CRCGN008_HEPG2_24H:G21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description c.i. acid orange 10 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN008_HEPG2_24H:G21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 5.0836
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.03555
CCDC92 coiled-coil domain containing 92 4.9418
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.7342
ARL4C ADP-ribosylation factor-like 4C 4.54663
PPARG peroxisome proliferator-activated receptor gamma 4.3075
GPER1 G protein-coupled estrogen receptor 1 4.02437
CDPF1 cysteine-rich, DPF motif domain containing 1 3.7726
VAV3 vav 3 guanine nucleotide exchange factor 3.57428
STIMATE STIM activating enhancer 3.4396
SNX7 sorting nexin 7 3.3779
LPAR2 lysophosphatidic acid receptor 2 3.06873
PFKL phosphofructokinase, liver 3.04187
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.99813
EDN1 endothelin 1 2.84235
NRBP1 nuclear receptor binding protein 1 2.55505
ZNF589 zinc finger protein 589 2.52868
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.48975
TMEM106C transmembrane protein 106C 2.4874
FLNA filamin A, alpha 2.44288
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.41083
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.17805
EFNB2 ephrin-B2 2.14908
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.14618
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.10855
CEP57 centrosomal protein 57kDa 2.05252
GATD3 glutamine amidotransferase class 1 domain containing 3 2.0134

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -7.84683
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.48535
MRPS2 mitochondrial ribosomal protein S2 -5.47785
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.3902
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.25325
PCNA proliferating cell nuclear antigen -5.0
TLCD3A TLC domain containing 3A -4.94075
TRIB3 tribbles pseudokinase 3 -4.8087
LOC124907782 dual specificity protein phosphatase 22 -4.62965
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.6121
GOLT1B golgi transport 1B -4.6073
HLA-DMA major histocompatibility complex, class II, DM alpha -4.1155
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.93915
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.5611
GNAS GNAS complex locus -3.46612
RGS2 regulator of G-protein signaling 2 -3.39265
DERA deoxyribose-phosphate aldolase (putative) -3.37115
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -3.20555
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.9017
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.84417
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.77235
CCNB2 cyclin B2 -2.7276
PAEP progestagen-associated endometrial protein -2.7199
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.68828
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.65515
PGM1 phosphoglucomutase 1 -2.56575
OXA1L oxidase (cytochrome c) assembly 1-like -2.51015
COQ4 coenzyme Q4 -2.50705
CCDC91 coiled-coil domain containing 91 -2.2822
TXNDC9 thioredoxin domain containing 9 -2.22143
TSKU tsukushi, small leucine rich proteoglycan -2.1703
KRT10 keratin 10, type I -2.12697
KCNK7 potassium channel, two pore domain subfamily K, member 7 -2.01965
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -2.0095