CRCGN008_HEPG2_24H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description c.i. acid orange 10 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

113 genes differentially expressed following the CRCGN008_HEPG2_24H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 7.23285
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.23585
UBE2L6 ubiquitin-conjugating enzyme E2L 6 5.1631
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.93505
ZNF589 zinc finger protein 589 4.83137
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.76663
EPHB2 EPH receptor B2 4.71845
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.44095
STK10 serine/threonine kinase 10 4.4386
STIMATE STIM activating enhancer 4.4013
PNKP polynucleotide kinase 3'-phosphatase 4.38315
GRB10 growth factor receptor-bound protein 10 4.36605
CCL2 chemokine (C-C motif) ligand 2 4.3515
SSBP2 single-stranded DNA binding protein 2 4.02497
BIRC2 baculoviral IAP repeat containing 2 3.9792
HLA-DRA major histocompatibility complex, class II, DR alpha 3.63972
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.16383
EVL Enah/Vasp-like 3.03555
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.0277
TIAM1 T-cell lymphoma invasion and metastasis 1 2.99143
SDC2 syndecan 2 2.61632
GPC3 glypican 3 2.5976
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.575
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.5491
USP6NL USP6 N-terminal like 2.5369
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.5202
TBP TATA box binding protein 2.4576
TPH1 tryptophan hydroxylase 1 2.43795
MSTN myostatin 2.3977
SATB1 SATB homeobox 1 2.3802
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.36125
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 2.3538
COL2A1 collagen, type II, alpha 1 2.33195
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2.307
CPB2 carboxypeptidase B2 (plasma) 2.2798
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 2.2778
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.27755
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.26955
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.25455
HAMP hepcidin antimicrobial peptide 2.24905
ADAT1 adenosine deaminase, tRNA-specific 1 2.24235
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.2216
C8B complement component 8, beta polypeptide 2.20285
CDO1 cysteine dioxygenase type 1 2.19785
SKAP1 src kinase associated phosphoprotein 1 2.18135
VASH2 vasohibin 2 2.1772
C8G complement component 8, gamma polypeptide 2.17295
RPL18 ribosomal protein L18 2.1698
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.14685
ZNF22 zinc finger protein 22 2.13972
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 2.1364
SIX3 SIX homeobox 3 2.13535
CFHR2 complement factor H-related 2 2.1253
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.1194
MKRN2 makorin ring finger protein 2 2.104
NEFH neurofilament, heavy polypeptide 2.10348
APOC2 apolipoprotein C-II 2.1033
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.09417
GBP1 guanylate binding protein 1, interferon-inducible 2.08915
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.06868
TLR4 toll-like receptor 4 2.06555
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 2.0535
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.0531
NMU neuromedin U 2.0377
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.02805
UBE2E1 ubiquitin-conjugating enzyme E2E 1 2.0243
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 2.0212
CPQ carboxypeptidase Q 2.006
AQP9 aquaporin 9 2.003

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PCNA proliferating cell nuclear antigen -5.33725
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.2804
ADI1 acireductone dioxygenase 1 -5.02245
TSPAN4 tetraspanin 4 -4.83835
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.82695
RPIA ribose 5-phosphate isomerase A -4.79495
THAP11 THAP domain containing 11 -4.76905
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7162
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.66275
HLA-DMA major histocompatibility complex, class II, DM alpha -4.48465
RNF167 ring finger protein 167 -3.8518
VDAC1 voltage-dependent anion channel 1 -3.8062
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -3.502
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.31182
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.256
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.99695
OXA1L oxidase (cytochrome c) assembly 1-like -2.86
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.83635
WASHC4 WASH complex subunit 4 -2.75125
PGM1 phosphoglucomutase 1 -2.6814
GCN1 GCN1 activator of EIF2AK4 -2.51517
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.49325
TMED2 transmembrane emp24 domain trafficking protein 2 -2.45413
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.43325
MYBBP1A MYB binding protein (P160) 1a -2.4132
NRIP1 nuclear receptor interacting protein 1 -2.39275
CCNB1 cyclin B1 -2.36135
PLAU plasminogen activator, urokinase -2.34275
POM121C POM121 transmembrane nucleoporin C -2.34092
KDM3B lysine (K)-specific demethylase 3B -2.3296
SPRR2B small proline-rich protein 2B -2.29865
ZDHHC13 zinc finger, DHHC-type containing 13 -2.24045
KRT4 keratin 4, type II -2.16935
ICAM3 intercellular adhesion molecule 3 -2.1582
ACLY ATP citrate lyase -2.15155
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -2.1501
FOS FBJ murine osteosarcoma viral oncogene homolog -2.11825
INAVA innate immunity activator -2.1158
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -2.11185
SPRR1A small proline-rich protein 1A -2.11175
TMEM120B transmembrane protein 120B -2.0947
RNF10 ring finger protein 10 -2.08667
RBM28 RNA binding motif protein 28 -2.0177