycle associated 8 -2.8136
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.8126
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.7947
TFDP1 transcription factor Dp-1 -2.78198
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.7078
DERA deoxyribose-phosphate aldolase (putative) -2.654
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.6375
UBE2S ubiquitin-conjugating enzyme E2S -2.6307
NCAPD2 non-SMC condensin I complex, subunit D2 -2.60525
KIF11 kinesin family member 11 -2.5908
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.58255
DDB2 damage-specific DNA binding protein 2, 48kDa -2.5798
ERCC6L excision repair cross-complementation group 6-like -2.56695
FBXO5 F-box protein 5 -2.55285
SCAND1 SCAN domain containing 1 -2.535
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.52785
MAPK13 mitogen-activated protein kinase 13 -2.50913
RFC3 replication factor C (activator 1) 3, 38kDa -2.5006
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.4557
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.4221
TRIB3 tribbles pseudokinase 3 -2.4166
LUM lumican -2.41335
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.39835
DSCC1 DNA replication and sister chromatid cohesion 1 -2.3669
GTF2A2 general transcription factor IIA, 2, 12kDa -2.3554
PBK PDZ binding kinase -2.34485
RFWD3 ring finger and WD repeat domain 3 -2.3371
NRIP1 nuclear receptor interacting protein 1 -2.3359
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.3192
MYCBP MYC binding protein -2.3033
NCAPH non-SMC condensin I complex, subunit H -2.28585
ZNF274 zinc finger protein 274 -2.2685
STIL SCL/TAL1 interrupting locus -2.2652
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.2628
CLCA2 chloride channel accessory 2 -2.26047
KIF4A kinesin family member 4A -2.2507
CDCA3 cell division cycle associated 3 -2.24895
HADH hydroxyacyl-CoA dehydrogenase -2.24885
LHFPL6 LHFPL tetraspan subfamily member 6 -2.2437
TRIM58 tripartite motif containing 58 -2.22875
UNC50 unc-50 homolog (C. elegans) -2.22545
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -2.22053
DBF4 DBF4 zinc finger -2.1923
DLK2 delta-like 2 homolog (Drosophila) -2.19
WASHC4 WASH complex subunit 4 -2.18453
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.1736
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.16885
UBE2M ubiquitin-conjugating enzyme E2M -2.158
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.1425
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.13955
CENPA centromere protein A -2.1372
RBM38 RNA binding motif protein 38 -2.12935
MIA melanoma inhibitory activity -2.128
AURKA aurora kinase A -2.1224
FXYD3 FXYD domain containing ion transport regulator 3 -2.10752
NEMP1 nuclear envelope integral membrane protein 1 -2.10588
TROAP trophinin associated protein -2.1047
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.0979
TXNDC9 thioredoxin domain containing 9 -2.09153
COL3A1 collagen, type III, alpha 1 -2.08755
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.0784
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -2.07323
CD5L CD5 molecule-like -2.07305
DCN decorin -2.06591
CCNC cyclin C -2.06365
RFC4 replication factor C (activator 1) 4, 37kDa -2.0487
SETD1B SET domain containing 1B -2.0469
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.0444
SPDL1 spindle apparatus coiled-coil protein 1 -2.0335
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -2.0321
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.03162
ZNF587 zinc finger protein 587 -2.0209
ZNF304 zinc finger protein 304 -2.02025
RAB5IF RAB5 interacting factor -2.0149
NUP37 nucleoporin 37kDa -2.0072
ECT2 epithelial cell transforming 2 -2.0052
SPC25 SPC25, NDC80 kinetochore complex component -2.0