CRCGN008_HEPG2_24H:G22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description c.i. acid orange 10 5.02 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN008_HEPG2_24H:G22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.8725
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.6694
RPP38 ribonuclease P/MRP 38kDa subunit 5.5955
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.895
PHKA1 phosphorylase kinase, alpha 1 (muscle) 4.70555
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.5572
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.31773
STIMATE STIM activating enhancer 4.21235
SNAP25 synaptosomal-associated protein, 25kDa 4.05263
MINDY1 MINDY lysine 48 deubiquitinase 1 4.02235
LOC122526780 uncharacterized LOC122526780 4.00825
TESK1 testis-specific kinase 1 3.9502
SSBP2 single-stranded DNA binding protein 2 3.949
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.90755
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.88273
GADD45A growth arrest and DNA-damage-inducible, alpha 3.7193
TIAM1 T-cell lymphoma invasion and metastasis 1 3.5967
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.51235
CYCS cytochrome c, somatic 3.448
GLI2 GLI family zinc finger 2 3.3649
MAP7 microtubule-associated protein 7 3.13457
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.85613
ZNF589 zinc finger protein 589 2.79735
TXNL4B thioredoxin-like 4B 2.7628
TRIM13 tripartite motif containing 13 2.7502
EPHA3 EPH receptor A3 2.72763
PTK2 protein tyrosine kinase 2 2.63875
KIF20A kinesin family member 20A 2.58625
SFTPB surfactant protein B 2.41353
PRDX4 peroxiredoxin 4 2.3602
HESX1 HESX homeobox 1 2.32725
PHACTR2 phosphatase and actin regulator 2 2.29637
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.2599
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.25175
IPCEF1 interaction protein for cytohesin exchange factors 1 2.2459
CDCA4 cell division cycle associated 4 2.19255
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 2.1892
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 2.1751
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 2.16453
PHEX phosphate regulating endopeptidase homolog, X-linked 2.1462
KAT2B K(lysine) acetyltransferase 2B 2.14445
SYNC syncoilin, intermediate filament protein 2.14065
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.0984
NLGN1 neuroligin 1 2.0937
FICD FIC domain containing 2.0923
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.0798
PNRC2 proline-rich nuclear receptor coactivator 2 2.06595
FRRS1L ferric-chelate reductase 1-like 2.0541
UIMC1 ubiquitin interaction motif containing 1 2.0439
PGBD5 piggyBac transposable element derived 5 2.04117
HEBP1 heme binding protein 1 2.0343
UBXN2B UBX domain protein 2B 2.02425
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.0149

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -7.9048
OXA1L oxidase (cytochrome c) assembly 1-like -6.0965
PCNA proliferating cell nuclear antigen -5.8868
NGRN neugrin, neurite outgrowth associated -5.33725
SLC35F2 solute carrier family 35, member F2 -5.3217
FASTKD5 FAST kinase domains 5 -5.28055
UGDH UDP-glucose 6-dehydrogenase -5.1956
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.0844
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.43295
HEATR1 HEAT repeat containing 1 -3.80643
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.67975
PRPF4 pre-mRNA processing factor 4 -3.51227
GLOD4 glyoxalase domain containing 4 -3.24815
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.01325
DDIT4 DNA-damage-inducible transcript 4 -2.98045
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.9516
GDF15 growth differentiation factor 15 -2.86185
TENT2 terminal nucleotidyltransferase 2 -2.71675
RNF167 ring finger protein 167 -2.6962
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.52035
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor -2.21935
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.20188
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.167
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.1287
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -2.06635
SNIP1 Smad nuclear interacting protein 1 -2.05965
THOP1 thimet oligopeptidase 1 -2.02795