CRCGN008_HEPG2_24H:H06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-rosaniline.hcl 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

92 genes differentially expressed following the CRCGN008_HEPG2_24H:H06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 5.43935
RPL39L ribosomal protein L39-like 5.4212
CNPY3 canopy FGF signaling regulator 3 5.2891
E2F2 E2F transcription factor 2 5.2216
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.0631
CCNF cyclin F 4.98825
STK10 serine/threonine kinase 10 4.96033
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.79695
PNKP polynucleotide kinase 3'-phosphatase 4.7834
AMDHD2 amidohydrolase domain containing 2 4.66275
DDIT4 DNA-damage-inducible transcript 4 4.5455
MAMLD1 mastermind-like domain containing 1 4.53865
HOXA10 homeobox A10 4.5153
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.47585
INPP1 inositol polyphosphate-1-phosphatase 4.4514
NOTCH1 notch 1 4.44125
ARL4C ADP-ribosylation factor-like 4C 4.18123
BACE2 beta-site APP-cleaving enzyme 2 4.1498
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.81922
PEX11A peroxisomal biogenesis factor 11 alpha 3.64158
HLA-DRA major histocompatibility complex, class II, DR alpha 3.55988
LOC122526780 uncharacterized LOC122526780 3.29915
TIAM1 T-cell lymphoma invasion and metastasis 1 3.2526
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.16925
JADE2 jade family PHD finger 2 3.06997
CBR3 carbonyl reductase 3 3.0436
CCP110 centriolar coiled coil protein 110kDa 2.9436
CDPF1 cysteine-rich, DPF motif domain containing 1 2.93835
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.91385
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.86495
PMM2 phosphomannomutase 2 2.8485
GPATCH8 G patch domain containing 8 2.80132
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.7699
TNIP1 TNFAIP3 interacting protein 1 2.7169
MAST2 microtubule associated serine/threonine kinase 2 2.70975
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.6668
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.62473
STXBP1 syntaxin binding protein 1 2.50355
VAT1 vesicle amine transport 1 2.4536
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.4497
DUSP6 dual specificity phosphatase 6 2.36483
FEV FEV (ETS oncogene family) 2.2862
ACOT9 acyl-CoA thioesterase 9 2.27565
ARHGAP10 Rho GTPase activating protein 10 2.19735
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.18845
CDK19 cyclin-dependent kinase 19 2.16055
LBHD1 LBH domain containing 1 2.0619
PZP pregnancy-zone protein 2.05535
EPHA3 EPH receptor A3 2.0446
DSG2 desmoglein 2 2.04375
STBD1 starch binding domain 1 2.031
PHGDH phosphoglycerate dehydrogenase 2.0074

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.4414
LDHD lactate dehydrogenase D -4.91915
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.72195
ZMIZ1 zinc finger, MIZ-type containing 1 -4.53425
DNM1L dynamin 1-like -4.51775
DERA deoxyribose-phosphate aldolase (putative) -4.4458
CDC25B cell division cycle 25B -4.4442
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.2597
COG7 component of oligomeric golgi complex 7 -3.90645
FASTKD5 FAST kinase domains 5 -3.40555
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.3551
RBM15B RNA binding motif protein 15B -3.2392
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.97795
OXA1L oxidase (cytochrome c) assembly 1-like -2.9496
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.9098
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.8589
PLK1 polo-like kinase 1 -2.7645
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.68467
ACAA1 acetyl-CoA acyltransferase 1 -2.68263
MCM10 minichromosome maintenance complex component 10 -2.5156
SESN1 sestrin 1 -2.4929
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.40015
ZNF586 zinc finger protein 586 -2.3857
RAD51AP1 RAD51 associated protein 1 -2.3237
INTS13 integrator complex subunit 13 -2.3071
GLOD4 glyoxalase domain containing 4 -2.24695
TERT telomerase reverse transcriptase -2.21055
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.20557
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.19143
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.1524
STAT1 signal transducer and activator of transcription 1, 91kDa -2.13013
DYSF dysferlin -2.107
NUP85 nucleoporin 85kDa -2.10585
PIPOX pipecolic acid oxidase -2.0964
PLXNB2 plexin B2 -2.0808
ACO2 aconitase 2, mitochondrial -2.0755
DUSP8 dual specificity phosphatase 8 -2.07075
FHL2 four and a half LIM domains 2 -2.0507
CD58 CD58 molecule -2.01665
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.01215