| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | withaferin-a 0.62 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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111 genes differentially expressed following the CRCGN008_HEPG2_24H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 6.32615 |
| SQOR | sulfide quinone oxidoreductase | 5.39655 |
| TXNRD1 | thioredoxin reductase 1 | 5.38225 |
| AMDHD2 | amidohydrolase domain containing 2 | 5.34405 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 5.2665 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 5.20595 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 5.15595 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 4.96105 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.7595 |
| INTS3 | integrator complex subunit 3 | 4.576 |
| UGDH | UDP-glucose 6-dehydrogenase | 4.45655 |
| MYLK | myosin light chain kinase | 4.41735 |
| CDCA4 | cell division cycle associated 4 | 4.3938 |
| ABHD4 | abhydrolase domain containing 4 | 4.21635 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.8426 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 3.76355 |
| HSPA1A | heat shock 70kDa protein 1A | 3.62405 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 3.33295 |
| CYCS | cytochrome c, somatic | 3.2855 |
| TXNL4B | thioredoxin-like 4B | 3.2576 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 3.2368 |
| EVL | Enah/Vasp-like | 3.07635 |
| H2BC12 | H2B clustered histone 12 | 2.931 |
| SQSTM1 | sequestosome 1 | 2.80963 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 2.6745 |
| LYPLA1-TCEA1 | LYPLA1-TCEA1 readthrough | 2.66945 |
| TMEM109 | transmembrane protein 109 | 2.6369 |
| TBPL1 | TBP-like 1 | 2.56775 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 2.53035 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.4558 |
| TATDN2 | TatD DNase domain containing 2 | 2.378 |
| ZMPSTE24 | zinc metallopeptidase STE24 | 2.35835 |
| RASAL2 | RAS protein activator like 2 | 2.3035 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 2.29285 |
| BAD | BCL2-associated agonist of cell death | 2.28197 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 2.2525 |
| QTRT1 | queuine tRNA-ribosyltransferase 1 | 2.23885 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 2.23257 |
| HMOX1 | heme oxygenase 1 | 2.209 |
| TMEM50A | transmembrane protein 50A | 2.19175 |
| FOSL1 | FOS-like antigen 1 | 2.1871 |
| NOP14 | NOP14 nucleolar protein | 2.17765 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.1731 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.1413 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 2.14 |
| SAFB | scaffold attachment factor B | 2.11548 |
| PSMA1 | proteasome (prosome, macropain) subunit, alpha type, 1 | 2.11545 |
| LUC7L | LUC7-like (S. cerevisiae) | 2.08545 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.07935 |
| BARX1 | BARX homeobox 1 | 2.02895 |
| NUP98 | nucleoporin 98kDa | 2.0213 |
| PLSCR3 | phospholipid scramblase 3 | 2.01813 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 2.00865 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 2.00645 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | -10.0 |
| CCNB2 | cyclin B2 | -8.95635 |
| C5 | complement component 5 | -5.51 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -5.35235 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -5.22075 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -5.0 |
| LDHD | lactate dehydrogenase D | -4.97675 |
| TLCD3A | TLC domain containing 3A | -4.96105 |
| ISOC1 | isochorismatase domain containing 1 | -4.915 |
| VAT1 | vesicle amine transport 1 | -4.8738 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.84395 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -4.4088 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.3743 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.0696 |
| FASTKD5 | FAST kinase domains 5 | -3.92165 |
| SACM1L | SAC1 suppressor of actin mutations 1-like (yeast) | -3.4959 |
| PRPF4 | pre-mRNA processing factor 4 | -3.4498 |
| DCK | deoxycytidine kinase | -3.32465 |
| CCNB1 | cyclin B1 | -3.1973 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -3.1606 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.903 |
| FBXO7 | F-box protein 7 | -2.84625 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -2.84292 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.81275 |
| COG2 | component of oligomeric golgi complex 2 | -2.7715 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -2.74227 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.68365 |
| NLRP4 | NLR family, pyrin domain containing 4 | -2.5013 |
| DIXDC1 | DIX domain containing 1 | -2.4925 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.42933 |
| TMEM165 | transmembrane protein 165 | -2.33955 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -2.30443 |
| PLS1 | plastin 1 | -2.28015 |
| H2AZ1 | H2A.Z variant histone 1 | -2.27017 |
| C1GALT1C1 | C1GALT1-specific chaperone 1 | -2.26375 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.2518 |
| RPL10A | ribosomal protein L10a | -2.2466 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.19035 |
| PEX11B | peroxisomal biogenesis factor 11 beta | -2.18675 |
| TMEM184C | transmembrane protein 184C | -2.18475 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.1771 |
| ACP3 | acid phosphatase 3 | -2.16715 |
| NSFL1C | NSFL1 (p97) cofactor (p47) | -2.1609 |
| MSRA | methionine sulfoxide reductase A | -2.13725 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.1107 |
| TFB1M | transcription factor B1, mitochondrial | -2.10745 |
| CATSPER2 | cation channel, sperm associated 2 | -2.0873 |
| DDRGK1 | DDRGK domain containing 1 | -2.08165 |
| FTSJ3 | FtsJ homolog 3 (E. coli) | -2.07415 |
| TCIM | transcriptional and immune response regulator | -2.06865 |
| MIS18BP1 | MIS18 binding protein 1 | -2.05885 |
| GDF15 | growth differentiation factor 15 | -2.04505 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | -2.03175 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | -2.02988 |
| ADIRF | adipogenesis regulatory factor | -2.02085 |
| SHPK | sedoheptulokinase | -2.01195 |
| POM121 | POM121 transmembrane nucleoporin | -2.0016 |
