CRCGN008_HEPG2_24H:G11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methoxychlor 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

175 genes differentially expressed following the CRCGN008_HEPG2_24H:G11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 5.5955
UBQLN2 ubiquilin 2 5.4087
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.34705
MOK MOK protein kinase 5.24035
MSRA methionine sulfoxide reductase A 4.9013
NANOS3 nanos homolog 3 (Drosophila) 4.83915
CBR3 carbonyl reductase 3 4.83305
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.8003
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.65105
MYLK myosin light chain kinase 4.4672
KIFBP kinesin family binding protein 4.31835
PRR15L proline rich 15-like 4.10535
SSBP2 single-stranded DNA binding protein 2 3.995
NMU neuromedin U 3.94075
PLSCR1 phospholipid scramblase 1 3.89665
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.89205
VGLL4 vestigial-like family member 4 3.76795
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.7257
SOCS2 suppressor of cytokine signaling 2 3.6192
PFKL phosphofructokinase, liver 3.50613
TIAM1 T-cell lymphoma invasion and metastasis 1 3.46007
CYCS cytochrome c, somatic 3.32515
KDM5A lysine (K)-specific demethylase 5A 3.23772
CHN1 chimerin 1 3.19255
DHDDS dehydrodolichyl diphosphate synthase 3.12105
MAP7 microtubule-associated protein 7 3.01853
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.01635
MMP1 matrix metallopeptidase 1 2.94003
GSTZ1 glutathione S-transferase zeta 1 2.93015
HLA-DRA major histocompatibility complex, class II, DR alpha 2.89318
BPHL biphenyl hydrolase-like (serine hydrolase) 2.82975
GATD3 glutamine amidotransferase class 1 domain containing 3 2.8163
PRPF18 pre-mRNA processing factor 18 2.7729
TASOR2 transcription activation suppressor family member 2 2.76955
CDC45 cell division cycle 45 2.70655
BOLA1 bolA family member 1 2.6822
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.6494
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.6387
RNF115 ring finger protein 115 2.60625
KIF20A kinesin family member 20A 2.6038
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.59695
SEPHS1 selenophosphate synthetase 1 2.55862
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.51165
NAMPT nicotinamide phosphoribosyltransferase 2.48825
BIN3 bridging integrator 3 2.4678
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.46565
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 2.46355
TMEM164 transmembrane protein 164 2.46005
PRKCD protein kinase C, delta 2.4553
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.44425
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.43985
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.4363
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.42425
TENM3 teneurin transmembrane protein 3 2.4238
SCHIP1 schwannomin interacting protein 1 2.4115
CDCA4 cell division cycle associated 4 2.39285
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.38812
GSK3B glycogen synthase kinase 3 beta 2.38535
SLC75A1 solute carrier family 75 member 1 2.3756
RPA3 replication protein A3, 14kDa 2.3632
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.35363
HSPA14 heat shock 70kDa protein 14 2.3411
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.31695
PCDHB3 protocadherin beta 3 2.2972
RNF38 ring finger protein 38 2.29465
TMEM158 transmembrane protein 158 (gene/pseudogene) 2.23535
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.23285
FPGS folylpolyglutamate synthase 2.2038
GATA2 GATA binding protein 2 2.186
NOSIP nitric oxide synthase interacting protein 2.1756
MTCH1 mitochondrial carrier 1 2.1711
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.16305
EVL Enah/Vasp-like 2.1524
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.1421
GRWD1 glutamate-rich WD repeat containing 1 2.1415
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.14075
UBE2E1 ubiquitin-conjugating enzyme E2E 1 2.13035
NPR2 natriuretic peptide receptor 2 2.12195
HAPSTR1 HUWE1 associated protein modifying stress responses 2.11695
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 2.10185
SRGN serglycin 2.09015
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 2.0849
TMEM14A transmembrane protein 14A 2.0767
MED28 mediator complex subunit 28 2.06945
DUSP3 dual specificity phosphatase 3 2.06282
KLHL9 kelch-like family member 9 2.05685
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.05575
ZNF267 zinc finger protein 267 2.0451
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.0437
ZC2HC1A zinc finger, C2HC-type containing 1A 2.0427
UPB1 ureidopropionase, beta 2.0388
FNBP1L formin binding protein 1-like 2.03615
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.026
TMUB2 transmembrane and ubiquitin-like domain containing 2 2.0247
NADSYN1 NAD synthetase 1 2.01815
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.0131
CLEC7A C-type lectin domain family 7, member A 2.00695
ACSM2A acyl-CoA synthetase medium-chain family member 2A 2.00405
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.0038
CBX6 chromobox homolog 6 2.0019

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
PCNA proliferating cell nuclear antigen -10.0
CCNB2 cyclin B2 -8.37735
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.64015
TRIB3 tribbles pseudokinase 3 -5.14695
CD320 CD320 molecule -5.1003
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.8987
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.88155
CHMP4B charged multivesicular body protein 4B -4.76517
PECR peroxisomal trans-2-enoyl-CoA reductase -4.53765
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.30085
HLA-DMA major histocompatibility complex, class II, DM alpha -4.221
MTFR1 mitochondrial fission regulator 1 -4.04717
VDAC1 voltage-dependent anion channel 1 -3.84907
GNAS GNAS complex locus -3.5606
OXA1L oxidase (cytochrome c) assembly 1-like -3.32245
PRPF4 pre-mRNA processing factor 4 -3.3066
MACF1 microtubule-actin crosslinking factor 1 -3.28463
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.27242
FHL2 four and a half LIM domains 2 -3.26425
HSPA8 heat shock 70kDa protein 8 -3.17892
LOC124907782 dual specificity protein phosphatase 22 -2.9468
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.9165
CUL1 cullin 1 -2.80105
S100G S100 calcium binding protein G -2.78975
MAPK13 mitogen-activated protein kinase 13 -2.76925
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.76496
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -2.76113
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.69295
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.692
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.61715
CD58 CD58 molecule -2.61553
RFX7 regulatory factor X, 7 -2.6013
CCNB1 cyclin B1 -2.54285
GDE1 glycerophosphodiester phosphodiesterase 1 -2.5427
ARHGAP25 Rho GTPase activating protein 25 -2.49923
S100PBP S100P binding protein -2.48495
RPS8 ribosomal protein S8 -2.44485
RPL4 ribosomal protein L4 -2.38932
PWP1 PWP1 homolog (S. cerevisiae) -2.38105
ZNF507 zinc finger protein 507 -2.3704
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa -2.3669
NR0B2 nuclear receptor subfamily 0, group B, member 2 -2.36645
AMIGO2 adhesion molecule with Ig-like domain 2 -2.34425
MXRA7 matrix-remodelling associated 7 -2.30515
ZFYVE26 zinc finger, FYVE domain containing 26 -2.29985
TBKBP1 TBK1 binding protein 1 -2.2934
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.23435
NCALD neurocalcin delta -2.22905
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.21045
ZMYM6 zinc finger, MYM-type 6 -2.1903
HRC histidine rich calcium binding protein -2.1842
MYOM1 myomesin 1 -2.16085
OGN osteoglycin -2.1425
ZW10 zw10 kinetochore protein -2.1185
NVL nuclear VCP-like -2.1101
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.1088
OR1D2 olfactory receptor, family 1, subfamily D, member 2 -2.09905
OTUD3 OTU deubiquitinase 3 -2.09655
DCPS decapping enzyme, scavenger -2.0945
TGFA transforming growth factor, alpha -2.08885
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.06665
SP4 Sp4 transcription factor -2.05605
SSRP1 structure specific recognition protein 1 -2.0484
MOSPD1 motile sperm domain containing 1 -2.04415
SMYD2 SET and MYND domain containing 2 -2.042
CCR9 chemokine (C-C motif) receptor 9 -2.03475
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -2.03465
LOC102723713 TP53-target gene 3 protein -2.0236
CEP41 centrosomal protein 41kDa -2.01815
AIDA axin interactor, dorsalization associated -2.0152
WDR26 WD repeat domain 26 -2.0128
NPC1L1 NPC1-like 1 -2.00355
ZNF514 zinc finger protein 514 -2.00275
DENR density-regulated protein -2.0018