CRCGN008_HEPG2_24H:H09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tiabendazole 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN008_HEPG2_24H:H09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 10.0
LCN2 lipocalin 2 6.1955
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.038
RPL39L ribosomal protein L39-like 4.63915
GPER1 G protein-coupled estrogen receptor 1 4.36433
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.00723
STXBP2 syntaxin binding protein 2 3.6893
SMIM40 small integral membrane protein 40 3.401
CDCA4 cell division cycle associated 4 3.3193
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.93062
CCNF cyclin F 2.88602
GPATCH8 G patch domain containing 8 2.81492
USP6NL USP6 N-terminal like 2.4881
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.4321
BPHL biphenyl hydrolase-like (serine hydrolase) 2.431
EPHA3 EPH receptor A3 2.3791
LMX1B LIM homeobox transcription factor 1, beta 2.23405
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.2318
RBKS ribokinase 2.2052
SCAND1 SCAN domain containing 1 2.1555
RPL10A ribosomal protein L10a 2.15515
SCRN1 secernin 1 2.1244
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.11845
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 2.1149
MYH13 myosin, heavy chain 13, skeletal muscle 2.09785
LOC122526780 uncharacterized LOC122526780 2.06555
RPL37 ribosomal protein L37 2.0487
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.04615
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.03013
NMU neuromedin U 2.02845
ARID4B AT rich interactive domain 4B (RBP1-like) 2.0209
PYCARD PYD and CARD domain containing 2.0093

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -5.43175
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.18935
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0166
LDHD lactate dehydrogenase D -4.87175
FASTKD5 FAST kinase domains 5 -4.1922
THAP11 THAP domain containing 11 -4.1306
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.2627
OXA1L oxidase (cytochrome c) assembly 1-like -3.09995
SNX11 sorting nexin 11 -2.85895
SESN1 sestrin 1 -2.734
ZNF274 zinc finger protein 274 -2.4598
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.31803
CCL19 chemokine (C-C motif) ligand 19 -2.18265
NRIP1 nuclear receptor interacting protein 1 -2.14115
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.13575
ZNF227 zinc finger protein 227 -2.11285
CCP110 centriolar coiled coil protein 110kDa -2.0867
ZNF226 zinc finger protein 226 -2.04935