CRCGN008_HEPG2_24H:G08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methoxychlor 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN008_HEPG2_24H:G08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.43495
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.3596
HLA-DMA major histocompatibility complex, class II, DM alpha 4.93465
DYNLT3 dynein, light chain, Tctex-type 3 4.66125
SNAP25 synaptosomal-associated protein, 25kDa 4.3852
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.18295
RRAGA Ras-related GTP binding A 3.855
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.7793
BIRC2 baculoviral IAP repeat containing 2 3.7532
NMU neuromedin U 3.50315
CDPF1 cysteine-rich, DPF motif domain containing 1 3.3542
CEP57 centrosomal protein 57kDa 3.20283
TIAM1 T-cell lymphoma invasion and metastasis 1 3.1429
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.00438
HLA-DRA major histocompatibility complex, class II, DR alpha 2.98467
USP6NL USP6 N-terminal like 2.66005
VGLL4 vestigial-like family member 4 2.56783
GPATCH8 G patch domain containing 8 2.53755
CHN1 chimerin 1 2.5287
RALGDS ral guanine nucleotide dissociation stimulator 2.35725
STXBP2 syntaxin binding protein 2 2.32785
ARID4B AT rich interactive domain 4B (RBP1-like) 2.3137
HEBP1 heme binding protein 1 2.30635
SKIC2 SKI2 subunit of superkiller complex 2.276
ZBTB35 zinc finger and BTB domain containing 35 2.21892
KAT6A K(lysine) acetyltransferase 6A 2.08652

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.1412
EGF epidermal growth factor -5.5372
LDHD lactate dehydrogenase D -5.2087
NGRN neugrin, neurite outgrowth associated -5.0826
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0166
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.87625
LOC124907782 dual specificity protein phosphatase 22 -4.72445
CHMP4B charged multivesicular body protein 4B -4.60293
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -4.51795
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -4.17295
CAB39 calcium binding protein 39 -3.7916
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.77175
SPAG4 sperm associated antigen 4 -3.32795
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.11715
WASHC4 WASH complex subunit 4 -3.10107
ZW10 zw10 kinetochore protein -2.89585
HMG20B high mobility group 20B -2.87707
CD58 CD58 molecule -2.58343
CCDC198 coiled-coil domain containing 198 -2.56945
DERA deoxyribose-phosphate aldolase (putative) -2.4866
ACAA1 acetyl-CoA acyltransferase 1 -2.33438
RORB RAR-related orphan receptor B -2.32335
NRIP1 nuclear receptor interacting protein 1 -2.2725
WDR76 WD repeat domain 76 -2.20555
SCAND1 SCAN domain containing 1 -2.14845
DDB2 damage-specific DNA binding protein 2, 48kDa -2.1287
FRK fyn-related Src family tyrosine kinase -2.12195
CCDC69 coiled-coil domain containing 69 -2.1021
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.09405
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 -2.05045
NOD2 nucleotide-binding oligomerization domain containing 2 -2.0479
ZBTB6 zinc finger and BTB domain containing 6 -2.01815